SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ILE A 535
ASN A 538
PHE A 541
LEU A 478
GLY A 567
 None
 0.90A 1e7aB-2x9xA:
3.4		 1e7aB-2x9xA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ILE A 535
ASN A 538
PHE A 541
LEU A 478
GLY A 567
 None
 0.87A 1e7bA-2x9xA:
undetectable		 1e7bA-2x9xA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 VAL A 426
LEU A 347
PRO A 334
VAL A 381
 None
 1.01A 1fduB-2x9xA:
undetectable		 1fduB-2x9xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 480
THR A 496
VAL A 493
 None
 0.87A 1hxbA-2x9xA:
undetectable		 1hxbA-2x9xA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 VAL A 467
TYR A 477
ARG A 590
THR A 578
 None
 1.32A 1nw3A-2x9xA:
undetectable		 1nw3A-2x9xA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 GLU A 405
ILE A 408
LEU A 347
TRP A 351
 None
 1.10A 1q0yH-2x9xA:
4.7
1q0yL-2x9xA:
3.9		 1q0yH-2x9xA:
17.49
1q0yL-2x9xA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 478
ILE A 565
GLY A 567
ASP A 218
GLY A 217
 None
 1.15A 1zz1C-2x9xA:
undetectable		 1zz1C-2x9xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ASP A 241
TYR A 222
LYS A 443
 None
 1.03A 2othA-2x9xA:
undetectable		 2othA-2x9xA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 480
THR A 496
VAL A 493
 None
 0.56A 2q64A-2x9xA:
undetectable		 2q64A-2x9xA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 480
THR A 496
VAL A 493
 None
 0.75A 2qakA-2x9xA:
undetectable		 2qakA-2x9xA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 TYR A 234
PRO A 434
ASN A 238
ASP A 241
VAL A 320
 None
None
None
None
NA  A1625 (-4.5A)
 1.29A 2zznA-2x9xA:
undetectable		 2zznA-2x9xA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 VAL A 298
LEU A 281
TYR A 234
TYR A 324
PHE A 322
 None
 1.25A 3rc0A-2x9xA:
undetectable		 3rc0A-2x9xA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 242
GLU A 272
THR A 271
 None
 0.93A 3v4tA-2x9xA:
undetectable		 3v4tA-2x9xA:
22.04