SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xa7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 5 LEU A 526
LEU A 487
LEU A 447
GLY A 500
 None
 0.89A 1a4lC-2xa7A:
undetectable		 1a4lC-2xa7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		4 / 8 LEU B 396
ALA B 410
ILE B 451
ILE B 399
 None
 0.71A 1d4yB-2xa7B:
undetectable		 1d4yB-2xa7B:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 10 VAL A 483
VAL A 425
VAL A 461
VAL A 465
LEU A 447
 None
 1.01A 1fe2A-2xa7A:
undetectable		 1fe2A-2xa7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA
(Rattus
norvegicus;
Homo
sapiens) 		3 / 3 GLN B 481
TYR A 463
ARG A 464
 None
 0.62A 1gtbA-2xa7B:
2.6		 1gtbA-2xa7B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA
(Rattus
norvegicus;
Homo
sapiens) 		4 / 6 TYR B 524
ILE A 470
GLU A 506
ARG B 528
 None
 1.29A 1oniA-2xa7B:
undetectable
1oniC-2xa7B:
undetectable		 1oniA-2xa7B:
12.28
1oniC-2xa7B:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA
(Rattus
norvegicus;
Homo
sapiens) 		4 / 7 TYR B 524
ILE A 470
GLU A 506
ARG B 528
 None
 1.14A 1oniD-2xa7B:
undetectable
1oniE-2xa7B:
undetectable		 1oniD-2xa7B:
12.28
1oniE-2xa7B:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 LEU B 396
ILE B 417
PHE B 418
ILE B 428
MET B 448
 None
 1.37A 1osvB-2xa7B:
0.0		 1osvB-2xa7B:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 8 GLY A 454
VAL A 457
GLU A 422
ILE A 450
 None
 0.89A 1pk7B-2xa7A:
undetectable		 1pk7B-2xa7A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		3 / 3 LYS A 434
ILE A 468
THR A 445
 None
 0.83A 1rx3A-2xa7A:
undetectable		 1rx3A-2xa7A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		3 / 3 LEU A 616
LEU A 613
SER A 610
 None
 0.64A 1tlmA-2xa7A:
undetectable		 1tlmA-2xa7A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 MET B 110
ASN B  89
GLN B  59
 None
 1.00A 1xoqB-2xa7B:
undetectable		 1xoqB-2xa7B:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 12 PHE A  97
ILE A  72
ASN A  34
LEU A  37
PHE A  44
 None
 0.97A 2bdmA-2xa7A:
undetectable		 2bdmA-2xa7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 LEU B 436
LEU B 465
ILE B 451
ILE B 429
ALA B 430
 None
 1.04A 2bxcA-2xa7B:
undetectable		 2bxcA-2xa7B:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 LEU B 436
LEU B 465
ILE B 451
ILE B 429
ALA B 430
 None
 0.97A 2bxqA-2xa7B:
undetectable		 2bxqA-2xa7B:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 8 GLN A 476
VAL A 483
GLY A 505
GLY A 501
 None
 0.68A 2vinA-2xa7A:
undetectable		 2vinA-2xa7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 VAL B 310
ILE B 306
PHE B 369
GLU B 337
ALA B 376
 None
 1.32A 3apwA-2xa7B:
undetectable		 3apwA-2xa7B:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 9 LEU A 257
VAL A 309
ILE A 287
PRO A 253
ALA A 254
 None
 1.05A 3el0B-2xa7A:
undetectable		 3el0B-2xa7A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 11 LEU A 175
ALA A 169
ILE A 151
SER A 167
LEU A 132
 None
 1.21A 3gyqB-2xa7A:
undetectable		 3gyqB-2xa7A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		4 / 7 VAL B 177
VAL B 181
LEU B 184
SER B 185
 None
 0.86A 3hs6B-2xa7B:
undetectable		 3hs6B-2xa7B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		3 / 3 ARG A 388
GLU A 423
TYR A 412
 None
 0.82A 3k37B-2xa7A:
undetectable		 3k37B-2xa7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 GLU B 544
GLU B 426
ASN B 423
 None
 0.90A 3lp9B-2xa7B:
undetectable
3lp9D-2xa7B:
undetectable		 3lp9B-2xa7B:
17.40
3lp9D-2xa7B:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 8 TYR A 502
PHE A 507
GLN A 476
ASP A 473
 None
 1.12A 3mjrD-2xa7A:
undetectable		 3mjrD-2xa7A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 TYR A 583
LEU B 507
ILE B 525
GLY B 523
LEU B 482
 None
 1.04A 3n8zB-2xa7A:
undetectable		 3n8zB-2xa7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 VAL B 244
