SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		4 / 4 GLY A 135
VAL A 137
TRP A  86
GLY A  57
 None
 1.33A 1ng8A-2xf4A:
undetectable		 1ng8A-2xf4A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		4 / 4 GLY A 135
VAL A 137
TRP A  86
GLY A  57
 None
 1.33A 1ng8B-2xf4A:
undetectable		 1ng8B-2xf4A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 12 GLY A 135
PHE A 139
GLY A 150
VAL A  29
ASP A  30
 None
 1.20A 2fqyA-2xf4A:
undetectable		 2fqyA-2xf4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_A_BEZA500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 10 ASP A  60
HIS A 132
ASP A 151
PHE A 163
HIS A 192
 ZN  A1211 ( 2.8A)
None
ZN  A1211 (-2.4A)
PG4  A1212 (-4.6A)
ZN  A1211 (-3.3A)
 0.83A 2q0jA-2xf4A:
18.4		 2q0jA-2xf4A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		6 / 11 ASP A  60
HIS A  61
HIS A 132
ASP A 151
PHE A 163
HIS A 192
 ZN  A1211 ( 2.8A)
ZN  A1211 (-3.3A)
None
ZN  A1211 (-2.4A)
PG4  A1212 (-4.6A)
ZN  A1211 (-3.3A)
 0.87A 2q0jB-2xf4A:
18.5		 2q0jB-2xf4A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 12 ILE A 148
ASN A   2
VAL A  29
VAL A 119
THR A  23
 None
 1.03A 2vn0A-2xf4A:
undetectable		 2vn0A-2xf4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 10 HIS A  56
HIS A  58
ASP A  60
HIS A 132
HIS A 192
 None
PG4  A1212 ( 3.7A)
ZN  A1211 ( 2.8A)
None
ZN  A1211 (-3.3A)
 0.79A 4c1dB-2xf4A:
4.9		 4c1dB-2xf4A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 11 HIS A  56
HIS A  58
ASP A  60
HIS A 132
HIS A 192
 None
PG4  A1212 ( 3.7A)
ZN  A1211 ( 2.8A)
None
ZN  A1211 (-3.3A)
 0.81A 4c1fA-2xf4A:
19.6
4c1fB-2xf4A:
6.3		 4c1fA-2xf4A:
23.36
4c1fB-2xf4A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 9 HIS A  56
HIS A  58
ASP A  60
HIS A 132
HIS A 192
 None
PG4  A1212 ( 3.7A)
ZN  A1211 ( 2.8A)
None
ZN  A1211 (-3.3A)
 0.77A 4c1hA-2xf4A:
20.2		 4c1hA-2xf4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 9 HIS A  58
ASP A  60
HIS A  56
GLY A 159
HIS A 192
 PG4  A1212 ( 3.7A)
ZN  A1211 ( 2.8A)
None
None
ZN  A1211 (-3.3A)
 1.06A 4c1hA-2xf4A:
20.2		 4c1hA-2xf4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		4 / 8 HIS A  58
ASP A  60
HIS A 132
HIS A 192
 PG4  A1212 ( 3.7A)
ZN  A1211 ( 2.8A)
None
ZN  A1211 (-3.3A)
 0.79A 4exsB-2xf4A:
18.5		 4exsB-2xf4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		4 / 5 TYR A   3
ILE A  18
ASN A  14
ILE A 148
 None
 1.02A 4jtpA-2xf4A:
undetectable		 4jtpA-2xf4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 12 CYH A 102
GLY A  33
GLY A  63
LEU A  59
ALA A  35
 None
 1.09A 4lg1C-2xf4A:
undetectable		 4lg1C-2xf4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 10 ILE A 189
GLN A  51
VAL A 117
LEU A 124
MET A   1
 None
 1.48A 4r3aB-2xf4A:
undetectable		 4r3aB-2xf4A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		4 / 8 HIS A  58
ASP A  60
HIS A 132
HIS A 192
 PG4  A1212 ( 3.7A)
ZN  A1211 ( 2.8A)
None
ZN  A1211 (-3.3A)
 0.77A 5a5zA-2xf4A:
5.0		 5a5zA-2xf4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		6 / 11 HIS A  56
HIS A  58
ASP A  60
HIS A  61
HIS A 132
HIS A 192
 None
PG4  A1212 ( 3.7A)
ZN  A1211 ( 2.8A)
ZN  A1211 (-3.3A)
None
ZN  A1211 (-3.3A)
 0.48A 5ayaA-2xf4A:
17.5		 5ayaA-2xf4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		4 / 5 ILE A  77
LEU A  87
HIS A 136
VAL A 137
 None
 1.21A 5jmnB-2xf4A:
undetectable		 5jmnB-2xf4A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 12 ILE A 153
LEU A 179
VAL A 158
GLY A 159
GLY A 131
 None
 1.15A 5nnaD-2xf4A:
undetectable		 5nnaD-2xf4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 10 ALA A  26
VAL A 119
PHE A 139
ILE A 148
GLN A  51
 None
 1.19A 5nukA-2xf4A:
undetectable		 5nukA-2xf4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 10 HIS A  56
HIS A  58
HIS A  61
HIS A 132
ASP A 151
 None
PG4  A1212 ( 3.7A)
ZN  A1211 (-3.3A)
None
ZN  A1211 (-2.4A)
 0.51A 5nzwA-2xf4A:
2.4		 5nzwA-2xf4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		5 / 12 MET A  96
ALA A  92
GLY A  89
LEU A  59
ASP A  83
 PG4  A1212 ( 3.9A)
PG4  A1212 (-3.7A)
None
None
None
 1.30A 5vlmF-2xf4A:
undetectable		 5vlmF-2xf4A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		4 / 8 HIS A  58
ASP A  60
HIS A 132
HIS A 192
 PG4  A1212 ( 3.7A)
ZN  A1211 ( 2.8A)
None
ZN  A1211 (-3.3A)
 0.84A 5zj8A-2xf4A:
18.7		 5zj8A-2xf4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE
(Salmonella
enterica) 		4 / 8 ASP A 151
HIS A 168
HIS A  56
ASP A 162
 ZN  A1211 (-2.4A)
None
None
None
 1.06A 6mn4A-2xf4A:
undetectable		 6mn4A-2xf4A:
23.40