SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 2xfs ORF12
(Streptomyces
clavuligerus) 		6 / 12 LYS A 176
SER A 234
ASN A 236
LYS A 375
GLY A 377
SER A 378
 None
J01  A 600 (-3.4A)
None
J01  A 600 ( 4.4A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
 0.49A 1ymxB-2xfsA:
22.6		 1ymxB-2xfsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		4 / 7 MET A 230
ARG A 245
LEU A 246
VAL A 184
 None
 1.37A 2hrcA-2xfsA:
undetectable		 2hrcA-2xfsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		6 / 12 PHE A 385
PHE A 276
ALA A 173
SER A 234
GLY A 316
LEU A 315
 J01  A 600 (-4.7A)
None
J01  A 600 ( 4.0A)
J01  A 600 (-3.4A)
None
None
 1.16A 2hw2A-2xfsA:
undetectable		 2hw2A-2xfsA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2xfs ORF12
(Streptomyces
clavuligerus) 		4 / 7 GLY A 414
LEU A 401
PHE A 385
PHE A 374
 J01  A 600 ( 4.7A)
None
J01  A 600 (-4.7A)
None
 1.01A 2vctD-2xfsA:
undetectable		 2vctD-2xfsA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XF3_A_J01A500_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		10 / 10 HIS A  84
TRP A  91
VAL A  93
ILE A 103
LEU A 362
LEU A 415
ARG A 418
GLY A 419
ALA A 422
LYS A 423
 J01  A 500 (-3.5A)
J01  A 500 (-4.6A)
None
None
None
None
J01  A 600 ( 2.8A)
J01  A 500 (-3.4A)
J01  A 500 (-3.4A)
J01  A 500 (-3.7A)
 0.14A 2xf3A-2xfsA:
67.5		 2xf3A-2xfsA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XF3_A_J01A600_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		10 / 11 LYS A  89
THR A 209
SER A 234
TYR A 359
ALA A 376
GLY A 377
SER A 378
MET A 383
PHE A 385
ARG A 418
 J01  A 600 (-2.8A)
J01  A 600 (-3.2A)
J01  A 600 (-3.4A)
J01  A 600 (-4.8A)
J01  A 600 (-3.5A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
J01  A 600 ( 3.9A)
J01  A 600 (-4.7A)
J01  A 600 ( 2.8A)
 0.12A 2xf3A-2xfsA:
67.5		 2xf3A-2xfsA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XF3_B_J01B500_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		9 / 9 HIS A  84
TRP A  91
VAL A  93
ILE A 103
LEU A 362
ARG A 418
GLY A 419
ALA A 422
LYS A 423
 J01  A 500 (-3.5A)
J01  A 500 (-4.6A)
None
None
None
J01  A 600 ( 2.8A)
J01  A 500 (-3.4A)
J01  A 500 (-3.4A)
J01  A 500 (-3.7A)
 0.26A 2xf3B-2xfsA:
65.6		 2xf3B-2xfsA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XF3_B_J01B600_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		10 / 11 LYS A  89
THR A 209
SER A 234
TYR A 359
ALA A 376
GLY A 377
SER A 378
MET A 383
PHE A 385
ARG A 418
 J01  A 600 (-2.8A)
J01  A 600 (-3.2A)
J01  A 600 (-3.4A)
J01  A 600 (-4.8A)
J01  A 600 (-3.5A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
J01  A 600 ( 3.9A)
J01  A 600 (-4.7A)
J01  A 600 ( 2.8A)
 0.15A 2xf3B-2xfsA:
65.6		 2xf3B-2xfsA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XH9_A_J01A1436_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		8 / 8 HIS A  84
TRP A  91
VAL A  93
LEU A 362
ARG A 418
GLY A 419
ALA A 422
LYS A 423
 J01  A 500 (-3.5A)
J01  A 500 (-4.6A)
None
None
J01  A 600 ( 2.8A)
J01  A 500 (-3.4A)
J01  A 500 (-3.4A)
J01  A 500 (-3.7A)
 0.14A 2xh9A-2xfsA:
68.5		 2xh9A-2xfsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XH9_A_J01A1437_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		9 / 11 LYS A  89
THR A 209
SER A 234
TYR A 359
ALA A 376
GLY A 377
MET A 383
PHE A 385
ARG A 418
 J01  A 600 (-2.8A)
J01  A 600 (-3.2A)
J01  A 600 (-3.4A)
J01  A 600 (-4.8A)
J01  A 600 (-3.5A)
J01  A 600 ( 3.8A)
J01  A 600 ( 3.9A)
J01  A 600 (-4.7A)
J01  A 600 ( 2.8A)
 0.10A 2xh9A-2xfsA:
68.5		 2xh9A-2xfsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XH9_A_J01A1437_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 11 SER A 378
THR A 209
ALA A 173
GLY A 377
ALA A 376
 J01  A 600 (-3.4A)
J01  A 600 (-3.2A)
J01  A 600 ( 4.0A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.5A)
 1.18A 2xh9A-2xfsA:
