SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		3 / 3 VAL A  54
VAL A  83
TRP A  52
 None
 0.62A 1av2A-2x9oA:
undetectable
1av2B-2x9oA:
undetectable		 1av2A-2x9oA:
8.33
1av2B-2x9oA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		3 / 3 ASP A   3
LEU A   6
HIS A 214
 None
 0.77A 1qknA-2x9oA:
undetectable		 1qknA-2x9oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		4 / 7 TYR A 197
TYR A  71
LEU A  80
GLN A 194
 None
 1.14A 1qzrA-2x9oA:
0.1		 1qzrA-2x9oA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		3 / 3 VAL A  54
VAL A  83
TRP A  52
 None
 0.84A 1w5uA-2x9oA:
undetectable
1w5uB-2x9oA:
undetectable		 1w5uA-2x9oA:
8.33
1w5uB-2x9oA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		3 / 3 VAL A  83
TRP A  52
VAL A  54
 None
 0.77A 2izqC-2x9oA:
undetectable
2izqD-2x9oA:
undetectable		 2izqC-2x9oA:
8.33
2izqD-2x9oA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		4 / 4 LEU A  21
PRO A  22
LEU A  43
ARG A  50
 None
 1.25A 3hcoB-2x9oA:
undetectable		 3hcoB-2x9oA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		4 / 4 ASP A 205
SER A 201
PHE A 229
SER A 220
 None
 1.29A 3i5uA-2x9oA:
undetectable		 3i5uA-2x9oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		5 / 12 LEU A  23
PHE A 227
ILE A  39
HIS A  10
VAL A  46
 None
 1.38A 3w1wB-2x9oA:
undetectable		 3w1wB-2x9oA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		3 / 3 ARG A 112
THR A 184
ASP A  77
 None
 0.94A 5g5gA-2x9oA:
0.5
5g5gB-2x9oA:
undetectable		 5g5gA-2x9oA:
19.48
5g5gB-2x9oA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		4 / 6 PHE A 229
ARG A  53
PHE A 211
VAL A  65
 None
None
BLA  A1234 (-4.8A)
BLA  A1234 (-4.5A)
 1.10A 5h4dA-2x9oA:
undetectable		 5h4dA-2x9oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE
(Synechococcus
sp.
WH
8020) 		3 / 3 LEU A 117
SER A 115
PHE A 114
 None
 0.67A 6fgcA-2x9oA:
undetectable		 6fgcA-2x9oA:
20.73