SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		3 / 3 VAL A 307
VAL A  48
TRP A  46
 None
 0.87A 1av2A-2x9pA:
undetectable
1av2B-2x9pA:
undetectable		 1av2A-2x9pA:
3.88
1av2B-2x9pA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		4 / 6 LEU A 151
ILE A 210
ARG A 213
VAL A 160
 None
 1.11A 1db1A-2x9pA:
1.8		 1db1A-2x9pA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		4 / 5 LEU A 198
VAL A 195
LEU A 191
GLN A 188
 None
 0.81A 1fbmE-2x9pA:
undetectable		 1fbmE-2x9pA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		4 / 7 MET A 359
PRO A 148
ALA A 150
ALA A 124
 None
 1.00A 1k5qA-2x9pA:
1.3
1k5qB-2x9pA:
0.6		 1k5qA-2x9pA:
19.19
1k5qB-2x9pA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		5 / 10 GLY A 246
VAL A 247
LEU A 393
LEU A 379
ALA A 251
 None
 0.97A 1pbcA-2x9pA:
undetectable		 1pbcA-2x9pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		3 / 3 LEU A  85
LEU A  82
SER A  79
 None
 0.67A 1tlmA-2x9pA:
undetectable		 1tlmA-2x9pA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		4 / 5 LEU A  57
ASP A  60
VAL A 307
ILE A  63
 None
 0.97A 2aoiB-2x9pA:
undetectable		 2aoiB-2x9pA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		3 / 3 ASP A 244
ASN A 245
THR A 338
 None
None
HEM  A1398 (-4.9A)
 0.71A 2q63B-2x9pA:
undetectable		 2q63B-2x9pA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		5 / 12 LEU A 172
GLY A 174
LEU A 168
ALA A 187
GLY A 230
 None
 1.08A 2vmyA-2x9pA:
undetectable		 2vmyA-2x9pA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		5 / 12 LEU A 214
ASN A 215
GLY A 217
ARG A 103
VAL A 199
 None
 1.46A 3gn8A-2x9pA:
undetectable		 3gn8A-2x9pA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		5 / 12 LEU A 214
ASN A 215
GLY A 217
ARG A 103
VAL A 199
 None
 1.42A 3gn8B-2x9pA:
2.4		 3gn8B-2x9pA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		4 / 8 ILE A 158
ASP A 209
ILE A 211
GLY A 197
 None
 0.78A 4ac9C-2x9pA:
undetectable		 4ac9C-2x9pA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		3 / 3 ARG A 394
ASP A 244
ASP A 237
 None
 0.89A 4kicB-2x9pA:
undetectable		 4kicB-2x9pA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		4 / 8 GLY A 312
LEU A 275
ASN A 315
ARG A 279
 None
 0.96A 4m5mA-2x9pA:
undetectable		 4m5mA-2x9pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		4 / 7 ASP A 244
THR A 146
PHE A 390
HIS A 142
 None
 1.44A 4o4dA-2x9pA:
undetectable		 4o4dA-2x9pA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		4 / 8 ARG A 223
GLY A 230
LEU A 231
LEU A 108
 None
None
HEM  A1398 ( 4.6A)
None
 0.81A 4po0A-2x9pA:
3.8		 4po0A-2x9pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		5 / 12 LEU A 151
PHE A 233
LEU A 191
TYR A 194
GLY A 230
 None
 1.41A 4zbrA-2x9pA:
5.2		 4zbrA-2x9pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		4 / 8 ALA A 278
HIS A 336
ASN A 315
ARG A 279
 None
SO4  A1401 ( 4.7A)
None
None
 1.20A 5db5A-2x9pA:
undetectable
5db5B-2x9pA:
undetectable		 5db5A-2x9pA:
23.58
5db5B-2x9pA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		3 / 3 GLY A 340
LEU A 337
HIS A 341
 HEM  A1398 (-4.1A)
None
None
 0.69A 5u63B-2x9pA:
undetectable		 5u63B-2x9pA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2x9p PIMD PROTEIN
(Streptomyces
natalensis) 		5 / 10 ILE A 133
VAL A 247
ALA A 251
LEU A 363
LEU A 141
 None
 1.03A 6f6nA-2x9pA:
undetectable
6f6nB-2x9pA:
undetectable		 6f6nA-2x9pA:
13.45
6f6nB-2x9pA:
15.87