SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xe5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 6 ARG A 132
ASP A  89
THR A 130
ASP A  99
 None
 0.94A 2j2pE-2xe5A:
undetectable
2j2pF-2xe5A:
undetectable		 2j2pE-2xe5A:
22.13
2j2pF-2xe5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 6 ARG A 243
GLY A 245
ALA A 327
LEU A 208
 None
 0.98A 3bgdA-2xe5A:
undetectable		 3bgdA-2xe5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 4 GLY A  54
TYR A  53
GLY A  79
ASP A  89
 None
 0.70A 3kl3A-2xe5A:
undetectable		 3kl3A-2xe5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 7 GLY A  42
PHE A 128
PHE A  77
GLY A  79
 None
 0.98A 3ko0M-2xe5A:
undetectable
3ko0P-2xe5A:
undetectable		 3ko0M-2xe5A:
15.74
3ko0P-2xe5A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 8 GLY A  42
PHE A 128
PHE A  77
GLY A  79
 None
 0.98A 3ko0O-2xe5A:
undetectable
3ko0Q-2xe5A:
undetectable		 3ko0O-2xe5A:
15.74
3ko0Q-2xe5A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		5 / 12 LEU A 282
ARG A 284
GLY A 279
SER A 277
LEU A 247
 None
 1.01A 3okxB-2xe5A:
undetectable		 3okxB-2xe5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 6 ASP A 105
GLY A 111
ASP A 113
THR A 114
 SO4  A1349 ( 4.3A)
None
None
None
 1.02A 3vqrA-2xe5A:
undetectable		 3vqrA-2xe5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 5 ASP A 105
GLY A 111
ASP A 113
THR A 114
 SO4  A1349 ( 4.3A)
None
None
None
 1.04A 3vqrB-2xe5A:
undetectable		 3vqrB-2xe5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 5 ASP A 202
GLU A 159
GLY A 160
GLN A 172
 None
 1.35A 3w9tB-2xe5A:
undetectable		 3w9tB-2xe5A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 5 ASP A 202
GLU A 159
GLY A 158
ASP A 167
 None
 1.04A 3w9tD-2xe5A:
undetectable		 3w9tD-2xe5A:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 8 LYS A  16
TYR A  35
ARG A  74
ARG A 124
 SO4  A1348 (-2.9A)
None
SO4  A1349 (-3.7A)
SO4  A1349 (-3.1A)
 0.77A 4kr4C-2xe5A:
38.2		 4kr4C-2xe5A:
54.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 8 LYS A  16
TYR A  35
ASP A 105
ARG A 124
 SO4  A1348 (-2.9A)
None
SO4  A1349 ( 4.3A)
SO4  A1349 (-3.1A)
 0.71A 4kr4C-2xe5A:
38.2		 4kr4C-2xe5A:
54.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR8_C_DM1C401_1
(OUTER MEMBRANE
PROTEIN F)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		5 / 10 LYS A  16
TYR A  35
ARG A  74
TYR A  94
ARG A 124
 SO4  A1348 (-2.9A)
None
SO4  A1349 (-3.7A)
None
SO4  A1349 (-3.1A)
 0.87A 4kr8C-2xe5A:
40.5		 4kr8C-2xe5A:
54.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		5 / 12 ALA A 193
TYR A 218
SER A 196
SER A 195
GLY A 178
 None
OCT  A1347 (-4.6A)
None
None
None
 1.01A 4mmdB-2xe5A:
undetectable		 4mmdB-2xe5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		5 / 10 LEU A 318
LEU A 282
GLY A 245
VAL A 244
THR A 324
 None
 1.35A 4yb6A-2xe5A:
undetectable
4yb6D-2xe5A:
undetectable		 4yb6A-2xe5A:
22.43
4yb6D-2xe5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		5 / 10 LEU A 318
LEU A 282
GLY A 245
VAL A 244
THR A 324
 None
 1.35A 4yb6D-2xe5A:
undetectable
4yb6E-2xe5A:
undetectable		 4yb6D-2xe5A:
22.43
4yb6E-2xe5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 6 GLU A 109
GLY A 111
GLY A 112
ASP A 113
 None
 0.94A 5a06D-2xe5A:
undetectable		 5a06D-2xe5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 6 SER A  24
ASP A 320
ARG A 325
GLY A 328
 None
 1.04A 5cdqA-2xe5A:
undetectable
5cdqC-2xe5A:
undetectable
5cdqD-2xe5A:
undetectable		 5cdqA-2xe5A:
22.49
5cdqC-2xe5A:
22.49
5cdqD-2xe5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 7 GLY A  52
GLY A  54
PHE A  40
LEU A  11
 None
 0.88A 5izfA-2xe5A:
undetectable		 5izfA-2xe5A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		3 / 3 GLY A 112
ASP A 113
ASN A 330
 None
 0.61A 5jglA-2xe5A:
undetectable		 5jglA-2xe5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 4 SER A 180
ALA A 193
GLN A 122
THR A 101
 None
 1.47A 5n0rA-2xe5A:
undetectable		 5n0rA-2xe5A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 4 SER A 180
ALA A 193
GLN A 122
THR A 101
 None
 1.47A 5n0sA-2xe5A:
undetectable		 5n0sA-2xe5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 4 SER A 180
ALA A 193
GLN A 122
THR A 101
 None
 1.47A 5n0wA-2xe5A:
undetectable		 5n0wA-2xe5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 4 SER A 180
ALA A 193
GLN A 122
THR A 101
 None
 1.50A 5n0xA-2xe5A:
undetectable		 5n0xA-2xe5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		4 / 7 ASN A 164
ASP A 175
GLY A 176
ASN A 173
 None
 0.85A 5x7pA-2xe5A:
undetectable		 5x7pA-2xe5A:
14.66