SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xa8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 7 TYR H  33
THR H  53
TYR H  54
ASN H  59
 None
 0.79A 2g70A-2xa8H:
undetectable		 2g70A-2xa8H:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 SER H 136
LEU H 132
ALA H 145
SER H 135
 None
 0.95A 4ikjA-2xa8H:
undetectable
4ikjB-2xa8H:
undetectable		 4ikjA-2xa8H:
20.63
4ikjB-2xa8H:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 LEU H 132
ALA H 145
SER H 135
SER H 136
 None
 0.89A 4ikkA-2xa8H:
undetectable
4ikkB-2xa8H:
undetectable		 4ikkA-2xa8H:
20.63
4ikkB-2xa8H:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 1.02A 5bxnH-2xa8H:
undetectable
5bxnI-2xa8H:
undetectable		 5bxnH-2xa8H:
23.05
5bxnI-2xa8H:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 THR H  53
SER H  34
TYR H  33
 None
 0.87A 5jsdA-2xa8H:
2.3		 5jsdA-2xa8H:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 THR H  53
SER H  34
TYR H  33
 None
 0.88A 5jsdB-2xa8H:
undetectable		 5jsdB-2xa8H:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 THR H  53
SER H  34
TYR H  33
 None
 0.88A 5jsdC-2xa8H:
2.6		 5jsdC-2xa8H:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 THR H  53
SER H  34
TYR H  33
 None
 0.88A 5jseA-2xa8H:
2.3		 5jseA-2xa8H:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 THR H  53
SER H  34
TYR H  33
 None
 0.86A 5jseB-2xa8H:
undetectable		 5jseB-2xa8H:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 THR H  53
SER H  34
TYR H  33
 None
 0.87A 5jseC-2xa8H:
2.6		 5jseC-2xa8H:
16.39