SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 154
LEU A 160
LYS A 159
ILE A 270
THR A 307
 None
 1.00A 1ddsA-2xf8A:
undetectable		 1ddsA-2xf8A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 11 ILE A 154
LEU A 160
LYS A 159
ILE A 270
THR A 307
 None
 1.03A 1dhiB-2xf8A:
undetectable		 1dhiB-2xf8A:
20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 7 SER A 148
THR A 150
ASN A 152
CYH A 153
ASN A 313
 SO4  A 500 ( 4.0A)
SO4  A 500 (-3.2A)
None
None
None
 0.67A 1dssG-2xf8A:
43.1		 1dssG-2xf8A:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 8 SER A 148
THR A 150
ASN A 152
CYH A 153
ASN A 313
 SO4  A 500 ( 4.0A)
SO4  A 500 (-3.2A)
None
None
None
 0.69A 1dssR-2xf8A:
42.9		 1dssR-2xf8A:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 8 SER A 148
THR A 150
ASN A 152
CYH A 153
HIS A 176
 SO4  A 500 ( 4.0A)
SO4  A 500 (-3.2A)
None
None
SO4  A 500 (-4.7A)
 1.04A 1dssR-2xf8A:
42.9		 1dssR-2xf8A:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A  91
ILE A  25
TYR A 130
ASN A 319
LEU A  93
 None
 1.20A 1fm4A-2xf8A:
undetectable		 1fm4A-2xf8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		4 / 7 THR A 127
GLY A 213
THR A 151
ILE A 214
 None
 0.97A 1gtnF-2xf8A:
undetectable
1gtnG-2xf8A:
undetectable		 1gtnF-2xf8A:
14.86
1gtnG-2xf8A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		4 / 7 THR A 127
GLY A 213
THR A 151
ILE A 214
 None
 0.96A 1gtnJ-2xf8A:
undetectable
1gtnK-2xf8A:
undetectable		 1gtnJ-2xf8A:
14.86
1gtnK-2xf8A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 154
LEU A 160
LYS A 159
ILE A 270
THR A 307
 None
 0.99A 1ra3A-2xf8A:
undetectable		 1ra3A-2xf8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 154
LEU A 160
LYS A 159
ILE A 270
THR A 307
 None
 1.02A 1rd7B-2xf8A:
undetectable		 1rd7B-2xf8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 154
LEU A 160
LYS A 159
ILE A 270
THR A 307
 None
 0.99A 1rx7A-2xf8A:
undetectable		 1rx7A-2xf8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 154
LEU A 160
LYS A 159
ILE A 270
THR A 307
 None
 1.13A 1rx8A-2xf8A:
undetectable		 1rx8A-2xf8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 10 TYR A  20
LEU A  64
ILE A  30
ALA A  18
PHE A   8
 None
 1.14A 1xp0A-2xf8A:
undetectable		 1xp0A-2xf8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 10 PHE A  53
VAL A  66
ILE A  30
LEU A  64
PHE A   8
 None
 1.11A 1z11D-2xf8A:
undetectable		 1z11D-2xf8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		4 / 5 LEU A 117
ASN A 146
PHE A 317
VAL A  15
 None
None
3CD  A 600 (-3.7A)
None
 1.20A 2cizA-2xf8A:
undetectable		 2cizA-2xf8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLN A  80
LEU A  74
VAL A  92
ALA A 110
VAL A  89
 None
 1.39A 2g70A-2xf8A:
3.7		 2g70A-2xf8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A 172
GLN A 220
PHE A 221
ILE A 158
PHE A 225
 None
 1.45A 2vdyA-2xf8A:
undetectable		 2vdyA-2xf8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A 242
ILE A 228
ILE A 167
SER A 169
ASP A 241
 None
 1.04A 3axtA-2xf8A:
3.9		 3axtA-2xf8A:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 8 SER A 148
THR A 150
ASN A 152
CYH A 153
ASN A 313
 SO4  A 500 ( 4.0A)
SO4  A 500 (-3.2A)
None
None
None
 0.61A 3dmtC-2xf8A:
42.6		 3dmtC-2xf8A:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 8 SER A 148
