SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		4 / 7 ALA A 206
LEU A 202
VAL A 174
MET A 175
 None
 0.71A 1hk2A-2xecA:
undetectable		 1hk2A-2xecA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		4 / 8 GLU A 204
SER A 246
ASP A 245
GLU A 207
 None
 1.17A 1knyA-2xecA:
undetectable
1knyB-2xecA:
undetectable		 1knyA-2xecA:
21.53
1knyB-2xecA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 SER A 228
GLY A   7
SER A 104
ILE A   6
LEU A 229
 None
 1.30A 1lhuA-2xecA:
undetectable		 1lhuA-2xecA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A  73
GLY A 221
VAL A 235
LEU A 242
LEU A  24
 None
 0.87A 1mx1C-2xecA:
2.5		 1mx1C-2xecA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 10 ALA A 121
HIS A  88
GLU A 148
HIS A  89
ALA A 114
 None
 1.24A 1r55A-2xecA:
4.6		 1r55A-2xecA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 9 VAL A 235
LEU A 242
PHE A  33
SER A 228
LEU A  24
 None
 1.31A 1wrkA-2xecA:
undetectable
1wrkB-2xecA:
undetectable		 1wrkA-2xecA:
12.69
1wrkB-2xecA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 GLY A 113
SER A 224
VAL A  91
ALA A 112
TYR A 144
 None
 1.45A 2avdA-2xecA:
undetectable		 2avdA-2xecA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 215
ILE A 212
ALA A 188
ALA A 124
VAL A 186
 None
 1.08A 2fr3A-2xecA:
undetectable		 2fr3A-2xecA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 11 ALA A 218
SER A 216
ALA A 220
GLY A 221
SER A 111
 None
 1.48A 2xfsB-2xecA:
undetectable		 2xfsB-2xecA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.94A 3nt1A-2xecA:
undetectable		 3nt1A-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.96A 3nt1B-2xecA:
undetectable		 3nt1B-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 1.05A 3pghD-2xecA:
undetectable		 3pghD-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		4 / 8 VAL A  95
VAL A  61
ILE A  64
LEU A  73
 None
 0.92A 4jq1B-2xecA:
2.2		 4jq1B-2xecA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 10 ILE A 191
VAL A 203
ALA A 218
CYH A 194
ALA A 217
 None
None
None
TRS  A 300 (-3.1A)
None
 1.07A 4lbgA-2xecA:
undetectable		 4lbgA-2xecA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 9 ILE A 191
VAL A 203
ALA A 218
CYH A 194
ALA A 217
 None
None
None
TRS  A 300 (-3.1A)
None
 1.03A 4lbgB-2xecA:
undetectable		 4lbgB-2xecA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		4 / 4 LEU A 226
SER A 224
LEU A 241
LEU A  25
 None
 1.10A 4n09A-2xecA:
3.2		 4n09A-2xecA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 GLY A 221
ALA A 222
LEU A 226
LEU A 229
LEU A 231
 None
 0.88A 4o1zA-2xecA:
undetectable		 4o1zA-2xecA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A  73
GLY A 221
LEU A  24
MET A  21
VAL A 203
 None
 1.46A 4okxA-2xecA:
undetectable		 4okxA-2xecA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 1.00A 4otyA-2xecA:
undetectable		 4otyA-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 1.00A 4otyB-2xecA:
undetectable		 4otyB-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		4 / 8 LEU A 119
GLY A 118
GLU A 207
ALA A 238
 None
 0.89A 4rjdA-2xecA:
undetectable
4rjdB-2xecA:
undetectable		 4rjdA-2xecA:
17.99
4rjdB-2xecA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.89A 4rrwA-2xecA:
undetectable		 4rrwA-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.87A 4rrwB-2xecA:
undetectable		 4rrwB-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.91A 4rrwC-2xecA:
undetectable		 4rrwC-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.98A 4rrwD-2xecA:
undetectable		 4rrwD-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.91A 4rrxA-2xecA:
undetectable		 4rrxA-2xecA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.91A 4rrxB-2xecA:
undetectable		 4rrxB-2xecA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.89A 4rrzA-2xecA:
undetectable		 4rrzA-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.87A 4rrzB-2xecA:
undetectable		 4rrzB-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.91A 4rrzC-2xecA:
undetectable		 4rrzC-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.98A 4rrzD-2xecA:
undetectable		 4rrzD-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		4 / 9 SER A 111
ALA A 114
GLU A 117
ILE A   6
 None
 0.91A 4xtaA-2xecA:
undetectable		 4xtaA-2xecA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		4 / 9 SER A 111
ALA A 114
GLU A 117
ILE A  72
 None
 0.75A 4xtaA-2xecA:
undetectable		 4xtaA-2xecA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 11 ALA A 178
LEU A 189
LEU A 129
MET A 197
LEU A 202
 None
 1.34A 5hyrB-2xecA:
undetectable		 5hyrB-2xecA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 1.01A 5ikqA-2xecA:
undetectable		 5ikqA-2xecA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 1.03A 5ikqB-2xecA:
undetectable		 5ikqB-2xecA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.87A 5ikrA-2xecA:
undetectable		 5ikrA-2xecA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.91A 5ikrB-2xecA:
undetectable		 5ikrB-2xecA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 1.08A 5jvzA-2xecA:
undetectable		 5jvzA-2xecA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 LEU A 122
SER A 224
ALA A 217
ALA A 220
GLY A 221
 None
 1.16A 5tzoB-2xecA:
undetectable		 5tzoB-2xecA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		5 / 12 MET A  21
ALA A 217
SER A 111
LEU A  73
ILE A 225
 None
 1.50A 5vlmA-2xecA:
undetectable		 5vlmA-2xecA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		4 / 6 PHE A  33
ILE A 225
LEU A   8
GLY A   7
 None
 0.95A 5x5qE-2xecA:
undetectable		 5x5qE-2xecA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2xec PUTATIVE MALEATE
ISOMERASE
(Nocardia
farcinica) 		4 / 8 LEU A 226
VAL A  71
ILE A   6
ARG A   4
 None
 0.91A 6cb4A-2xecA:
undetectable		 6cb4A-2xecA:
20.31