SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 8 GLY A 343
GLY A 375
SER A 333
GLY A 362
 None
 0.75A 1d0vA-2xd4A:
undetectable		 1d0vA-2xd4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 8 GLY A 343
GLY A 375
SER A 333
GLY A 362
 None
 0.77A 1jhaA-2xd4A:
undetectable		 1jhaA-2xd4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 8 GLY A 343
GLY A 375
SER A 333
GLY A 362
 None
 0.70A 1jhqA-2xd4A:
undetectable		 1jhqA-2xd4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 8 GLY A 343
GLY A 375
SER A 333
GLY A 362
 None
 0.70A 1jhvA-2xd4A:
undetectable		 1jhvA-2xd4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 7 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.73A 1pthA-2xd4A:
undetectable		 1pthA-2xd4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 7 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.73A 1pthB-2xd4A:
undetectable		 1pthB-2xd4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 7 THR A 353
ALA A 351
LEU A 349
SER A 348
 None
 0.96A 1tyrB-2xd4A:
undetectable		 1tyrB-2xd4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 11 GLU A 292
MET A 207
VAL A 250
GLY A 289
VAL A 199
 None
 1.16A 2uxpB-2xd4A:
undetectable		 2uxpB-2xd4A:
18.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		7 / 8 ASP A 212
TYR A 269
ASN A 285
ARG A 287
GLY A 289
PRO A 291
GLU A 292
 None
None
MG  A 451 (-2.8A)
MG  A 451 ( 4.9A)
None
None
None
 0.68A 2ys6A-2xd4A:
55.2		 2ys6A-2xd4A:
58.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 8 LYS A 214
ASN A 285
ARG A 287
GLY A 289
PRO A 291
 MG  A 453 ( 3.5A)
MG  A 451 (-2.8A)
MG  A 451 ( 4.9A)
None
None
 0.97A 2ys6A-2xd4A:
55.2		 2ys6A-2xd4A:
58.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 8 LEU A 272
SER A 279
PHE A 193
THR A 241
 None
 0.99A 3ax9A-2xd4A:
2.2		 3ax9A-2xd4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 10 PRO A  73
LEU A  54
ILE A   6
PRO A  70
GLY A   7
 None
 1.24A 3ijxB-2xd4A:
undetectable
3ijxD-2xd4A:
undetectable		 3ijxB-2xd4A:
20.38
3ijxD-2xd4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 6 TYR A 231
PHE A 387
PRO A 235
LEU A 417
 None
 1.44A 3tgvB-2xd4A:
undetectable		 3tgvB-2xd4A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 12 ALA A 164
LEU A 166
ILE A 140
ALA A 156
ILE A 184
 None
 0.93A 4o2bD-2xd4A:
undetectable		 4o2bD-2xd4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 12 VAL A 356
HIS A  13
ALA A 351
LEU A 349
PHE A 370
 None
 1.43A 4qdcA-2xd4A:
0.0		 4qdcA-2xd4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 12 ASP A 399
VAL A 398
VAL A 380
LEU A 331
ALA A 332
 None
 1.32A 4yhaA-2xd4A:
undetectable		 4yhaA-2xd4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 12 VAL A 358
ASP A  35
HIS A 360
ALA A 378
THR A 344
 None
 1.40A 5hnzB-2xd4A:
undetectable		 5hnzB-2xd4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 10 VAL A 267
ALA A 197
THR A 248
GLY A 271
LEU A 272
 None
 1.25A 5m5cE-2xd4A:
undetectable		 5m5cE-2xd4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 4 GLN A 236
GLN A 211
PRO A 233
ALA A 210
 None
 1.05A 5odcA-2xd4A:
0.0
5odcG-2xd4A:
0.0		 5odcA-2xd4A:
23.24
5odcG-2xd4A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 5 PRO A 233
ALA A 210
GLN A 236
GLN A 211
 None
 1.05A 5odcA-2xd4A:
4.2
5odcG-2xd4A:
3.6		 5odcA-2xd4A:
23.24
5odcG-2xd4A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 12 PHE A 288
GLY A 266
GLY A  91
ILE A  67
GLU A  12
 None
 1.17A 5ul4A-2xd4A:
4.8		 5ul4A-2xd4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 8 THR A 293
GLN A 294
THR A 381
SER A 232
 None
 1.09A 6c06C-2xd4A:
undetectable		 6c06C-2xd4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 4 GLU A  83
VAL A  89
LEU A 312
THR A 265
 None
 1.27A 6dynA-2xd4A:
0.0		 6dynA-2xd4A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		4 / 5 GLU A  83
VAL A  89
LEU A 312
THR A 265
 None
 1.25A 6dyoA-2xd4A:
undetectable		 6dyoA-2xd4A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Bacillus
subtilis) 		5 / 8 GLY A  10
PHE A 359
GLY A 229
SER A 328
ALA A 326
 None
 1.49A 6hu9H-2xd4A:
undetectable
6hu9e-2xd4A:
undetectable		 6hu9H-2xd4A:
14.02
6hu9e-2xd4A:
16.22