SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xb6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 11 LEU C 126
VAL C 127
SER C 118
ILE C 115
ALA C 272
 None
 1.18A 2zbzA-2xb6C:
undetectable		 2zbzA-2xb6C:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 ILE C 168
ASP C 190
SER C 259
ILE C 115
LEU C 141
 None
EDO  C1292 (-3.8A)
None
None
None
 1.05A 4dfrA-2xb6C:
undetectable		 4dfrA-2xb6C:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 GLY C 116
ILE C 245
VAL C 150
VAL C 268
ILE C 243
 EDO  C1295 ( 4.6A)
None
None
None
None
 1.01A 4q5mA-2xb6C:
undetectable		 4q5mA-2xb6C:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 ILE C 168
ASP C 190
SER C 259
ILE C 115
LEU C 141
 None
EDO  C1292 (-3.8A)
None
None
None
 1.04A 4qi9A-2xb6C:
undetectable		 4qi9A-2xb6C:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 ILE C 168
ASP C 190
SER C 259
ILE C 115
LEU C 141
 None
EDO  C1292 (-3.8A)
None
None
None
 0.93A 5hi6B-2xb6C:
undetectable		 5hi6B-2xb6C:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		6 / 12 GLY C  93
PHE C  89
VAL C 282
ILE C  96
THR C  97
GLY C 247
 None
 1.27A 5hieA-2xb6C:
undetectable		 5hieA-2xb6C:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		6 / 12 GLY C  93
PHE C  89
VAL C 282
ILE C  96
THR C  97
GLY C 247
 None
 1.27A 5hieB-2xb6C:
undetectable		 5hieB-2xb6C:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		6 / 12 GLY C  93
PHE C  89
VAL C 282
ILE C  96
THR C  97
GLY C 247
 None
 1.26A 5hieD-2xb6C:
undetectable		 5hieD-2xb6C:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		4 / 7 ILE C 168
HIS C 142
LEU C 126
ALA C 124
 None
 0.89A 5hrqE-2xb6C:
undetectable
5hrqF-2xb6C:
undetectable
5hrqJ-2xb6C:
undetectable		 5hrqE-2xb6C:
7.69
5hrqF-2xb6C:
12.00
5hrqJ-2xb6C:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		4 / 6 PHE C 237
ARG C 180
ASN C 264
ASP C 111
 None
None
EDO  C1293 ( 4.5A)
None
 1.28A 6dhbA-2xb6C:
undetectable		 6dhbA-2xb6C:
21.74