SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xh6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 4 ARG A 185
GLY A 183
GLU A 181
SER A 154
 BOG  A1320 (-3.1A)
None
BOG  A1320 (-3.6A)
None
 1.10A 2xctS-2xh6A:
undetectable
2xctU-2xh6A:
undetectable		 2xctS-2xh6A:
18.12
2xctU-2xh6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 7 VAL A  81
TYR A 136
TYR A 156
ILE A 108
 None
 1.27A 2xz5B-2xh6A:
undetectable
2xz5E-2xh6A:
undetectable		 2xz5B-2xh6A:
20.25
2xz5E-2xh6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 7 ILE A 108
VAL A  81
TYR A 136
TYR A 156
 None
 1.29A 2xz5D-2xh6A:
undetectable
2xz5E-2xh6A:
undetectable		 2xz5D-2xh6A:
20.25
2xz5E-2xh6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 7 ALA A 302
TYR A 312
ILE A 258
HIS A 285
 None
 1.16A 2zm7A-2xh6A:
undetectable		 2zm7A-2xh6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 12 TYR A 251
ILE A 253
VAL A 287
PHE A 316
TYR A 296
 None
 1.44A 3a8iD-2xh6A:
undetectable		 3a8iD-2xh6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 5 SER A 154
ARG A 185
GLY A 183
GLU A 181
 None
BOG  A1320 (-3.1A)
None
BOG  A1320 (-3.6A)
 1.28A 3k9fA-2xh6A:
undetectable
3k9fB-2xh6A:
undetectable
3k9fC-2xh6A:
undetectable		 3k9fA-2xh6A:
21.33
3k9fB-2xh6A:
21.33
3k9fC-2xh6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 9 VAL A  81
TYR A 136
TYR A 156
ILE A  96
ILE A 108
 None
 1.28A 4afgA-2xh6A:
0.0
4afgB-2xh6A:
0.0		 4afgA-2xh6A:
21.43
4afgB-2xh6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 9 ILE A  96
ILE A 108
VAL A  81
TYR A 136
TYR A 156
 None
 1.34A 4afgA-2xh6A:
0.0
4afgE-2xh6A:
0.0		 4afgA-2xh6A:
21.43
4afgE-2xh6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 8 VAL A  81
TYR A 136
TYR A 156
ILE A  96
ILE A 108
 None
 1.27A 4afgD-2xh6A:
undetectable
4afgE-2xh6A:
undetectable		 4afgD-2xh6A:
21.43
4afgE-2xh6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_D_QMRD1214_1
(CAPITELLA TELETA
ACHBP)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 9 VAL A  81
TYR A 136
TYR A 156
ILE A  96
ILE A 108
 None
 1.30A 4afgC-2xh6A:
0.0
4afgD-2xh6A:
0.0		 4afgC-2xh6A:
21.43
4afgD-2xh6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_E_QMRE1214_1
(CAPITELLA TELETA
ACHBP)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 9 VAL A  81
TYR A 136
TYR A 156
ILE A  96
ILE A 108
 None
 1.33A 4afgB-2xh6A:
0.0
4afgC-2xh6A:
0.0		 4afgB-2xh6A:
21.43
4afgC-2xh6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 8 VAL A  81
TYR A 136
TYR A 156
ILE A 108
 None
 1.26A 4bqtC-2xh6A:
undetectable
4bqtD-2xh6A:
undetectable		 4bqtC-2xh6A:
20.25
4bqtD-2xh6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 5 SER A 154
ARG A 185
GLY A 183
GLU A 181
 None
BOG  A1320 (-3.1A)
None
BOG  A1320 (-3.6A)
 0.97A 5cdqA-2xh6A:
undetectable
5cdqB-2xh6A:
undetectable
5cdqC-2xh6A:
undetectable		 5cdqA-2xh6A:
20.41
5cdqB-2xh6A:
20.44
5cdqC-2xh6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 5 SER A 154
ARG A 185
GLY A 183
GLU A 181
 None
BOG  A1320 (-3.1A)
None
BOG  A1320 (-3.6A)
 0.96A 5cdqR-2xh6A:
undetectable
5cdqS-2xh6A:
undetectable
5cdqT-2xh6A:
undetectable		 5cdqR-2xh6A:
20.41
5cdqS-2xh6A:
20.44
5cdqT-2xh6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 12 ASP A 151
ILE A 142
ARG A 143
LEU A  41
GLY A 153
 None
 1.32A 5k7uA-2xh6A:
undetectable		 5k7uA-2xh6A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		3 / 3 SER A 145
SER A 150
ALA A 203
 None
 0.72A 6dwnC-2xh6A:
undetectable		 6dwnC-2xh6A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 8 ASP A  39
SER A 150
SER A  88
ASP A 260
 None
 1.18A 6fbnB-2xh6A:
undetectable		 6fbnB-2xh6A:
20.40