THR A 150
ASN A 152
CYH A 153
HIS A 176
 SO4  A 500 ( 4.0A)
SO4  A 500 (-3.2A)
None
None
SO4  A 500 (-4.7A)
 1.01A 3dmtC-2xf8A:
42.6		 3dmtC-2xf8A:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 316
ASN A  14
ILE A 270
GLY A 131
GLN A 134
 None
 1.13A 3eeyA-2xf8A:
4.0		 3eeyA-2xf8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 316
ASN A  14
ILE A 270
GLY A 131
GLN A 134
 None
 1.14A 3eeyF-2xf8A:
3.6		 3eeyF-2xf8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 316
ASN A  14
ILE A 270
GLY A 131
GLN A 134
 None
 1.13A 3eeyH-2xf8A:
undetectable		 3eeyH-2xf8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 316
ASN A  14
ILE A 270
GLY A 131
GLN A 134
 None
 1.14A 3eeyI-2xf8A:
2.3		 3eeyI-2xf8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 10 ILE A 158
ILE A 155
VAL A 129
GLY A 131
VAL A 309
 None
 1.30A 3em0A-2xf8A:
undetectable		 3em0A-2xf8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 HIS A 108
ASP A  94
THR A  96
LEU A  79
LEU A  82
 None
None
3CD  A 600 ( 4.8A)
None
None
 1.28A 3g1uB-2xf8A:
5.2		 3g1uB-2xf8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 HIS A 108
ASP A  94
THR A  96
LEU A  79
LEU A  82
 None
None
3CD  A 600 ( 4.8A)
None
None
 1.25A 3g1uD-2xf8A:
5.2		 3g1uD-2xf8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 HIS A 108
ASP A  94
THR A  96
LEU A  79
LEU A  82
 None
None
3CD  A 600 ( 4.8A)
None
None
 1.27A 3n58C-2xf8A:
4.8		 3n58C-2xf8A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 HIS A 108
ASP A  94
THR A  96
LEU A  79
LEU A  82
 None
None
3CD  A 600 ( 4.8A)
None
None
 1.25A 3n58D-2xf8A:
4.6		 3n58D-2xf8A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		4 / 8 VAL A 255
LEU A 259
LEU A 308
THR A 307
 None
 0.79A 3roxA-2xf8A:
3.3		 3roxA-2xf8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		3 / 3 HIS A 303
SER A 169
GLU A 168
 None
 0.92A 3s8pA-2xf8A:
undetectable		 3s8pA-2xf8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ARG A  22
GLU A  24
THR A   0
 None
 0.84A 3v4tA-2xf8A:
undetectable		 3v4tA-2xf8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ASP A  94
GLY A   7
TYR A  99
 None
3CD  A 600 (-3.5A)
3CD  A 600 (-4.9A)
 0.78A 3w9tC-2xf8A:
undetectable		 3w9tC-2xf8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ASP A  94
GLY A   7
TYR A  99
 None
3CD  A 600 (-3.5A)
3CD  A 600 (-4.9A)
 0.78A 3w9tG-2xf8A:
undetectable		 3w9tG-2xf8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ASN A 236
ASP A 312
ASN A 313
 None
 0.69A 4agaA-2xf8A:
undetectable		 4agaA-2xf8A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A 172
GLN A 220
PHE A 221
ILE A 158
PHE A 225
 None
 1.38A 4c49B-2xf8A:
undetectable		 4c49B-2xf8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A 172
GLN A 220
PHE A 221
ILE A 158
PHE A 225
 None
 1.41A 4c49C-2xf8A:
undetectable		 4c49C-2xf8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A 172
GLN A 220
PHE A 221
ILE A 158
PHE A 225
 None
 1.40A 4c49D-2xf8A:
2.4		 4c49D-2xf8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 11 SER A 119
ILE A  11
ASP A 312
GLY A 316
PHE A 317
 3CD  A 600 (-3.4A)
3CD  A 600 (-4.2A)
None
None
3CD  A 600 (-3.7A)
 1.27A 4fogA-2xf8A:
undetectable		 4fogA-2xf8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 11 SER A 119
