SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 4 ALA A 245
GLN A 242
TYR A 246
LEU A 345
 None
 1.29A 1e6wC-2xheA:
0.9		 1e6wC-2xheA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 LYS A   4
GLU A  39
GLU A 136
GLU A 276
 None
 1.13A 1knyA-2xheA:
undetectable
1knyB-2xheA:
undetectable		 1knyA-2xheA:
16.80
1knyB-2xheA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 4 ASP A 402
HIS A 237
ARG A 405
GLU A 368
 None
 1.20A 1lqtA-2xheA:
undetectable		 1lqtA-2xheA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.96A 1rxcC-2xheA:
undetectable		 1rxcC-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.94A 1rxcD-2xheA:
undetectable		 1rxcD-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 1.04A 1rxcF-2xheA:
undetectable		 1rxcF-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 1.03A 1rxcL-2xheA:
undetectable		 1rxcL-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 HIS A 599
LEU A 225
ILE A 224
SER A 187
 None
 1.19A 1sbrA-2xheA:
undetectable
1sbrB-2xheA:
undetectable		 1sbrA-2xheA:
15.82
1sbrB-2xheA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 VAL A  83
THR A  76
TYR A  71
LEU A  99
 None
 0.82A 1z2bB-2xheA:
3.7		 1z2bB-2xheA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 ARG A 167
HIS A 599
ASN A 143
GLY A 147
 None
 0.87A 2f6dA-2xheA:
undetectable		 2f6dA-2xheA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xhe SYNTAXIN1
UNC18
(Monosiga
brevicollis) 		4 / 6 VAL A  54
VAL B 129
ILE B 135
ARG B 249
 None
 1.02A 2hyyA-2xheA:
undetectable		 2hyyA-2xheA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2xhe UNC18
(Monosiga
brevicollis) 		3 / 3 ASP A 427
ASN A 424
THR A 417
 None
 0.69A 2pymB-2xheA:
undetectable		 2pymB-2xheA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2xhe UNC18
(Monosiga
brevicollis) 		3 / 3 ASP A 427
ASN A 424
THR A 417
 None
 0.69A 2q63B-2xheA:
undetectable		 2q63B-2xheA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2xhe SYNTAXIN1
(Monosiga
brevicollis) 		5 / 12 SER B 257
VAL B 129
GLN B 243
ARG B 134
SER B 141
 None
 1.41A 2vdyB-2xheB:
undetectable		 2vdyB-2xheB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2xhe UNC18
(Monosiga
brevicollis) 		3 / 3 LEU A 491
TYR A 485
GLN A 490
 None
 0.67A 2wekA-2xheA:
3.0		 2wekA-2xheA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2xhe SYNTAXIN1
UNC18
(Monosiga
brevicollis) 		4 / 6 ASP B 132
ILE B 135
GLU A  55
TYR A  94
 None
 1.40A 2ya7C-2xheB:
undetectable		 2ya7C-2xheB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 ARG A  35
ASP A 254
ILE A 251
GLU A 606
 None
 1.27A 2ya7C-2xheA:
undetectable		 2ya7C-2xheA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2xhe SYNTAXIN1
(Monosiga
brevicollis) 		4 / 5 TYR B 154
MET B  94
THR B  93
LEU B  90
 None
 1.36A 3ag2J-2xheB:
undetectable		 3ag2J-2xheB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2xhe SYNTAXIN1
(Monosiga
brevicollis) 		4 / 5 TYR B 154
MET B  94
THR B  93
LEU B  90
 None
 1.38A 3ag4J-2xheB:
undetectable		 3ag4J-2xheB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 2xhe UNC18
(Monosiga
brevicollis) 		5 / 12 LEU A 422
LEU A 425
TYR A 440
ALA A 429
LEU A 404
 None
 1.26A 3gwuA-2xheA:
undetectable		 3gwuA-2xheA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 2xhe UNC18
(Monosiga
brevicollis) 		6 / 12 LEU A 422
LEU A 425
TYR A 440
ILE A 439
ALA A 429
LEU A 404
 None
 1.49A 3gwvA-2xheA:
undetectable		 3gwvA-2xheA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 1.01A 3kvvA-2xheA:
undetectable		 3kvvA-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.97A 3kvvB-2xheA:
undetectable		 3kvvB-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.95A 3kvvC-2xheA:
undetectable		 3kvvC-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.94A 3kvvD-2xheA:
undetectable		 3kvvD-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.99A 3kvvE-2xheA:
undetectable		 3kvvE-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 1.04A 3kvvF-2xheA:
