SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 4 ILE A 307
LEU A 304
VAL A 300
ALA A 294
 None
 0.83A 1mz9A-2xalA:
undetectable		 1mz9A-2xalA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 307
LEU A 304
VAL A 300
ALA A 294
 None
 0.83A 1mz9C-2xalA:
undetectable		 1mz9C-2xalA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 301
LEU A 304
PHE A 218
TYR A 212
 None
 0.99A 2vq5B-2xalA:
undetectable		 2vq5B-2xalA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		5 / 12 GLN A  42
LEU A 410
GLN A  66
LEU A  84
ARG A  87
 None
 1.16A 3fsuA-2xalA:
undetectable		 3fsuA-2xalA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 282
SER A 278
THR A 395
GLU A 279
 None
 1.36A 3tm4B-2xalA:
undetectable		 3tm4B-2xalA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		5 / 12 THR A 235
ASP A 216
VAL A 295
ASN A 239
PRO A 169
 None
 1.18A 3v8vA-2xalA:
undetectable		 3v8vA-2xalA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		5 / 8 VAL A  24
VAL A  38
MET A 372
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 (-3.5A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.67A 3warA-2xalA:
4.8		 3warA-2xalA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 315
ILE A 356
TYR A 360
GLU A 359
 None
 1.08A 4a99D-2xalA:
undetectable		 4a99D-2xalA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 5 LEU A 144
ARG A  40
ILE A  93
ASN A  72
 None
ADP  A 600 (-3.7A)
None
None
 1.46A 4i00A-2xalA:
undetectable		 4i00A-2xalA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA501_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 5 LEU A 422
LYS A 425
ASP A 423
HIS A 196
 None
None
None
I6P  A 500 (-4.3A)
 1.43A 4i90A-2xalA:
0.0		 4i90A-2xalA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 8 PRO A 169
LEU A 304
VAL A 102
VAL A 403
 None
 0.90A 4pwdA-2xalA:
undetectable		 4pwdA-2xalA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 8 ASP A 311
ILE A 180
ASP A 423
TYR A 420
 None
 0.84A 4xjeA-2xalA:
undetectable		 4xjeA-2xalA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 6 CYH A 369
LEU A 408
HIS A 101
LEU A  97
 None
 0.90A 5hpuC-2xalA:
undetectable
5hpuD-2xalA:
undetectable		 5hpuC-2xalA:
4.15
5hpuD-2xalA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 167
LEU A 408
HIS A 101
VAL A 300
 None
 1.16A 5jmnB-2xalA:
undetectable		 5jmnB-2xalA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		5 / 8 VAL A  24
VAL A  38
MET A 372
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 (-3.5A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.58A 5y9mA-2xalA:
2.9		 5y9mA-2xalA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		5 / 8 VAL A  24
VAL A  38
MET A 372
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 (-3.5A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.61A 5y9mX-2xalA:
3.8		 5y9mX-2xalA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		5 / 7 VAL A  24
VAL A  38
MET A 372
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 (-3.5A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.76A 5yf9B-2xalA:
2.8		 5yf9B-2xalA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		5 / 9 VAL A  24
VAL A  38
MET A 372
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 (-3.5A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.77A 5yf9X-2xalA:
3.8		 5yf9X-2xalA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		4 / 7 VAL A  24
VAL A  38
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.47A 5ywmX-2xalA:
4.3		 5ywmX-2xalA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Arabidopsis
thaliana) 		3 / 3 ARG A 283
ILE A 276
SER A 278
 None
 0.83A 5zw2A-2xalA:
undetectable		 5zw2A-2xalA:
23.58