LEU B 211
VAL B 255
ALA B 259
LEU B 263
 None
 0.97A 3nt1A-2xa7B:
undetectable		 3nt1A-2xa7B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 VAL B 244
LEU B 211
VAL B 255
ALA B 259
LEU B 263
 None
 0.97A 3nt1B-2xa7B:
undetectable		 3nt1B-2xa7B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 LYS B 318
GLN B 311
ILE B 564
LEU B 267
 None
 1.30A 3qt0A-2xa7B:
0.0		 3qt0A-2xa7B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 12 LEU A 541
LEU A 526
LEU A 525
GLN A 488
VAL A 483
 None
 1.33A 3zqtA-2xa7A:
undetectable		 3zqtA-2xa7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 12 ALA A  79
ASN A  81
ILE A 112
LEU A 101
ILE A 109
 None
 0.96A 4aztA-2xa7A:
undetectable		 4aztA-2xa7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 12 ALA A  79
ASN A  81
ILE A 112
LEU A 101
ILE A 109
 None
 0.95A 4azvA-2xa7A:
undetectable		 4azvA-2xa7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 LEU B 465
GLU B 464
SER B 468
 None
 0.76A 4ccqA-2xa7B:
undetectable		 4ccqA-2xa7B:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 8 GLN A 333
ASN A 307
ASN A 289
THR A 286
 None
 1.45A 4d1yA-2xa7A:
undetectable
4d1yB-2xa7A:
undetectable		 4d1yA-2xa7A:
13.94
4d1yB-2xa7A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 8 PHE A 548
GLY A 505
LEU A 504
ILE A 503
 None
 0.86A 4em2A-2xa7A:
undetectable		 4em2A-2xa7A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		3 / 3 LYS A 434
ILE A 468
THR A 445
 None
 0.87A 4gh8A-2xa7A:
undetectable		 4gh8A-2xa7A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 7 VAL A 390
GLN A 387
MET A 409
LEU A 413
 None
 1.07A 4hxyB-2xa7A:
undetectable		 4hxyB-2xa7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 7 VAL A 390
ILE A 424
ILE A 420
ALA A 416
 None
 0.87A 4lv9A-2xa7A:
undetectable		 4lv9A-2xa7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 7 VAL A 390
ILE A 424
ILE A 420
ALA A 416
 None
 0.86A 4lv9B-2xa7A:
undetectable		 4lv9B-2xa7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 12 LEU A 526
GLY A 508
PHE A 523
ASP A 514
ALA A 480
 None
 1.22A 4pclA-2xa7A:
undetectable		 4pclA-2xa7A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		4 / 8 LEU B 130
VAL B 176
VAL B 137
LEU B 165
 None
 1.16A 4q0bA-2xa7B:
undetectable		 4q0bA-2xa7B:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 8 ILE A 470
VAL A 461
ILE A 612
PHE A 605
 None
 0.79A 4r38A-2xa7A:
undetectable		 4r38A-2xa7A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		5 / 9 LEU B 257
GLY B 568
ILE B 306
LEU B 303
VAL B 301
 None
 1.06A 4x3mB-2xa7B:
undetectable		 4x3mB-2xa7B:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 9 LEU A 334
GLY A 335
LEU A 338
LEU A 350
ALA A 349
 None
 0.93A 5dqfA-2xa7A:
undetectable		 5dqfA-2xa7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 ASP B 158
LEU B 197
ARG B 166
 None
 0.78A 5e8qA-2xa7B:
undetectable		 5e8qA-2xa7B:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA
(Rattus
norvegicus;
Homo
sapiens) 		5 / 8 ALA B 487
THR B 486
VAL B 489
TYR B 526
GLU A 575
 None
 1.49A 5ecnD-2xa7B:
undetectable		 5ecnD-2xa7B:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		4 / 9 ILE A 452
ASN A 495
ASP A 455
ILE A 450
 None
 0.90A 5lg3I-2xa7A:
1.1		 5lg3I-2xa7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 12 ILE A  72
ILE A  40
VAL A  59
LEU A  63
LEU A 101
 None
 1.06A 6ajiA-2xa7A:
undetectable		 6ajiA-2xa7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA
(Rattus
norvegicus;
Homo
sapiens) 		5 / 12 ILE B 548
GLN A 577
VAL B 541
GLU A 575
VAL A 535
 None
 1.30A 6bzoC-2xa7B:
undetectable		 6bzoC-2xa7B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
(Rattus
norvegicus) 		5 / 9 ASN A 509
ILE A 503
ILE A 470
VAL A 499
ILE A 466
 None
 1.43A 6hloA-2xa7A:
undetectable		 6hloA-2xa7A:
21.19