SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Thermotoga
maritima) 		3 / 3 ARG A 222
VAL A 101
THR A 110
 None
 0.86A 3cyxA-2xhcA:
undetectable		 3cyxA-2xhcA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Thermotoga
maritima) 		5 / 12 VAL A 342
PHE A 232
VAL A  39
LEU A 283
ILE A 277
 None
 1.26A 3elzC-2xhcA:
undetectable		 3elzC-2xhcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Thermotoga
maritima) 		5 / 12 PHE A 232
ILE A 277
VAL A 349
LEU A 329
ILE A 307
 None
 1.14A 3em0B-2xhcA:
undetectable		 3em0B-2xhcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Thermotoga
maritima) 		3 / 3 ARG A 209
GLU A 348
TYR A 286
 None
 0.80A 3k37B-2xhcA:
undetectable		 3k37B-2xhcA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Thermotoga
maritima) 		5 / 12 LEU A 344
VAL A 333
VAL A 305
GLY A 317
PRO A 341
 None
 1.19A 3mecA-2xhcA:
3.6		 3mecA-2xhcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Thermotoga
maritima) 		4 / 7 GLU A 189
VAL A 190
LEU A 196
TYR A 172
 None
 1.03A 3qeoB-2xhcA:
undetectable		 3qeoB-2xhcA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Thermotoga
maritima) 		5 / 12 GLY A  68
LEU A 280
ILE A 335
LEU A 344
HIS A 345
 None
 1.16A 4ze2A-2xhcA:
undetectable		 4ze2A-2xhcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Thermotoga
maritima) 		4 / 6 ILE A 144
PRO A 136
ILE A 151
VAL A 102
 None
 1.00A 4zj8A-2xhcA:
undetectable		 4zj8A-2xhcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Thermotoga
maritima) 		4 / 5 TYR A   6
ASN A 243
TYR A 247
PHE A 259
 None
 1.41A 6h3dA-2xhcA:
undetectable		 6h3dA-2xhcA:
23.58