SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
5 / 12 THR A 616
ALA A 617
LEU A 659
LEU A 644
LEU A 647
None
1.12A 1errB-2xesA:
undetectable
1errB-2xesA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
5 / 11 LEU A 759
VAL A 751
GLU A 724
LEU A 689
LEU A 693
None
1.33A 1mrqA-2xesA:
undetectable
1mrqA-2xesA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
5 / 11 ALA A 721
ILE A 691
VAL A 717
LEU A 680
VAL A 679
None
0.91A 1rv7A-2xesA:
undetectable
1rv7B-2xesA:
undetectable
1rv7A-2xesA:
14.57
1rv7B-2xesA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
4 / 4 LEU A 601
LEU A 642
SER A 641
LEU A 637
None
1.13A 1ya3A-2xesA:
undetectable
1ya3A-2xesA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
5 / 12 LEU A 623
LEU A 613
LEU A 601
MET A 588
LEU A 569
None
1.42A 2oaxE-2xesA:
undetectable
2oaxE-2xesA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
3 / 3 GLN A 713
THR A 715
ASN A 712
None
0.89A 3v4tE-2xesA:
undetectable
3v4tE-2xesA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
5 / 10 ARG A 618
LEU A 692
LEU A 613
LEU A 620
ASN A 619
None
1.14A 3wdmB-2xesA:
undetectable
3wdmB-2xesA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
4 / 5 LEU A 601
PRO A 602
LEU A 604
ILE A 612
None
1.06A 4klrA-2xesA:
undetectable
4klrA-2xesA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
4 / 8 LEU A 644
SER A 738
VAL A 679
GLY A 685
None
0.91A 4klrB-2xesA:
undetectable
4klrB-2xesA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
4 / 7 GLU A 697
LEU A 693
LEU A 656
ARG A 657
None
0.79A 4wg0B-2xesA:
undetectable
4wg0C-2xesA:
undetectable
4wg0B-2xesA:
9.40
4wg0C-2xesA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
4 / 6 ARG A 578
ARG A 618
ASP A 611
ASP A 581
None
1.36A 4xqeB-2xesA:
undetectable
4xqeB-2xesA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
5 / 12 LEU A 689
ILE A 691
GLY A 685
LEU A 693
SER A 694
None
1.16A 5twjC-2xesA:
undetectable
5twjC-2xesA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()
2xes PROTEIN PAT1 HOMOLOG
1

(Homo
sapiens)
4 / 8 LEU A 689
LEU A 686
LEU A 726
LYS A 762
None
0.85A 6ce2A-2xesA:
undetectable
6ce2A-2xesA:
15.69