SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A51_A_VDYA6178_1 (VITAMIN D HYDROXYLASE)	2xbt	CELLULOSOMAL SCAFFOLDIN (Pseudobacteroide s cellulosolvens)	5 / 11	ILE A 113 LEU A 93 ILE A 45 VAL A 146 LEU A 12	None	0.93A	3a51A-2xbtA: undetectable	3a51A-2xbtA: 16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A51_D_VDYD6178_1 (VITAMIN D HYDROXYLASE)	2xbt	CELLULOSOMAL SCAFFOLDIN (Pseudobacteroide s cellulosolvens)	5 / 12	ILE A 113 LEU A 93 ILE A 45 VAL A 146 LEU A 12	None	0.95A	3a51D-2xbtA: undetectable	3a51D-2xbtA: 16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4COX_C_IMNC701_1 (CYCLOOXYGENASE-2)	2xbt	CELLULOSOMAL SCAFFOLDIN (Pseudobacteroide s cellulosolvens)	5 / 12	LEU A 145 SER A 132 TYR A 49 GLY A 141 LEU A 12	None	1.12A	4coxC-2xbtA: undetectable	4coxC-2xbtA: 14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GRQ_C_AVLC203_1 (MACROPHAGE MIGRATION INHIBITORY FACTOR)	2xbt	CELLULOSOMAL SCAFFOLDIN (Pseudobacteroide s cellulosolvens)	4 / 7	TYR A 49 PRO A 134 TYR A 133 PHE A 14	None	1.20A	4grqA-2xbtA: undetectable 4grqC-2xbtA: undetectable	4grqA-2xbtA: 23.08 4grqC-2xbtA: 23.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3A51_A_VDYA6178_1","VITAMIN D HYDROXYLASE","2xbt","CELLULOSOMAL SCAFFOLDIN","Pseudobacteroides cellulosolvens",5,"ILE A 113;LEU A  93;ILE A  45;VAL A 146;LEU A  12","None","0.93A","3a51A-2xbtA:undetectable","3a51A-2xbtA:16.50"],["3A51_D_VDYD6178_1","VITAMIN D HYDROXYLASE","2xbt","CELLULOSOMAL SCAFFOLDIN","Pseudobacteroides cellulosolvens",5,"ILE A 113;LEU A  93;ILE A  45;VAL A 146;LEU A  12","None","0.95A","3a51D-2xbtA:undetectable","3a51D-2xbtA:16.50"],["4COX_C_IMNC701_1","CYCLOOXYGENASE-2","2xbt","CELLULOSOMAL SCAFFOLDIN","Pseudobacteroides cellulosolvens",5,"LEU A 145;SER A 132;TYR A  49;GLY A 141;LEU A  12","None","1.12A","4coxC-2xbtA:undetectable","4coxC-2xbtA:14.18"],["4GRQ_C_AVLC203_1","MACROPHAGE MIGRATION INHIBITORY FACTOR;MACROPHAGE MIGRATION INHIBITORY FACTOR","2xbt","CELLULOSOMAL SCAFFOLDIN","Pseudobacteroides cellulosolvens",4,"TYR A  49;PRO A 134;TYR A 133;PHE A  14","None","1.20A","4grqA-2xbtA:undetectable;4grqC-2xbtA:undetectable","4grqA-2xbtA:23.08;4grqC-2xbtA:23.08"]]