SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xd7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		3 / 3 THR A 325
GLU A 291
ASP A 340
 None
 0.75A 1nt2A-2xd7A:
undetectable		 1nt2A-2xd7A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		5 / 12 PHE A 183
SER A 202
PHE A 354
LEU A 268
VAL A 273
 None
 1.32A 1q23C-2xd7A:
undetectable		 1q23C-2xd7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		5 / 11 PHE A 183
SER A 202
PHE A 354
LEU A 268
VAL A 273
 None
 1.33A 1q23L-2xd7A:
undetectable		 1q23L-2xd7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		3 / 3 ASP A 339
THR A 325
GLU A 291
 None
 0.76A 2zifB-2xd7A:
undetectable		 2zifB-2xd7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		5 / 10 PHE A 183
SER A 202
PHE A 354
LEU A 268
VAL A 273
 None
 1.23A 3u9fE-2xd7A:
undetectable		 3u9fE-2xd7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		5 / 10 PHE A 183
SER A 202
PHE A 354
LEU A 268
VAL A 273
 None
 1.24A 3u9fK-2xd7A:
undetectable		 3u9fK-2xd7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		5 / 12 PHE A 183
SER A 202
PHE A 354
LEU A 268
VAL A 273
 None
 1.28A 3u9fJ-2xd7A:
undetectable
3u9fL-2xd7A:
undetectable		 3u9fJ-2xd7A:
21.40
3u9fL-2xd7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		5 / 10 PHE A 183
SER A 202
PHE A 354
LEU A 268
VAL A 273
 None
 1.31A 3u9fR-2xd7A:
undetectable		 3u9fR-2xd7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		4 / 5 ALA A 336
ILE A 294
LEU A 298
LYS A 295
 None
 1.13A 4g19A-2xd7A:
undetectable		 4g19A-2xd7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		5 / 12 ALA A 261
SER A 263
ILE A 294
ASN A 296
PRO A 218
 None
 1.30A 4rtpA-2xd7A:
undetectable		 4rtpA-2xd7A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		4 / 8 ILE A 274
THR A 330
VAL A 329
GLU A 291
 None
 1.00A 6fbvC-2xd7A:
undetectable		 6fbvC-2xd7A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens) 		5 / 11 ILE A 294
HIS A 337
LEU A 197
SER A 344
ALA A 301
 None
 1.35A 6ieyA-2xd7A:
2.9
6ieyB-2xd7A:
3.2		 6ieyA-2xd7A:
18.10
6ieyB-2xd7A:
18.10