SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 465
ILE A 158
SER A 226
THR A 469
 None
TOE  A1492 (-4.4A)
None
None
 1.24A 1h7xA-2xdrA:
undetectable		 1h7xA-2xdrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 465
ILE A 158
SER A 226
THR A 469
 None
TOE  A1492 (-4.4A)
None
None
 1.26A 1h7xB-2xdrA:
undetectable		 1h7xB-2xdrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 465
ILE A 158
SER A 226
THR A 469
 None
TOE  A1492 (-4.4A)
None
None
 1.25A 1h7xC-2xdrA:
undetectable		 1h7xC-2xdrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 465
ILE A 158
SER A 226
THR A 469
 None
TOE  A1492 (-4.4A)
None
None
 1.25A 1h7xD-2xdrA:
2.6		 1h7xD-2xdrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 265
ASP A 264
PHE A 262
ILE A 431
ILE A 260
 None
 1.11A 1j3jA-2xdrA:
undetectable		 1j3jA-2xdrA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 265
ASP A 264
PHE A 262
ILE A 431
ILE A 260
 None
 1.08A 2bl9A-2xdrA:
undetectable		 2bl9A-2xdrA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 265
ASP A 264
PHE A 262
ILE A 431
ILE A 260
 None
 1.16A 2blaA-2xdrA:
undetectable		 2blaA-2xdrA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 127
GLU A 126
ILE A 128
PRO A 129
 None
 0.99A 2fcnA-2xdrA:
undetectable		 2fcnA-2xdrA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 163
VAL A 204
ALA A 189
TYR A 192
LEU A  79
 None
 1.19A 2japA-2xdrA:
5.4		 2japA-2xdrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 163
VAL A 204
ALA A 189
TYR A 192
LEU A  79
 None
 1.17A 2japB-2xdrA:
5.4		 2japB-2xdrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 163
VAL A 204
ALA A 189
TYR A 192
LEU A  79
 None
 1.18A 2japC-2xdrA:
5.4		 2japC-2xdrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 163
VAL A 204
ALA A 189
TYR A 192
LEU A  79
 None
 1.16A 2japD-2xdrA:
5.3		 2japD-2xdrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 188
TYR A 192
GLY A 196
 None
 0.61A 2ocuA-2xdrA:
undetectable		 2ocuA-2xdrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 265
ASP A 264
PHE A 262
ILE A 431
ILE A 260
 None
 1.09A 3clbB-2xdrA:
undetectable		 3clbB-2xdrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  89
PRO A 177
VAL A 204
THR A 206
VAL A  38
 None
 1.25A 3cwkA-2xdrA:
undetectable		 3cwkA-2xdrA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   9
LEU A 205
VAL A 204
SER A  52
VAL A  16
 None
 1.32A 3m7rA-2xdrA:
undetectable		 3m7rA-2xdrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 265
ASP A 264
PHE A 262
ILE A 431
ILE A 260
 None
 1.11A 3qgtA-2xdrA:
undetectable		 3qgtA-2xdrA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 428
HIS A 432
ILE A 431
 None
 0.62A 3u52A-2xdrA:
undetectable
3u52C-2xdrA:
undetectable		 3u52A-2xdrA:
21.72
3u52C-2xdrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BCS_A_ACTA1126_0
(CHIMERIC AVIDIN)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 THR A 206
GLN A  39
ARG A  40
THR A  23
 None
 1.44A 4bcsA-2xdrA:
0.0		 4bcsA-2xdrA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 364
ASP A 360
GLY A 361
VAL A 358
 None
 0.92A 4c5nA-2xdrA:
4.1		 4c5nA-2xdrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 103
THR A  94
THR A  91
ALA A  87
TYR A 154
 None
None
None
None
TOE  A1492 ( 4.1A)
 1.41A 4dajB-2xdrA:
0.0		 4dajB-2xdrA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 116
THR A 469
GLU A 450
 None
 0.76A 4df3A-2xdrA:
3.9		 4df3A-2xdrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 116
