SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 4 ALA A 148
VAL A  36
ALA A 131
HIS A 152
 None
 1.21A 1q23F-2xfbA:
undetectable		 1q23F-2xfbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 4 ALA A 148
VAL A  36
ALA A 131
HIS A 152
 None
 1.19A 1q23K-2xfbA:
undetectable		 1q23K-2xfbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 ILE B 165
ARG B 150
THR B 190
LEU B  98
 None
 1.02A 2einN-2xfbB:
undetectable
2einW-2xfbB:
undetectable		 2einN-2xfbB:
20.65
2einW-2xfbB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 8 THR A  53
VAL A 108
ASN A 216
ALA A 236
 None
 1.13A 2ij7C-2xfbA:
undetectable		 2ij7C-2xfbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 11 ILE A 280
SER A 279
ILE A 278
LEU A 133
VAL A 144
 None
 0.84A 2kawA-2xfbA:
undetectable		 2kawA-2xfbA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 8 LEU A  38
LEU A  33
VAL A 163
GLY A 164
 None
 0.98A 2po5A-2xfbA:
undetectable		 2po5A-2xfbA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 8 LEU A  38
LEU A  33
VAL A 163
GLY A 164
 None
 0.81A 2po5B-2xfbA:
undetectable		 2po5B-2xfbA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA B 167
LEU B 147
ARG B 144
LEU B 175
PRO B 170
 None
 0.96A 2qxsA-2xfbB:
undetectable		 2qxsA-2xfbB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA B 167
LEU B 147
ARG B 144
LEU B 175
PRO B 170
 None
 0.91A 2qxsB-2xfbB:
undetectable		 2qxsB-2xfbB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 8 ALA A 336
ALA A 359
SER A 309
GLY A 313
 None
 0.91A 2vh3B-2xfbA:
undetectable		 2vh3B-2xfbA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus;
Chikungunya
virus) 		3 / 3 TYR B 220
GLU B 229
THR A 116
 None
 0.87A 2y7hB-2xfbB:
undetectable		 2y7hB-2xfbB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 11 ASN A   9
LEU A 251
ILE A 261
THR A 263
PRO A  40
 None
 1.36A 3a50B-2xfbA:
undetectable		 3a50B-2xfbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 ILE B 165
ARG B 150
THR B 190
LEU B  98
 None
 0.97A 3ag3A-2xfbB:
undetectable
3ag3J-2xfbB:
undetectable		 3ag3A-2xfbB:
20.65
3ag3J-2xfbB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 SER A 309
SER A 310
HIS A 386
 None
 0.74A 3mzeA-2xfbA:
undetectable		 3mzeA-2xfbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 PRO A  58
GLN A 102
PRO A  86
TYR A  93
 None
 1.19A 3vkxA-2xfbA:
undetectable		 3vkxA-2xfbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 ASP A 188
ARG A 123
LYS A 176
 None
 0.87A 3wipG-2xfbA:
2.7		 3wipG-2xfbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 4 TYR A 137
THR A 155
VAL A 144
ILE A 282
 None
 1.39A 4jx1F-2xfbA:
undetectable		 4jx1F-2xfbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 ASN B 363
GLU B 388
GLU B 366
GLU B 367
 None
 1.20A 4mj8C-2xfbB:
undetectable		 4mj8C-2xfbB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 LEU B 175
ILE B 101
LEU B  98
THR B 160
VAL B 114
 None
 0.96A 4nkvB-2xfbB:
undetectable		 4nkvB-2xfbB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 5 ILE A  55
PRO B 304
TYR A  93
VAL A  60
 None
 1.34A 4s0vA-2xfbA:
undetectable		 4s0vA-2xfbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA B 167
LEU B 147
ARG B 144
LEU B 175
PRO B 170
 None
 0.93A 4xi3A-2xfbB:
undetectable		 4xi3A-2xfbB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA B 167
LEU B 147
ARG B 144
LEU B 175
PRO B 170
 None
 0.89A 4xi3B-2xfbB:
undetectable		 4xi3B-2xfbB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus;
Chikungunya
virus) 		5 / 12 ASN B 103
SER A 113
GLU B 104
GLU A  50
VAL A 108
 None
 1.16A 5iqdC-2xfbB:
0.0		 5iqdC-2xfbB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 HIS B 195
ASN B 103
ALA B 105
 None
 0.62A 5n4tB-2xfbB:
undetectable		 5n4tB-2xfbB:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 GLY A 201
PHE A 240
ARG A 206
ASP A 202
 None
 0.90A 5n5dB-2xfbA:
undetectable		 5n5dB-2xfbA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus;
Chikungunya
virus) 		4 / 5 GLU B 230
LYS B 318
GLU B 232
GLU A 109
 None
 1.14A 5onlA-2xfbB:
undetectable		 5onlA-2xfbB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 ILE B 165
ARG B 150
THR B 190
LEU B  98
 None
 0.93A 5xdqN-2xfbB:
undetectable
5xdqW-2xfbB:
undetectable		 5xdqN-2xfbB:
20.65
5xdqW-2xfbB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 9 ILE A 142
ALA A 159
LEU A  29
PRO A  14
ARG A 134
 None
 1.46A 5z6lA-2xfbA:
undetectable		 5z6lA-2xfbA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 ILE B 165
ARG B 150
THR B 190
LEU B  98
 None
 0.96A 5z86N-2xfbB:
undetectable
5z86W-2xfbB:
undetectable		 5z86N-2xfbB:
20.65
5z86W-2xfbB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 ILE B 165
ARG B 150
THR B 190
LEU B  98
 None
 1.00A 5zcoN-2xfbB:
undetectable
5zcoW-2xfbB:
undetectable		 5zcoN-2xfbB:
20.65
5zcoW-2xfbB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 LEU B 312
THR B 294
ASN B 295
 None
 0.58A 6baaE-2xfbB:
undetectable		 6baaE-2xfbB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 LEU B 312
THR B 294
ASN B 295
 None
 0.58A 6baaF-2xfbB:
undetectable		 6baaF-2xfbB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 LEU B 312
THR B 294
ASN B 295
 None
 0.60A 6baaG-2xfbB:
undetectable		 6baaG-2xfbB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 LEU B 312
THR B 294
ASN B 295
 None
 0.60A 6baaH-2xfbB:
undetectable		 6baaH-2xfbB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 TYR B 301
PRO B 304
LEU B 305
 None
 0.94A 6beoA-2xfbB:
undetectable		 6beoA-2xfbB:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 2xfb E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ILE B 319
ILE B 321
VAL B 233
ILE B 231
PRO B 139
 None
 1.06A 6hlpA-2xfbB:
undetectable		 6hlpA-2xfbB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 2xfb E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus;
Chikungunya
virus) 		4 / 5 GLU B 230
LYS B 318
GLU B 232
GLU A 109
 None
 1.14A 6hrjA-2xfbB:
0.0		 6hrjA-2xfbB:
18.75