SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		4 / 5 ILE A  73
ILE A 129
TYR A 130
GLU A 128
 1B0  A1148 ( 4.1A)
None
None
None
 1.12A 4a99D-2xdeA:
undetectable		 4a99D-2xdeA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		4 / 6 VAL A  36
LEU A 138
ILE A 141
VAL A  59
 None
 0.93A 4a9kA-2xdeA:
undetectable		 4a9kA-2xdeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		4 / 5 VAL A  36
LEU A 138
ILE A 141
VAL A  59
 None
 0.71A 4a9kB-2xdeA:
undetectable		 4a9kB-2xdeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		4 / 7 PRO A  99
ASP A 103
SER A 102
TRP A  80
 None
 1.21A 4k7gB-2xdeA:
undetectable		 4k7gB-2xdeA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		5 / 11 PHE A  32
VAL A  59
TRP A  23
ILE A  73
PHE A  40
 None
None
None
1B0  A1148 ( 4.1A)
None
 1.31A 5hw8B-2xdeA:
undetectable		 5hw8B-2xdeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		5 / 11 PHE A  32
VAL A  59
TRP A  23
ILE A  73
PHE A  40
 None
None
None
1B0  A1148 ( 4.1A)
None
 1.21A 5hw8D-2xdeA:
undetectable		 5hw8D-2xdeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		4 / 6 PRO A  17
THR A  19
ASN A  21
LYS A  25
 None
 0.63A 5xxiA-2xdeA:
undetectable		 5xxiA-2xdeA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		5 / 12 PHE A  40
ILE A 134
LEU A  56
GLY A  46
ALA A  47
 None
None
1B0  A1148 (-4.1A)
None
None
 1.24A 5zwrA-2xdeA:
undetectable		 5zwrA-2xdeA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		5 / 10 SER A 109
LEU A  52
ASP A  51
ILE A 124
PRO A  99
 None
 1.42A 6dlzB-2xdeA:
undetectable
6dlzC-2xdeA:
undetectable		 6dlzB-2xdeA:
19.42
6dlzC-2xdeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		5 / 11 ILE A 124
PRO A  99
SER A 109
LEU A  52
ASP A  51
 None
 1.42A 6dlzA-2xdeA:
undetectable
6dlzD-2xdeA:
undetectable		 6dlzA-2xdeA:
19.42
6dlzD-2xdeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		5 / 10 SER A 109
LEU A  52
ASP A  51
ILE A 124
PRO A  99
 None
 1.42A 6dm1B-2xdeA:
undetectable
6dm1C-2xdeA:
undetectable		 6dm1B-2xdeA:
19.42
6dm1C-2xdeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xde GAG POLYPROTEIN
(Human
immunodeficiency
virus
1) 		5 / 11 ILE A 124
PRO A  99
SER A 109
LEU A  52
ASP A  51
 None
 1.41A 6dm1A-2xdeA:
undetectable
6dm1D-2xdeA:
undetectable		 6dm1A-2xdeA:
19.42
6dm1D-2xdeA:
19.42