68.5		 2xh9A-2xfsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XH9_B_J01B1436_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		9 / 9 HIS A  84
TRP A  91
VAL A  93
ILE A 103
LEU A 362
ARG A 418
GLY A 419
ALA A 422
LYS A 423
 J01  A 500 (-3.5A)
J01  A 500 (-4.6A)
None
None
None
J01  A 600 ( 2.8A)
J01  A 500 (-3.4A)
J01  A 500 (-3.4A)
J01  A 500 (-3.7A)
 0.26A 2xh9B-2xfsA:
65.6		 2xh9B-2xfsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XH9_B_J01B1437_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		8 / 10 LYS A  89
THR A 209
SER A 234
TYR A 359
ALA A 376
GLY A 377
PHE A 385
ARG A 418
 J01  A 600 (-2.8A)
J01  A 600 (-3.2A)
J01  A 600 (-3.4A)
J01  A 600 (-4.8A)
J01  A 600 (-3.5A)
J01  A 600 ( 3.8A)
J01  A 600 (-4.7A)
J01  A 600 ( 2.8A)
 0.15A 2xh9B-2xfsA:
65.6		 2xh9B-2xfsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XH9_B_J01B1437_1
(ORF12)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 10 SER A 378
THR A 209
ALA A 173
GLY A 377
ALA A 376
 J01  A 600 (-3.4A)
J01  A 600 (-3.2A)
J01  A 600 ( 4.0A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.5A)
 1.20A 2xh9B-2xfsA:
65.6		 2xh9B-2xfsA:
99.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2xfs ORF12
(Streptomyces
clavuligerus) 		4 / 6 ARG A 285
PRO A 283
GLY A 281
TRP A 280
 None
 1.44A 2y7pA-2xfsA:
undetectable		 2y7pA-2xfsA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 LEU A 340
LEU A 337
MET A 328
GLY A 259
HIS A 260
 None
 1.09A 2yjaB-2xfsA:
undetectable		 2yjaB-2xfsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xfs ORF12
(Streptomyces
clavuligerus) 		3 / 3 LEU A 104
LEU A 119
ARG A  73
 None
 0.70A 3hcnB-2xfsA:
undetectable		 3hcnB-2xfsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		6 / 12 LYS A 176
SER A 234
ASN A 236
LYS A 375
GLY A 377
SER A 378
 None
J01  A 600 (-3.4A)
None
J01  A 600 ( 4.4A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
 0.50A 3hlwA-2xfsA:
22.7		 3hlwA-2xfsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 SER A 234
ASN A 236
LYS A 375
GLY A 377
SER A 378
 J01  A 600 (-3.4A)
None
J01  A 600 ( 4.4A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
 0.37A 3hlwB-2xfsA:
22.8		 3hlwB-2xfsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 LYS A 176
ASN A 236
LYS A 375
GLY A 377
SER A 378
 None
None
J01  A 600 ( 4.4A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
 0.53A 3huoA-2xfsA:
22.5		 3huoA-2xfsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 LYS A 176
ASN A 236
LYS A 375
GLY A 377
SER A 378
 None
None
J01  A 600 ( 4.4A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
 0.53A 3huoB-2xfsA:
22.7		 3huoB-2xfsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		4 / 8 LYS A  75
TYR A 102
LEU A 104
LEU A  40
 None
 0.88A 3lm8A-2xfsA:
undetectable
3lm8C-2xfsA:
undetectable		 3lm8A-2xfsA:
17.69
3lm8C-2xfsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		6 / 12 LYS A 176
SER A 234
ASN A 236
LYS A 375
GLY A 377
SER A 378
 None
J01  A 600 (-3.4A)
None
J01  A 600 ( 4.4A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
 0.55A 3q07A-2xfsA:
22.7		 3q07A-2xfsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		6 / 12 LYS A 176
SER A 234
ASN A 236
LYS A 375
GLY A 377
SER A 378
 None
J01  A 600 (-3.4A)
None
J01  A 600 ( 4.4A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
 0.58A 3q07B-2xfsA:
22.8		 3q07B-2xfsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 GLN A 408
GLY A 381
ASP A 325
GLY A 316
SER A 206
 None
 1.13A 3sudB-2xfsA:
undetectable		 3sudB-2xfsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 GLN A 408
GLY A 381
ASP A 325
GLY A 316
SER A 206
 None
 1.24A 3sueD-2xfsA:
undetectable		 3sueD-2xfsA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 GLN A 213
ASP A 235
ASP A 211
GLU A 225
ASP A 240
 None
 1.26A 4dmgA-2xfsA:
undetectable		 4dmgA-2xfsA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 2xfs ORF12
(Streptomyces
