SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xd3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		5 / 7 ALA A 252
ASP A 192
GLY A 253
GLY A 251
PHE A 392
 GLC  A1423 (-4.6A)
GLC  A1423 (-3.2A)
GLC  A1423 (-3.3A)
GLC  A1423 (-3.4A)
None
 1.31A 2c49B-2xd3A:
undetectable		 2c49B-2xd3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A 144
GLY A 305
GLY A  80
LEU A  81
LEU A  84
 None
 1.05A 2hw2A-2xd3A:
undetectable		 2hw2A-2xd3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TYR A 152
GLU A 147
ASP A 102
 None
GLC  A1418 (-2.9A)
GLC  A1419 (-2.8A)
 0.81A 3bxoA-2xd3A:
undetectable		 3bxoA-2xd3A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TYR A 152
GLU A 147
ASP A 102
 None
GLC  A1418 (-2.9A)
GLC  A1419 (-2.8A)
 0.80A 3bxoB-2xd3A:
undetectable		 3bxoB-2xd3A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ILE A 269
PHE A 196
PHE A 302
GLY A 271
 None
 1.08A 3em0B-2xd3A:
undetectable		 3em0B-2xd3A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 202
GLY A 207
ALA A 208
SER A 228
LEU A 223
 None
 1.20A 3n8xA-2xd3A:
undetectable		 3n8xA-2xd3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ILE A 256
TRP A 242
TRP A 238
THR A 292
 None
 1.28A 3topA-2xd3A:
undetectable		 3topA-2xd3A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 PRO A 291
ILE A 256
TRP A 242
TRP A 238
 None
 1.31A 3topB-2xd3A:
undetectable		 3topB-2xd3A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 TYR A 285
VAL A 287
PHE A 278
ILE A 268
 None
 0.85A 3zjqB-2xd3A:
undetectable		 3zjqB-2xd3A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ASN A 406
ASP A 220
GLY A 222
SER A 228
ASN A 225
 None
 1.26A 4djfA-2xd3A:
undetectable		 4djfA-2xd3A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ILE A 221
LYS A 219
ILE A 412
ALA A 382
 None
 0.95A 4ou1A-2xd3A:
undetectable		 4ou1A-2xd3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_1
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ASP A  82
ASP A 102
ASN A 195
TRP A 273
LYS A 306
 GLC  A1421 (-2.8A)
GLC  A1419 (-2.8A)
GLC  A1419 (-2.9A)
GLC  A1418 (-3.7A)
GLC  A1417 (-2.6A)
 0.68A 4uacA-2xd3A:
36.6		 4uacA-2xd3A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 LEU A 391
ALA A 405
VAL A 383
ILE A 412
 None
 0.99A 4xe3A-2xd3A:
undetectable		 4xe3A-2xd3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 TYR A 352
ASP A 338
ILE A 343
ASP A 358
 None
 0.90A 4xjeA-2xd3A:
undetectable		 4xjeA-2xd3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ALA A 172
TYR A 177
PRO A 162
 None
 0.72A 4zdyA-2xd3A:
undetectable		 4zdyA-2xd3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A 368
ILE A 146
GLY A 304
THR A 127
 None
 1.02A 4zxiA-2xd3A:
undetectable		 4zxiA-2xd3A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A 368
ILE A 146
GLY A 305
THR A 127
 None
 1.14A 4zxiA-2xd3A:
undetectable		 4zxiA-2xd3A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 TYR A 352
ASP A 338
ILE A 343
ASP A 358
 None
 0.88A 5cfsA-2xd3A:
undetectable		 5cfsA-2xd3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLU A 342
TYR A  51
TRP A 308
PRO A  94
GLY A 303
 GLC  A1417 ( 4.7A)
GLC  A1417 (-4.9A)
None
None
None
 1.20A 6gngA-2xd3A:
undetectable		 6gngA-2xd3A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 GLY A 227
ALA A 405
LEU A 223
GLY A 222
LEU A  78
 None
None
None
None
GLC  A1421 (-3.9A)
 1.44A 6hqbA-2xd3A:
undetectable
6hqbJ-2xd3A:
undetectable		 6hqbA-2xd3A:
10.86
6hqbJ-2xd3A:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 GLY A 286
TYR A 152
ASN A 341
GLU A 342
 None
None
None
GLC  A1417 ( 4.7A)
 0.81A 6n7fA-2xd3A:
undetectable		 6n7fA-2xd3A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 GLY A 286
TYR A 152
ASN A 341
GLY A 271
 None
 0.95A 6n7fA-2xd3A:
undetectable		 6n7fA-2xd3A:
11.74