SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xhf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xhf PEROXIREDOXIN 5
(Alvinella
pompejana) 		4 / 7 SER A 173
GLN A 190
ILE A 169
SER A 186
 None
 1.08A 2xz5A-2xhfA:
undetectable
2xz5B-2xhfA:
undetectable		 2xz5A-2xhfA:
22.12
2xz5B-2xhfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xhf PEROXIREDOXIN 5
(Alvinella
pompejana) 		4 / 8 SER A 173
GLN A 190
ILE A 169
SER A 186
 None
 1.09A 2xz5B-2xhfA:
undetectable
2xz5E-2xhfA:
undetectable		 2xz5B-2xhfA:
22.12
2xz5E-2xhfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2xhf PEROXIREDOXIN 5
(Alvinella
pompejana) 		3 / 3 SER A  91
PHE A  96
LYS A  95
 None
 1.00A 3u88A-2xhfA:
undetectable		 3u88A-2xhfA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2xhf PEROXIREDOXIN 5
(Alvinella
pompejana) 		5 / 11 TYR A 160
LEU A  90
CYH A 183
ILE A 104
ILE A  86
 None
 1.39A 4a7aA-2xhfA:
undetectable		 4a7aA-2xhfA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 2xhf PEROXIREDOXIN 5
(Alvinella
pompejana) 		5 / 10 VAL A  75
VAL A  79
SER A 148
ASN A 154
ASN A 110
 None
 1.24A 4ldoA-2xhfA:
undetectable		 4ldoA-2xhfA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2xhf PEROXIREDOXIN 5
(Alvinella
pompejana) 		4 / 6 PHE A  58
PRO A  59
ARG A  65
ILE A  60
 None
 1.36A 5ih0A-2xhfA:
undetectable		 5ih0A-2xhfA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2xhf PEROXIREDOXIN 5
(Alvinella
pompejana) 		5 / 12 VAL A  75
VAL A  79
SER A 148
ASN A 154
ASN A 110
 None
 1.23A 6h7mB-2xhfA:
undetectable		 6h7mB-2xhfA:
17.24