undetectable		 3kvvF-2xheA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2xhe UNC18
(Monosiga
brevicollis) 		5 / 12 VAL A  83
LEU A 113
GLY A  69
ALA A  97
LEU A  99
 None
 1.05A 3nt1A-2xheA:
undetectable		 3nt1A-2xheA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2xhe UNC18
(Monosiga
brevicollis) 		5 / 12 VAL A  83
LEU A 113
GLY A  69
ALA A  97
LEU A  99
 None
 1.05A 3nt1B-2xheA:
undetectable		 3nt1B-2xheA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2xhe UNC18
(Monosiga
brevicollis) 		3 / 3 ALA A 498
VAL A 499
GLN A 199
 None
 0.62A 3of4B-2xheA:
undetectable		 3of4B-2xheA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2xhe UNC18
(Monosiga
brevicollis) 		3 / 3 HIS A 163
ARG A 166
GLU A  74
 None
 1.18A 3qf1A-2xheA:
undetectable		 3qf1A-2xheA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xhe UNC18
(Monosiga
brevicollis) 		3 / 3 PHE A 222
GLN A 197
PHE A 140
 None
 0.75A 3rv5A-2xheA:
undetectable		 3rv5A-2xheA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 2xhe UNC18
SYNTAXIN1
(Monosiga
brevicollis;
Monosiga
brevicollis) 		4 / 5 THR A  52
ILE B 135
PHE B  47
LEU A  64
 None
 1.44A 3tf1A-2xheA:
undetectable		 3tf1A-2xheA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 TRP A 281
LEU A 274
MET A 349
HIS A 346
 None
 1.46A 3zmdA-2xheA:
undetectable
3zmdB-2xheA:
undetectable		 3zmdA-2xheA:
16.73
3zmdB-2xheA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 1.00A 4e1vB-2xheA:
undetectable		 4e1vB-2xheA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.99A 4e1vC-2xheA:
undetectable		 4e1vC-2xheA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.99A 4e1vD-2xheA:
undetectable		 4e1vD-2xheA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.98A 4e1vF-2xheA:
undetectable		 4e1vF-2xheA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.87A 4e1vG-2xheA:
undetectable		 4e1vG-2xheA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 GLN A 199
ARG A 500
ILE A 211
VAL A 206
 None
 0.97A 4e1vH-2xheA:
undetectable		 4e1vH-2xheA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xhe UNC18
(Monosiga
brevicollis) 		5 / 12 LEU A 171
LEU A 168
LEU A 164
THR A 191
VAL A 575
 None
 1.22A 4f4dB-2xheA:
3.4		 4f4dB-2xheA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.97A 4feuB-2xheA:
undetectable		 4feuB-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.94A 4feuD-2xheA:
undetectable		 4feuD-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.90A 4feuF-2xheA:
undetectable		 4feuF-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.98A 4fevB-2xheA:
undetectable		 4fevB-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.91A 4fevD-2xheA:
undetectable		 4fevD-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.90A 4fevF-2xheA:
undetectable		 4fevF-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.95A 4fewB-2xheA:
undetectable		 4fewB-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.88A 4fewD-2xheA:
undetectable		 4fewD-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.89A 4fewF-2xheA:
undetectable		 4fewF-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.92A 4fexB-2xheA:
undetectable		 4fexB-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 ARG A 167
ASN A  79
GLU A  74
GLN A 150
 None
 1.21A 4g0vB-2xheA:
undetectable		 4g0vB-2xheA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.93A 4gkhB-2xheA:
undetectable		 4gkhB-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.97A 4gkhD-2xheA:
undetectable		 4gkhD-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.89A 4gkhF-2xheA:
undetectable		 4gkhF-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.90A 4gkhG-2xheA:
undetectable		 4gkhG-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 1.00A 4gkhJ-2xheA:
undetectable		 4gkhJ-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.91A 4gkhC-2xheA:
undetectable
4gkhK-2xheA:
undetectable		 4gkhC-2xheA:
16.92