THR A 469
GLU A 450
 None
 0.79A 4df3B-2xdrA:
3.8		 4df3B-2xdrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 293
GLY A 344
ARG A 378
ARG A 296
GLN A 347
 None
 1.16A 4dx7A-2xdrA:
0.0		 4dx7A-2xdrA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 326
PRO A 327
GLN A 284
 None
 0.31A 4oltB-2xdrA:
undetectable		 4oltB-2xdrA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 399
ILE A 395
VAL A 420
ARG A 296
THR A 375
 None
 0.92A 4q5mA-2xdrA:
undetectable		 4q5mA-2xdrA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 326
PRO A 327
GLN A 284
 None
 0.29A 4qwpB-2xdrA:
undetectable		 4qwpB-2xdrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  75
LEU A 113
ALA A 110
LEU A 167
ALA A 164
 None
 1.19A 4zbrA-2xdrA:
undetectable		 4zbrA-2xdrA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A 411
ALA A 252
GLU A 387
THR A 290
GLY A 289
 None
GOL  A1491 ( 4.1A)
None
None
None
 1.03A 4zjoD-2xdrA:
undetectable		 4zjoD-2xdrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 103
THR A  94
THR A  91
ALA A  87
TYR A 154
 None
None
None
None
TOE  A1492 ( 4.1A)
 1.50A 5dsgA-2xdrA:
0.0		 5dsgA-2xdrA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 7 ALA A 159
GLU A 464
GLY A 150
SER A 226
GLY A 148
 None
GOL  A1491 (-4.3A)
NDP  A5502 (-4.5A)
None
None
 1.35A 5e26A-2xdrA:
undetectable
5e26B-2xdrA:
undetectable		 5e26A-2xdrA:
22.93
5e26B-2xdrA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 471
ALA A 122
ILE A 123
GLU A 124
 None
 0.65A 5mvmA-2xdrA:
undetectable
5mvmB-2xdrA:
undetectable		 5mvmA-2xdrA:
11.49
5mvmB-2xdrA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 165
GLU A 464
ARG A 463
THR A 469
 None
GOL  A1491 (-4.3A)
None
None
 1.27A 5uxcA-2xdrA:
undetectable		 5uxcA-2xdrA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  87
THR A  91
THR A  94
TRP A 152
 None
 0.80A 5x2tI-2xdrA:
undetectable
5x2tJ-2xdrA:
undetectable
5x2tK-2xdrA:
undetectable
5x2tL-2xdrA:
undetectable		 5x2tI-2xdrA:
16.38
5x2tJ-2xdrA:
16.53
5x2tK-2xdrA:
16.38
5x2tL-2xdrA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 328
THR A 323
ASN A 324
 None
 0.52A 6baaE-2xdrA:
undetectable		 6baaE-2xdrA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 328
THR A 323
ASN A 324
 None
 0.53A 6baaF-2xdrA:
undetectable		 6baaF-2xdrA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 328
THR A 323
ASN A 324
 None
 0.53A 6baaG-2xdrA:
2.3		 6baaG-2xdrA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 328
THR A 323
ASN A 324
 None
 0.53A 6baaH-2xdrA:
undetectable		 6baaH-2xdrA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ILE A  27
THR A  26
THR A  23
GLU A   6
 None
K  A1493 (-4.1A)
None
None
 1.15A 6c06C-2xdrA:
undetectable		 6c06C-2xdrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 167
GLY A  56
GLY A 200
GLY A  13
TYR A 192
 None
 1.11A 6ce2B-2xdrA:
undetectable		 6ce2B-2xdrA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 MET A 173
ALA A 185
LEU A 188
ALA A 189
 None
 0.86A 6fosB-2xdrA:
undetectable		 6fosB-2xdrA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 266
ASP A 268
GLN A 298
LYS A 305
 None
 1.32A 6g31L-2xdrA:
undetectable		 6g31L-2xdrA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2xdr BETAINE ALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 148
GLY A 209
GLY A 213
VAL A 237
ALA A  41
 None
NDP  A5502 (-2.9A)
NDP  A5502 (-3.7A)
NDP  A5502 (-4.3A)
None
 1.09A 6nj9K-2xdrA:
2.5		 6nj9K-2xdrA:
24.02