SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	209D_C_DVAC2_0 (N8-ACTINOMYCIN D)	2xgy	RELIK CAPSID N-TERMINAL DOMAIN (Oryctolagus cuniculus)	3 / 3	THR A 36 PRO A 34 THR A 38	None	0.76A	209dC-2xgyA: undetectable	209dC-2xgyA: 45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VDY_A_HCYA1384_1 (CORTICOSTEROID-BINDI NG GLOBULIN)	2xgy	RELIK CAPSID N-TERMINAL DOMAIN (Oryctolagus cuniculus)	5 / 12	VAL A 128 PHE A 47 ILE A 52 ASN A 53 PHE A 40	None None None GOL A1138 (-3.7A) None	1.33A	2vdyA-2xgyA: undetectable	2vdyA-2xgyA: 16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IJI_H_BEZH501_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN YIBF)	2xgy	RELIK CAPSID N-TERMINAL DOMAIN (Oryctolagus cuniculus)	4 / 7	ASN A 57 VAL A 128 TYR A 124 ARG A 103	GOL A1138 (-4.0A) None None GOL A1138 (-4.0A)	0.91A	4ijiH-2xgyA: undetectable	4ijiH-2xgyA: 25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UC1_B_486B801_1 (GLUCOCORTICOID RECEPTOR)	2xgy	RELIK CAPSID N-TERMINAL DOMAIN (Oryctolagus cuniculus)	3 / 3	TRP A 22 MET A 54 ASN A 57	None None GOL A1138 (-4.0A)	1.48A	5uc1A-2xgyA: undetectable	5uc1A-2xgyA: 23.24

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["209D_C_DVAC2_0","N8-ACTINOMYCIN D","2xgy","RELIK CAPSID N-TERMINAL DOMAIN","Oryctolagus cuniculus",3,"THR A  36;PRO A  34;THR A  38","None","0.76A","209dC-2xgyA:undetectable","209dC-2xgyA:45.45"],["2VDY_A_HCYA1384_1","CORTICOSTEROID-BINDING GLOBULIN","2xgy","RELIK CAPSID N-TERMINAL DOMAIN","Oryctolagus cuniculus",5,"VAL A 128;PHE A  47;ILE A  52;ASN A  53;PHE A  40","None;None;None;GOL A1138 (-3.7A);None","1.33A","2vdyA-2xgyA:undetectable","2vdyA-2xgyA:16.81"],["4IJI_H_BEZH501_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN YIBF","2xgy","RELIK CAPSID N-TERMINAL DOMAIN","Oryctolagus cuniculus",4,"ASN A  57;VAL A 128;TYR A 124;ARG A 103","GOL A1138 (-4.0A);None;None;GOL A1138 (-4.0A)","0.91A","4ijiH-2xgyA:undetectable","4ijiH-2xgyA:25.93"],["5UC1_B_486B801_1","GLUCOCORTICOID RECEPTOR;GLUCOCORTICOID RECEPTOR","2xgy","RELIK CAPSID N-TERMINAL DOMAIN","Oryctolagus cuniculus",3,"TRP A  22;MET A  54;ASN A  57","None;None;GOL A1138 (-4.0A)","1.48A","5uc1A-2xgyA:undetectable","5uc1A-2xgyA:23.24"]]