SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 12 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ADP  A1211 ( 2.6A)
ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
 0.36A 1s14A-2xcmA:
10.1		 1s14A-2xcmA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		6 / 12 SER A  40
ASP A  42
ASP A  81
MET A  86
ASP A 144
THR A 173
 ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
None
ADP  A1211 (-3.4A)
 1.26A 1s14A-2xcmA:
10.1		 1s14A-2xcmA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 12 SER A  40
ASP A  42
ASP A  81
MET A  86
ASP A 144
 ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
None
 1.39A 1s14B-2xcmA:
10.8		 1s14B-2xcmA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 12 THR A 139
ALA A 129
PHE A 126
ILE A  79
LEU A 187
 None
 1.06A 2nyrA-2xcmA:
undetectable		 2nyrA-2xcmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		4 / 6 LEU A 131
TYR A  26
ILE A 119
ILE A  21
 None
 0.88A 2q8hA-2xcmA:
5.3		 2q8hA-2xcmA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		4 / 4 LEU A  91
GLN A 147
THR A 140
THR A 159
 None
 1.47A 2zj0D-2xcmA:
undetectable		 2zj0D-2xcmA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		4 / 8 GLY A 172
ASN A 143
ILE A  47
ALA A  43
 None
None
None
ADP  A1211 (-3.2A)
 0.97A 3aodA-2xcmA:
undetectable		 3aodA-2xcmA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 12 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ADP  A1211 ( 2.6A)
ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
 0.32A 3lpsA-2xcmA:
11.9		 3lpsA-2xcmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 12 SER A  40
ASP A  42
ASP A  81
ASP A 144
THR A 173
 ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
None
ADP  A1211 (-3.4A)
 1.19A 3lpsA-2xcmA:
11.9		 3lpsA-2xcmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 12 SER A  40
ASP A  42
ASP A  81
MET A  86
THR A 173
 ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
ADP  A1211 (-3.4A)
 0.69A 3lpsA-2xcmA:
11.9		 3lpsA-2xcmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
RAR1
(Hordeum
vulgare;
Arabidopsis
thaliana) 		4 / 6 GLU E 206
ARG E 192
ASP A  45
ARG A  48
 None
 1.31A 4kcnB-2xcmE:
undetectable		 4kcnB-2xcmE:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 11 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ADP  A1211 ( 2.6A)
ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
 0.34A 4urnA-2xcmA:
11.9		 4urnA-2xcmA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 11 SER A  40
ASP A  42
ASP A  81
MET A  86
THR A 173
 ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
ADP  A1211 (-3.4A)
 0.69A 4urnA-2xcmA:
11.9		 4urnA-2xcmA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 11 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ADP  A1211 ( 2.6A)
ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
 0.42A 4urnB-2xcmA:
11.3		 4urnB-2xcmA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 11 SER A  40
ASP A  42
ASP A  81
MET A  86
THR A 173
 ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
ADP  A1211 (-3.4A)
 0.72A 4urnB-2xcmA:
11.3		 4urnB-2xcmA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 11 ASN A  39
SER A  40
ASP A  42
ASP A  81
THR A 173
 ADP  A1211 ( 2.6A)
ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
 0.39A 4urnC-2xcmA:
11.7		 4urnC-2xcmA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 11 SER A  40
ASP A  42
ASP A  81
MET A  86
THR A 173
 ADP  A1211 ( 4.0A)
None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.4A)
ADP  A1211 (-3.4A)
 0.69A 4urnC-2xcmA:
11.7		 4urnC-2xcmA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 12 ILE A 119
LEU A 110
PHE A 106
GLY A 123
GLY A 120
 None
None
None
ADP  A1211 (-2.9A)
MG  A1212 ( 4.9A)
 1.18A 5l6eA-2xcmA:
undetectable		 5l6eA-2xcmA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		5 / 12 GLY A 102
SER A 101
LYS A 104
ASN A  15
GLN A  11
 None
 0.93A 5nwuA-2xcmA:
undetectable		 5nwuA-2xcmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90
(Hordeum
vulgare) 		4 / 5 GLY A 172
THR A 173
SER A  41
SER A  40
 None
ADP  A1211 (-3.4A)
None
ADP  A1211 ( 4.0A)
 1.12A 6jmjA-2xcmA:
undetectable		 6jmjA-2xcmA:
21.60