SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLN A  89
ILE A 265
HIS A 318
 None
 0.70A 1fm9A-2xh1A:
undetectable		 1fm9A-2xh1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLN A  89
ILE A 265
HIS A 318
 None
 0.73A 1k74A-2xh1A:
undetectable		 1k74A-2xh1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 370
PRO A 383
GLU A 371
PHE A 387
 None
 1.27A 1oniA-2xh1A:
undetectable
1oniC-2xh1A:
undetectable		 1oniA-2xh1A:
16.00
1oniC-2xh1A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A 233
ASP A 230
ASP A 231
HIS A  95
 PLP  A1427 (-4.9A)
PLP  A1427 (-2.8A)
None
None
 1.18A 1t03A-2xh1A:
2.7		 1t03A-2xh1A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A 420
ILE A 363
VAL A 366
ALA A 374
LEU A 417
 None
 1.17A 2m9qA-2xh1A:
undetectable		 2m9qA-2xh1A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.74A 2vcvA-2xh1A:
undetectable		 2vcvA-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.75A 2vcvB-2xh1A:
undetectable		 2vcvB-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.77A 2vcvG-2xh1A:
undetectable		 2vcvG-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.86A 2vcvK-2xh1A:
undetectable		 2vcvK-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.81A 2vcvL-2xh1A:
undetectable		 2vcvL-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE A 414
PRO A 350
LEU A 334
ALA A 337
 None
 0.75A 2vcvP-2xh1A:
undetectable		 2vcvP-2xh1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  11
GLY A 120
GLU A 126
ILE A 256
ALA A 258
 None
 1.32A 3aodA-2xh1A:
undetectable		 3aodA-2xh1A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 417
ILE A 363
SER A 424
LEU A 369
LEU A 398
 None
 1.13A 3k2hA-2xh1A:
undetectable		 3k2hA-2xh1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A  91
ARG A 257
HIS A  95
ASP A 259
ILE A 264
 None
 1.16A 3njzA-2xh1A:
undetectable		 3njzA-2xh1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 273
GLY A 272
GLY A 116
ILE A 264
SER A 266
 None
None
PLP  A1427 ( 3.8A)
None
None
 1.01A 3nk7B-2xh1A:
undetectable		 3nk7B-2xh1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A 142
GLU A 139
TYR A 388
 PLP  A1427 ( 3.6A)
None
None
 1.02A 3ug8A-2xh1A:
undetectable		 3ug8A-2xh1A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A 194
ASP A 231
VAL A 255
LEU A 247
ILE A 227
 None
 1.18A 3wsjA-2xh1A:
undetectable		 3wsjA-2xh1A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A  95
GLU A 229
ASN A 199
 None
 0.98A 4bupB-2xh1A:
undetectable		 4bupB-2xh1A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 421
GLN A 415
LEU A 417
LEU A 341
ILE A 333
 None
 1.07A 4g1bD-2xh1A:
undetectable		 4g1bD-2xh1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 11 PRO A 232
TYR A 195
ASP A 230
LEU A 146
LEU A 149
PHE A 125
 PLP  A1427 (-4.5A)
None
PLP  A1427 (-2.8A)
None
None
None
 1.31A 4odrA-2xh1A:
undetectable
4odrB-2xh1A:
undetectable		 4odrA-2xh1A:
14.72
4odrB-2xh1A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 425
SER A 424
ILE A 363
VAL A 366
 None
 0.88A 4tvtA-2xh1A:
undetectable		 4tvtA-2xh1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 230
ASN A 202
PHE A 261
 PLP  A1427 (-2.8A)
PLP  A1427 (-4.1A)
None
 0.90A 5jglB-2xh1A:
2.9		 5jglB-2xh1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A  99
THR A 275
ARG A 257
GLN A  91
 None
 1.30A 5tzoA-2xh1A:
undetectable		 5tzoA-2xh1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A  99
THR A 275
ARG A 257
GLN A  91
 None
 1.36A 5tzoB-2xh1A:
undetectable		 5tzoB-2xh1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A  99
THR A 275
ARG A 257
GLN A  91
 None
 1.30A 5tzoC-2xh1A:
undetectable		 5tzoC-2xh1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A  95
GLU A 229
ASN A 199
 None
 0.94A 5wbvA-2xh1A:
undetectable		 5wbvA-2xh1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A  95
GLU A 229
ASN A 199
 None
 0.93A 5wbvB-2xh1A:
undetectable		 5wbvB-2xh1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLN A 237
TYR A 234
ASN A 199
 None
 0.68A 6dwdC-2xh1A:
undetectable		 6dwdC-2xh1A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 321
VAL A 322
PHE A 235
ILE A 264
ILE A 265
 None
 1.30A 6gsdA-2xh1A:
3.8		 6gsdA-2xh1A:
10.00