SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA B 167
LEU B 147
ARG B 144
LEU B 175
PRO B 170
 None
 0.75A 2qxsA-2xfcB:
undetectable		 2qxsA-2xfcB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA B 167
LEU B 147
ARG B 144
LEU B 175
PRO B 170
 None
 0.73A 2qxsB-2xfcB:
undetectable		 2qxsB-2xfcB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 ILE B 165
ARG B 150
THR B 190
LEU B  98
 None
 0.93A 3ag3A-2xfcB:
undetectable
3ag3J-2xfcB:
undetectable		 3ag3A-2xfcB:
20.34
3ag3J-2xfcB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA B 167
LEU B 147
ARG B 144
LEU B 175
PRO B 170
 None
 0.78A 4xi3A-2xfcB:
undetectable		 4xi3A-2xfcB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ALA B 167
LEU B 147
ARG B 144
LEU B 175
PRO B 170
 None
 0.74A 4xi3B-2xfcB:
undetectable		 4xi3B-2xfcB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 HIS B 195
ASN B 103
ALA B 105
 None
 0.63A 5n4tB-2xfcB:
undetectable		 5n4tB-2xfcB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 7 ILE B 165
ARG B 150
THR B 190
LEU B  98
 None
 0.94A 5xdqN-2xfcB:
undetectable
5xdqW-2xfcB:
undetectable		 5xdqN-2xfcB:
20.34
5xdqW-2xfcB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 ILE B 165
ARG B 150
THR B 190
LEU B  98
 None
 0.96A 5z86N-2xfcB:
undetectable
5z86W-2xfcB:
undetectable		 5z86N-2xfcB:
20.34
5z86W-2xfcB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		4 / 6 ILE B 165
ARG B 150
THR B 190
LEU B  98
 None
 1.00A 5zcoN-2xfcB:
undetectable
5zcoW-2xfcB:
undetectable		 5zcoN-2xfcB:
20.34
5zcoW-2xfcB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		3 / 3 TYR B 301
PRO B 304
LEU B 305
 None
 0.93A 6beoA-2xfcB:
undetectable		 6beoA-2xfcB:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 2xfc E2 ENVELOPE
GLYCOPROTEIN
(Chikungunya
virus) 		5 / 12 ILE B 319
ILE B 321
VAL B 233
ILE B 231
PRO B 139
 None
 1.07A 6hlpA-2xfcB:
undetectable		 6hlpA-2xfcB:
20.63