SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2xgg MICRONEME PROTEIN 2
(Toxoplasma
gondii) 		4 / 7 SER A  84
SER A  86
SER A 154
THR A 155
 None
 0.67A 2i91A-2xggA:
undetectable		 2i91A-2xggA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2xgg MICRONEME PROTEIN 2
(Toxoplasma
gondii) 		4 / 7 SER A  84
SER A  86
SER A 154
THR A 155
 None
 0.66A 2i91B-2xggA:
7.0		 2i91B-2xggA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2xgg MICRONEME PROTEIN 2
(Toxoplasma
gondii) 		5 / 12 MET A 186
ILE A 184
LEU A 214
VAL A 113
LEU A 106
 None
GOL  A1218 ( 4.7A)
None
None
None
 0.94A 3a51C-2xggA:
undetectable		 3a51C-2xggA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2xgg MICRONEME PROTEIN 2
(Toxoplasma
gondii) 		4 / 5 VAL A 117
LEU A  99
ILE A  81
LEU A  80
 None
 0.83A 4mghA-2xggA:
undetectable		 4mghA-2xggA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2xgg MICRONEME PROTEIN 2
(Toxoplasma
gondii) 		4 / 5 ARG A 173
ALA A 135
GLY A 109
PRO A 110
 None
 0.70A 4u9uA-2xggA:
3.7		 4u9uA-2xggA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2xgg MICRONEME PROTEIN 2
(Toxoplasma
gondii) 		4 / 5 ARG A 173
ALA A 135
GLY A 109
PRO A 110
 None
 0.72A 4u9uB-2xggA:
3.7		 4u9uB-2xggA:
17.89