SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xa2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 6 LEU A 169
HIS A  92
LEU A  59
LEU A  62
 None
UPG  A1415 (-4.6A)
None
None
 0.94A 1errA-2xa2A:
undetectable		 1errA-2xa2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 8 ILE A 289
LEU A 267
MET A 322
GLY A 245
 None
 1.03A 1os6A-2xa2A:
undetectable		 1os6A-2xa2A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 6 LEU A 169
TRP A 166
LEU A 158
TRP A 152
 None
 1.31A 1ru9H-2xa2A:
undetectable
1ru9L-2xa2A:
undetectable		 1ru9H-2xa2A:
19.71
1ru9L-2xa2A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 5 LEU A 169
TRP A 166
LEU A 158
TRP A 152
 None
 1.41A 1ruaH-2xa2A:
0.0
1ruaL-2xa2A:
undetectable		 1ruaH-2xa2A:
19.71
1ruaL-2xa2A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 6 LEU A 169
TRP A 166
LEU A 158
TRP A 152
 None
 1.36A 1rukH-2xa2A:
undetectable
1rukL-2xa2A:
undetectable		 1rukH-2xa2A:
19.71
1rukL-2xa2A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 5 LEU A 169
TRP A 166
LEU A 158
TRP A 152
 None
 1.36A 1rulH-2xa2A:
0.0
1rulL-2xa2A:
0.0		 1rulH-2xa2A:
19.71
1rulL-2xa2A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 12 HIS A 155
ILE A 156
LEU A 169
VAL A 114
ILE A  78
 None
UPG  A1415 (-4.3A)
None
None
None
 1.01A 1zq9A-2xa2A:
4.0		 1zq9A-2xa2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 12 ASN A 210
LEU A 206
SER A  61
LEU A  65
THR A 333
 None
 1.19A 2aa5A-2xa2A:
undetectable		 2aa5A-2xa2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 9 GLN A 236
GLU A 334
ILE A 350
ALA A 326
VAL A 347
 None
UPG  A1415 (-3.0A)
None
None
None
 1.28A 2drdA-2xa2A:
undetectable		 2drdA-2xa2A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 6 ILE A  58
SER A  61
ARG A  14
ILE A 399
 None
 1.06A 2q72A-2xa2A:
undetectable		 2q72A-2xa2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 12 ARG A 116
PHE A 172
ILE A  78
TYR A 111
GLY A  80
 None
 1.29A 2vufA-2xa2A:
0.3		 2vufA-2xa2A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2001_1
(SERUM ALBUMIN)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 12 ARG A 116
PHE A 172
ILE A  78
TYR A 111
GLY A  80
 None
 1.36A 2vufB-2xa2A:
0.0		 2vufB-2xa2A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 7 TYR A 111
GLU A 142
TYR A 176
TRP A 150
 None
 1.42A 3cotA-2xa2A:
0.7		 3cotA-2xa2A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		3 / 3 THR A 216
LYS A 391
GLU A 217
 None
 0.80A 3ijdB-2xa2A:
undetectable		 3ijdB-2xa2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 10 PHE A  43
ILE A 410
LEU A 131
HIS A  45
HIS A 133
 None
 1.20A 3o1cA-2xa2A:
undetectable		 3o1cA-2xa2A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 10 PHE A  43
ILE A 410
LEU A 131
HIS A  45
HIS A 133
 None
 1.17A 3o1xA-2xa2A:
undetectable		 3o1xA-2xa2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 11 ILE A 221
SER A 316
ILE A 233
PHE A 225
VAL A 227
 None
 1.25A 3rf4B-2xa2A:
undetectable
3rf4C-2xa2A:
undetectable		 3rf4B-2xa2A:
14.80
3rf4C-2xa2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 9 PHE A 225
ASN A 300
ILE A 302
GLY A 303
PHE A 312
 None
 1.44A 3t3rC-2xa2A:
undetectable		 3t3rC-2xa2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 5 ILE A 180
PHE A 172
HIS A 403
ASP A 134
 None
 1.31A 4rzvB-2xa2A:
undetectable		 4rzvB-2xa2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 5 HIS A 273
TRP A 279
GLY A 269
ASN A 300
 None
None
UPG  A1415 (-2.9A)
None
 1.39A 5x7pB-2xa2A:
3.0		 5x7pB-2xa2A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		3 / 3 PHE A 240
ASP A 241
LYS A 244
 None
None
UPG  A1415 (-3.3A)
 0.88A 6awtD-2xa2A:
undetectable		 6awtD-2xa2A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 12 PRO A 135
LEU A  95
PRO A 189
TRP A 152
LEU A 158
 None
 1.35A 6eliA-2xa2A:
undetectable		 6eliA-2xa2A:
14.01