clavuligerus) 		6 / 12 ALA A 173
LYS A 176
SER A 234
ASN A 236
LYS A 375
GLY A 377
 J01  A 600 ( 4.0A)
None
J01  A 600 (-3.4A)
None
J01  A 600 ( 4.4A)
J01  A 600 ( 3.8A)
 0.69A 4euzA-2xfsA:
21.5		 4euzA-2xfsA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 11 ILE A 420
TRP A 387
LEU A 362
GLY A 414
PHE A 416
 None
None
None
J01  A 600 ( 4.7A)
None
 1.28A 4fogA-2xfsA:
undetectable		 4fogA-2xfsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 PRO A 208
LEU A 207
GLY A 218
ASP A 217
THR A 219
 None
 1.42A 4mubA-2xfsA:
undetectable		 4mubA-2xfsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 2xfs ORF12
(Streptomyces
clavuligerus) 		4 / 5 ARG A 286
MET A 304
GLU A 277
LEU A 278
 None
 1.45A 4v2oA-2xfsA:
0.0
4v2oC-2xfsA:
0.0		 4v2oA-2xfsA:
12.43
4v2oC-2xfsA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 11 LEU A 207
GLY A 279
LEU A 278
GLU A 277
ASP A 240
 None
 1.25A 4wnuC-2xfsA:
undetectable		 4wnuC-2xfsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 LEU A 432
SER A 434
LEU A 399
SER A 163
ILE A 424
 None
 1.05A 4x1fA-2xfsA:
undetectable		 4x1fA-2xfsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 LEU A 432
SER A 434
LEU A 399
SER A 163
ILE A 424
 None
 0.99A 4x1gA-2xfsA:
undetectable		 4x1gA-2xfsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 LEU A 270
VAL A 275
GLY A 172
HIS A 320
ILE A 324
 None
 1.02A 4xdrA-2xfsA:
undetectable		 4xdrA-2xfsA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 9 GLU A 203
VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 1.38A 5ksgB-2xfsA:
0.4		 5ksgB-2xfsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 9 GLU A 203
VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 1.40A 5ksnB-2xfsA:
undetectable		 5ksnB-2xfsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 9 GLU A 203
VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 1.36A 5kt8B-2xfsA:
0.0		 5kt8B-2xfsA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 9 ILE A 420
PHE A 416
VAL A 147
GLU A 136
ASP A 133
 None
 1.41A 5lg3B-2xfsA:
undetectable		 5lg3B-2xfsA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		4 / 7 THR A 118
LEU A 117
THR A  68
VAL A  51
 None
 1.11A 5ov9A-2xfsA:
undetectable		 5ov9A-2xfsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 9 GLU A 203
VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 1.38A 5sxsB-2xfsA:
0.4		 5sxsB-2xfsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		4 / 8 VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 0.88A 5sxtA-2xfsA:
undetectable		 5sxtA-2xfsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 8 GLU A 203
VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 1.38A 5sxtB-2xfsA:
undetectable		 5sxtB-2xfsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 8 GLU A 203
VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 1.36A 5syjB-2xfsA:
undetectable		 5syjB-2xfsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 12 LEU A 340
VAL A 336
ALA A 257
ALA A 258
GLY A 259
 None
 1.18A 5tzoB-2xfsA:
undetectable		 5tzoB-2xfsA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2xfs ORF12
(Streptomyces
clavuligerus) 		3 / 3 ILE A 324
VAL A 319
PRO A 380
 None
 0.65A 5uunA-2xfsA:
undetectable		 5uunA-2xfsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 2xfs ORF12
(Streptomyces
clavuligerus) 		6 / 12 ALA A 173
SER A 234
ASN A 236
LYS A 375
GLY A 377
SER A 378
 J01  A 600 ( 4.0A)
J01  A 600 (-3.4A)
None
J01  A 600 ( 4.4A)
J01  A 600 ( 3.8A)
J01  A 600 (-3.4A)
 0.32A 6c79A-2xfsA:
23.0		 6c79A-2xfsA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 9 GLU A 203
VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 1.36A 6cdqA-2xfsA:
undetectable		 6cdqA-2xfsA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2xfs ORF12
(Streptomyces
clavuligerus) 		5 / 9 GLU A 203
VAL A 307
GLY A 218
LEU A 200
THR A 199
 None
 1.32A 6cdqB-2xfsA:
0.0		 6cdqB-2xfsA:
11.69