SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2xfx MHC CLASS 1
(Bos
taurus) 		4 / 8 TYR A 159
PHE A 156
ARG A  62
THR A  24
 None
 1.22A 1ea1A-2xfxA:
undetectable		 1ea1A-2xfxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2xfx MHC CLASS 1
(Bos
taurus) 		4 / 8 TYR A  59
ARG A  62
GLU A  63
TYR A 159
 None
 1.30A 1nx9A-2xfxA:
undetectable		 1nx9A-2xfxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2xfx MHC CLASS 1
(Bos
taurus) 		4 / 8 TYR A  59
ARG A  62
GLU A  63
TYR A 159
 None
 1.31A 1nx9B-2xfxA:
undetectable		 1nx9B-2xfxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2xfx MHC CLASS 1
(Bos
taurus) 		4 / 8 TYR A  59
ARG A  62
GLU A  63
TYR A 159
 None
 1.30A 1nx9C-2xfxA:
undetectable		 1nx9C-2xfxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2xfx MHC CLASS 1
(Bos
taurus) 		4 / 8 TYR A  59
ARG A  62
GLU A  63
TYR A 159
 None
 1.30A 1nx9D-2xfxA:
undetectable		 1nx9D-2xfxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 2xfx MHC CLASS 1
(Bos
taurus) 		3 / 3 TRP A 167
GLU A  63
TYR A  59
 None
 1.09A 2a3aA-2xfxA:
undetectable		 2a3aA-2xfxA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2xfx MHC CLASS 1
(Bos
taurus) 		4 / 8 HIS A   9
SER A  67
ASN A  70
ILE A  66
 None
 0.98A 2v57A-2xfxA:
undetectable		 2v57A-2xfxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2xfx MHC CLASS 1
(Bos
taurus) 		4 / 8 HIS A   9
SER A  67
ASN A  70
ILE A  66
 None
 0.98A 2v57C-2xfxA:
undetectable		 2v57C-2xfxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2xfx MHC CLASS 1
(Bos
taurus) 		3 / 3 SER A 236
ARG A 234
GLN A 242
 None
 0.95A 2xnrA-2xfxA:
undetectable		 2xnrA-2xfxA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2xfx MHC CLASS 1
(Bos
taurus) 		3 / 3 ASP A 129
THR A 163
GLU A 161
 None
 0.79A 2zifB-2xfxA:
undetectable		 2zifB-2xfxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2xfx MHC CLASS 1
(Bos
taurus) 		4 / 7 GLU A  19
LEU A  72
ARG A  75
ALA A  71
 None
 1.27A 3mbgA-2xfxA:
undetectable
3mbgB-2xfxA:
undetectable		 3mbgA-2xfxA:
23.97
3mbgB-2xfxA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2xfx MHC CLASS 1
(Bos
taurus) 		4 / 5 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.39A 6f6sA-2xfxA:
undetectable
6f6sB-2xfxA:
undetectable		 6f6sA-2xfxA:
15.88
6f6sB-2xfxA:
19.00