SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xa0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		4 / 5 ASP A 171
VAL A 170
SER A 167
ASP A  31
 None
 1.29A 1n2xB-2xa0A:
undetectable		 1n2xB-2xa0A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		4 / 8 ARG A 109
GLY A 155
GLU A 114
ILE A 173
 None
 0.89A 1pk7B-2xa0A:
undetectable		 1pk7B-2xa0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		4 / 8 VAL A 162
VAL A 170
HIS A  20
ASP A 171
 None
 1.01A 2ddwA-2xa0A:
undetectable		 2ddwA-2xa0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		4 / 5 PHE A 151
PHE A 150
PHE A 130
VAL A  15
 None
 1.16A 2lh6A-2xa0A:
undetectable		 2lh6A-2xa0A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		4 / 7 ILE A  19
TYR A  21
ASP A 102
GLU A 152
 None
 1.15A 2qebA-2xa0A:
undetectable		 2qebA-2xa0A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		4 / 7 ILE A  19
TYR A  21
ASP A 102
GLU A 152
 None
 1.14A 2qebB-2xa0A:
undetectable		 2qebB-2xa0A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		3 / 3 LEU A 119
VAL A 162
ARG A 164
 None
 0.83A 3b0wB-2xa0A:
undetectable		 3b0wB-2xa0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		3 / 3 ALA A 174
ARG A  12
LYS A  10
 None
 1.10A 3kp5B-2xa0A:
undetectable		 3kp5B-2xa0A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		4 / 5 PHE A 151
TYR A 180
LEU A  23
LYS A  22
 None
 1.36A 3sugA-2xa0A:
undetectable		 3sugA-2xa0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		3 / 3 ARG A 164
PHE A 130
LEU A 119
 None
 0.90A 5x1bC-2xa0A:
undetectable		 5x1bC-2xa0A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2xa0 APOPTOSIS REGULATOR
BAX
APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A 150
ILE A 147
ASP C  68
GLY C  67
 None
 1.01A 5x5qE-2xa0A:
undetectable		 5x5qE-2xa0A:
21.16