SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HXB_A_ROCA100_4 (HIV-1 PROTEASE)	2xgw	PEROXIDE RESISTANCE PROTEIN (Streptococcus pyogenes)	4 / 4	GLY A 143 ASP A 140 GLY A 135 THR A 14	None	1.00A	1hxbB-2xgwA: undetectable	1hxbB-2xgwA: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DL9_B_V2HB602_0 (CYTOCHROME P450 2R1)	2xgw	PEROXIDE RESISTANCE PROTEIN (Streptococcus pyogenes)	5 / 12	VAL A 31 ALA A 30 ALA A 37 ILE A 86 THR A 139	None	1.28A	3dl9B-2xgwA: undetectable	3dl9B-2xgwA: 16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K4V_D_ROCD201_2 (HIV-1 PROTEASE)	2xgw	PEROXIDE RESISTANCE PROTEIN (Streptococcus pyogenes)	4 / 4	GLY A 143 ASP A 140 GLY A 135 THR A 14	None	0.99A	3k4vC-2xgwA: undetectable	3k4vC-2xgwA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SPK_A_TPVA100_2 (HIV-1 PROTEASE)	2xgw	PEROXIDE RESISTANCE PROTEIN (Streptococcus pyogenes)	4 / 7	LEU A 83 ALA A 35 GLY A 135 ILE A 138	None	0.80A	3spkB-2xgwA: undetectable	3spkB-2xgwA: 18.97

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HXB_A_ROCA100_4","HIV-1 PROTEASE;HIV-1 PROTEASE","2xgw","PEROXIDE RESISTANCE PROTEIN","Streptococcus pyogenes",4,"GLY A 143;ASP A 140;GLY A 135;THR A  14","None","1.00A","1hxbB-2xgwA:undetectable","1hxbB-2xgwA:21.03"],["3DL9_B_V2HB602_0","CYTOCHROME P450 2R1","2xgw","PEROXIDE RESISTANCE PROTEIN","Streptococcus pyogenes",5,"VAL A  31;ALA A  30;ALA A  37;ILE A  86;THR A 139","None","1.28A","3dl9B-2xgwA:undetectable","3dl9B-2xgwA:16.77"],["3K4V_D_ROCD201_2","HIV-1 PROTEASE;HIV-1 PROTEASE","2xgw","PEROXIDE RESISTANCE PROTEIN","Streptococcus pyogenes",4,"GLY A 143;ASP A 140;GLY A 135;THR A  14","None","0.99A","3k4vC-2xgwA:undetectable","3k4vC-2xgwA:20.92"],["3SPK_A_TPVA100_2","HIV-1 PROTEASE;HIV-1 PROTEASE","2xgw","PEROXIDE RESISTANCE PROTEIN","Streptococcus pyogenes",4,"LEU A  83;ALA A  35;GLY A 135;ILE A 138","None","0.80A","3spkB-2xgwA:undetectable","3spkB-2xgwA:18.97"]]