4gkhK-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.88A 4gkiA-2xheA:
undetectable		 4gkiA-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.90A 4gkiC-2xheA:
undetectable		 4gkiC-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.89A 4gkiE-2xheA:
undetectable
4gkiG-2xheA:
undetectable		 4gkiE-2xheA:
16.92
4gkiG-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 8 VAL A 471
LEU A 472
ILE A 361
VAL A 392
 None
 0.92A 4ma7A-2xheA:
2.4		 4ma7A-2xheA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xhe UNC18
(Monosiga
brevicollis) 		5 / 10 VAL A  83
LEU A 113
GLY A  69
ALA A  97
LEU A  99
 None
 1.05A 4ph9A-2xheA:
undetectable		 4ph9A-2xheA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xhe UNC18
(Monosiga
brevicollis) 		5 / 10 VAL A  83
LEU A 113
GLY A  69
ALA A  97
LEU A  99
 None
 1.04A 4ph9B-2xheA:
undetectable		 4ph9B-2xheA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2xhe SYNTAXIN1
(Monosiga
brevicollis) 		4 / 5 GLN B 221
LEU B 222
SER B 225
ASP B  59
 None
 1.08A 4qtuD-2xheB:
undetectable		 4qtuD-2xheB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xhe UNC18
(Monosiga
brevicollis) 		5 / 9 VAL A  83
LEU A 113
GLY A  69
ALA A  97
LEU A  99
 None
 1.06A 4rs0A-2xheA:
undetectable		 4rs0A-2xheA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 2xhe SYNTAXIN1
(Monosiga
brevicollis) 		5 / 12 LEU B 229
ILE B  64
VAL B 150
PHE B 147
MET B 151
 None
 1.14A 4y0pA-2xheB:
undetectable		 4y0pA-2xheB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 5 SER A 158
SER A 156
SER A 157
SER A 154
 None
 1.44A 5hswA-2xheA:
undetectable		 5hswA-2xheA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2xhe UNC18
(Monosiga
brevicollis) 		3 / 3 ALA A 438
ASN A 441
LEU A 442
 None
 0.41A 5i1nC-2xheA:
undetectable		 5i1nC-2xheA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2xhe UNC18
(Monosiga
brevicollis) 		3 / 3 ALA A 438
ASN A 441
LEU A 442
 None
 0.46A 5i1pD-2xheA:
undetectable		 5i1pD-2xheA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xhe UNC18
(Monosiga
brevicollis) 		5 / 12 VAL A  83
LEU A 113
GLY A  69
ALA A  97
LEU A  99
 None
 1.14A 5jvzB-2xheA:
undetectable		 5jvzB-2xheA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 6 TYR A 241
ASP A 279
TRP A 281
TYR A 256
 None
 1.12A 5ov9A-2xheA:
1.6		 5ov9A-2xheA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2xhe UNC18
(Monosiga
brevicollis) 		4 / 7 TYR A 241
ASP A 279
TRP A 281
TYR A 256
 None
 1.18A 5ov9B-2xheA:
undetectable		 5ov9B-2xheA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2xhe SYNTAXIN1
UNC18
(Monosiga
brevicollis) 		4 / 8 PHE B  46
GLN B 139
MET B  43
THR A  52
 None
 1.46A 5u6nA-2xheB:
undetectable		 5u6nA-2xheB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xhe SYNTAXIN1
(Monosiga
brevicollis) 		4 / 5 TYR B 154
MET B  94
THR B  93
LEU B  90
 None
 1.41A 5wauJ-2xheB:
undetectable		 5wauJ-2xheB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xhe SYNTAXIN1
(Monosiga
brevicollis) 		4 / 5 TYR B 154
MET B  94
THR B  93
LEU B  90
 None
 1.38A 5z86J-2xheB:
undetectable		 5z86J-2xheB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2xhe UNC18
SYNTAXIN1
(Monosiga
brevicollis;
Monosiga
brevicollis) 		4 / 7 ARG A  90
THR A  91
PRO A  92
PRO B  39
 None
 1.15A 6a4iB-2xheA:
undetectable		 6a4iB-2xheA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2xhe UNC18
(Monosiga
brevicollis) 		6 / 12 VAL A  54
PHE A 100
ILE A 128
VAL A  10
VAL A  29
PHE A  72
 None
 1.50A 6ap6A-2xheA:
2.8		 6ap6A-2xheA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2xhe UNC18
(Monosiga
brevicollis) 		6 / 12 VAL A  54
PHE A 100
ILE A 128
VAL A  10
VAL A  29
PHE A  72
 None
 1.50A 6ap6B-2xheA:
undetectable		 6ap6B-2xheA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2xhe UNC18
SYNTAXIN1
(Monosiga
brevicollis;
Monosiga
brevicollis) 		4 / 6 ARG B 145
ILE A  46
MET A  43
ASP B 248
 None
 1.35A 6dhbA-2xheB:
undetectable		 6dhbA-2xheB:
16.35