ILE A  11
ASP A 312
GLY A 316
PHE A 317
 3CD  A 600 (-3.4A)
3CD  A 600 (-4.2A)
None
None
3CD  A 600 (-3.7A)
 1.25A 4fogC-2xf8A:
undetectable		 4fogC-2xf8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 SER A 119
ILE A  11
ASP A 312
GLY A 316
PHE A 317
 3CD  A 600 (-3.4A)
3CD  A 600 (-4.2A)
None
None
3CD  A 600 (-3.7A)
 1.24A 4foxD-2xf8A:
undetectable		 4foxD-2xf8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 SER A 119
ILE A  11
ASP A 312
GLY A 316
PHE A 317
 3CD  A 600 (-3.4A)
3CD  A 600 (-4.2A)
None
None
3CD  A 600 (-3.7A)
 1.28A 4foxE-2xf8A:
undetectable		 4foxE-2xf8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 11 SER A 119
ILE A  11
ASP A 312
GLY A 316
PHE A 317
 3CD  A 600 (-3.4A)
3CD  A 600 (-4.2A)
None
None
3CD  A 600 (-3.7A)
 1.25A 4foxH-2xf8A:
undetectable		 4foxH-2xf8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 10 LEU A 242
LEU A 161
LEU A 258
ILE A 154
VAL A 271
 None
 1.37A 4mk4A-2xf8A:
4.2		 4mk4A-2xf8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 154
LEU A 160
LYS A 159
ILE A 270
THR A 307
 None
 1.12A 4x5gA-2xf8A:
undetectable		 4x5gA-2xf8A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A 227
THR A 174
THR A 208
THR A 151
GLY A 170
 None
SO4  A 500 ( 4.8A)
SO4  A 500 (-3.6A)
None
None
 1.15A 4ypmA-2xf8A:
undetectable		 4ypmA-2xf8A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		3 / 3 VAL A  28
THR A  26
ARG A   2
 None
 0.57A 5b2sB-2xf8A:
undetectable		 5b2sB-2xf8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		3 / 3 VAL A  28
THR A  26
ARG A   2
 None
 0.59A 5b2tB-2xf8A:
undetectable		 5b2tB-2xf8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A  12
ALA A 318
PHE A 317
ASN A   6
CYH A  95
 None
None
3CD  A 600 (-3.7A)
3CD  A 600 ( 4.3A)
None
 1.17A 5c8tB-2xf8A:
2.1		 5c8tB-2xf8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 214
VAL A 157
ALA A 290
VAL A 309
GLY A 316
 None
 1.01A 5igiA-2xf8A:
undetectable		 5igiA-2xf8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 214
VAL A 157
ALA A 290
VAL A 309
GLY A 316
 None
 1.02A 5igjA-2xf8A:
undetectable		 5igjA-2xf8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 214
VAL A 157
ALA A 290
VAL A 309
GLY A 316
 None
 1.02A 5igtA-2xf8A:
1.3		 5igtA-2xf8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		4 / 8 TRP A 315
ASN A  14
ALA A 318
HIS A  50
 None
 1.14A 5km8A-2xf8A:
undetectable
5km8B-2xf8A:
undetectable		 5km8A-2xf8A:
18.32
5km8B-2xf8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		4 / 6 HIS A 120
ASN A   6
VAL A 116
LEU A 124
 3CD  A 600 (-4.1A)
3CD  A 600 ( 4.3A)
None
None
 1.47A 5xdhA-2xf8A:
undetectable
5xdhC-2xf8A:
undetectable		 5xdhA-2xf8A:
13.77
5xdhC-2xf8A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		4 / 5 HIS A 120
ASN A   6
VAL A 116
LEU A 124
 3CD  A 600 (-4.1A)
3CD  A 600 ( 4.3A)
None
None
 1.47A 5xdhD-2xf8A:
undetectable		 5xdhD-2xf8A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		4 / 8 GLY A  12
ILE A  11
ASP A  47
HIS A  50
 None
3CD  A 600 (-4.2A)
None
None
 0.87A 6ag0A-2xf8A:
undetectable		 6ag0A-2xf8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE
(Escherichia
coli) 		4 / 8 GLY A  12
ILE A  11
ASP A  47
HIS A  50
 None
3CD  A 600 (-4.2A)
None
None
 0.85A 6ag0C-2xf8A:
undetectable		 6ag0C-2xf8A:
17.56