SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2xdh COHESIN
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  71
THR A   6
VAL A 145
LEU A  38
ILE A  75
 None
 1.30A 1kqwA-2xdhA:
undetectable		 1kqwA-2xdhA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 2xdh COHESIN
(Archaeoglobus
fulgidus) 		5 / 11 ALA A  30
THR A   6
ILE A   8
ILE A  81
VAL A 145
 None
 1.11A 2qhfA-2xdhA:
undetectable		 2qhfA-2xdhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2xdh COHESIN
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  36
VAL A 143
LEU A  38
THR A 147
LEU A 130
 None
 1.03A 5tiwA-2xdhA:
undetectable		 5tiwA-2xdhA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2xdh COHESIN
(Archaeoglobus
fulgidus) 		5 / 11 ALA A 127
SER A  41
VAL A 145
ILE A 133
ILE A  36
 None
 1.03A 5y80A-2xdhA:
undetectable		 5y80A-2xdhA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 2xdh COHESIN
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  36
VAL A 143
LEU A  38
THR A 147
LEU A 130
 None
 1.05A 6b54A-2xdhA:
undetectable		 6b54A-2xdhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2xdh COHESIN
(Archaeoglobus
fulgidus) 		5 / 9 LEU A  87
SER A  86
THR A  57
VAL A  33
ILE A  27
 None
 1.26A 6ef6A-2xdhA:
undetectable		 6ef6A-2xdhA:
17.51