SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 4 ILE A 174
MET A  58
VAL A 302
GLY A 164
 None
 1.11A 1e06B-2xhgA:
undetectable		 1e06B-2xhgA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 SER A 322
HIS A 463
SER A 459
LYS A 326
 None
 1.15A 1eqbA-2xhgA:
undetectable
1eqbB-2xhgA:
undetectable		 1eqbA-2xhgA:
23.31
1eqbB-2xhgA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 SER A 322
HIS A 463
SER A 459
LYS A 326
 None
 1.15A 1eqbA-2xhgA:
undetectable
1eqbB-2xhgA:
undetectable		 1eqbA-2xhgA:
23.31
1eqbB-2xhgA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 SER A 322
HIS A 463
SER A 459
LYS A 326
 None
 1.14A 1eqbC-2xhgA:
undetectable
1eqbD-2xhgA:
undetectable		 1eqbC-2xhgA:
23.31
1eqbD-2xhgA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 SER A 322
HIS A 463
SER A 459
LYS A 326
 None
 1.15A 1eqbC-2xhgA:
undetectable
1eqbD-2xhgA:
undetectable		 1eqbC-2xhgA:
23.31
1eqbD-2xhgA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		3 / 4 LYS A 128
ALA A 143
MET A 119
 None
 0.97A 1hk3A-2xhgA:
undetectable		 1hk3A-2xhgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		5 / 12 ILE A  62
LEU A 161
ILE A 174
LEU A 176
PRO A 177
 None
 1.05A 1jolB-2xhgA:
undetectable		 1jolB-2xhgA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		5 / 12 ILE A  62
LEU A 161
ILE A 174
LEU A 176
PRO A 177
 None
 1.05A 1rx8A-2xhgA:
undetectable		 1rx8A-2xhgA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		3 / 3 LEU A 140
LEU A 131
SER A  95
 None
 0.68A 1tlmA-2xhgA:
undetectable		 1tlmA-2xhgA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.19A 1v55C-2xhgA:
undetectable
1v55N-2xhgA:
undetectable
1v55P-2xhgA:
undetectable		 1v55C-2xhgA:
19.86
1v55N-2xhgA:
20.56
1v55P-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 6 ASN A 412
LEU A 441
LEU A 424
ILE A 438
 None
 0.94A 1z95A-2xhgA:
undetectable		 1z95A-2xhgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		5 / 12 HIS A  65
ARG A 300
GLN A  10
ASP A  66
LEU A  68
 None
None
None
GOL  A1464 (-3.9A)
None
 1.36A 2a5hB-2xhgA:
0.0		 2a5hB-2xhgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		5 / 12 HIS A  65
ARG A 300
GLN A  10
ASP A  66
LEU A  68
 None
None
None
GOL  A1464 (-3.9A)
None
 1.35A 2a5hC-2xhgA:
undetectable		 2a5hC-2xhgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		5 / 12 HIS A  65
ARG A 300
GLN A  10
ASP A  66
LEU A  68
 None
None
None
GOL  A1464 (-3.9A)
None
 1.36A 2a5hD-2xhgA:
undetectable		 2a5hD-2xhgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		3 / 3 ASP A 181
THR A  20
PRO A  21
 None
 0.30A 2pynB-2xhgA:
undetectable		 2pynB-2xhgA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		3 / 3 ASP A 181
THR A  20
PRO A  21
 None
 0.36A 2q64B-2xhgA:
undetectable		 2q64B-2xhgA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		3 / 3 ASP A 181
THR A  20
PRO A  21
 None
 0.31A 2qakB-2xhgA:
undetectable		 2qakB-2xhgA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 6 LEU A 140
LEU A  43
ILE A  54
ARG A  45
 None
 0.95A 2rlfC-2xhgA:
undetectable
2rlfD-2xhgA:
undetectable		 2rlfC-2xhgA:
9.62
2rlfD-2xhgA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 SER A 322
HIS A 463
SER A 459
LYS A 326
 None
 1.15A 2vmyA-2xhgA:
undetectable
2vmyB-2xhgA:
undetectable		 2vmyA-2xhgA:
22.49
2vmyB-2xhgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.17A 2y69C-2xhgA:
undetectable
2y69N-2xhgA:
undetectable
2y69P-2xhgA:
undetectable		 2y69C-2xhgA:
19.86
2y69N-2xhgA:
20.56
2y69P-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.17A 3ablA-2xhgA:
undetectable
3ablC-2xhgA:
undetectable
3ablP-2xhgA:
undetectable		 3ablA-2xhgA:
20.56
3ablC-2xhgA:
19.86
3ablP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.20A 3abmA-2xhgA:
undetectable
3abmC-2xhgA:
undetectable
3abmP-2xhgA:
undetectable		 3abmA-2xhgA:
20.56
3abmC-2xhgA:
19.86
3abmP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.18A 3asnC-2xhgA:
undetectable
3asnN-2xhgA:
undetectable
3asnP-2xhgA:
undetectable		 3asnC-2xhgA:
19.86
3asnN-2xhgA:
20.56
3asnP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.19A 3asoA-2xhgA:
undetectable
3asoC-2xhgA:
undetectable
3asoP-2xhgA:
undetectable		 3asoA-2xhgA:
20.56
3asoC-2xhgA:
19.86
3asoP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.19A 3asoC-2xhgA:
undetectable
3asoN-2xhgA:
undetectable
3asoP-2xhgA:
undetectable		 3asoC-2xhgA:
19.86
3asoN-2xhgA:
20.56
3asoP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 LEU A 161
LEU A 140
SER A  40
THR A 112
 None
 1.05A 3lm8B-2xhgA:
undetectable
3lm8D-2xhgA:
undetectable		 3lm8B-2xhgA:
19.75
3lm8D-2xhgA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		3 / 3 ASP A 181
THR A  20
PRO A  21
 None
 0.39A 3tkgD-2xhgA:
undetectable		 3tkgD-2xhgA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.20A 3wg7C-2xhgA:
undetectable
3wg7N-2xhgA:
undetectable
3wg7P-2xhgA:
undetectable		 3wg7C-2xhgA:
19.86
3wg7N-2xhgA:
20.56
3wg7P-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.19A 3x2qA-2xhgA:
undetectable
3x2qC-2xhgA:
undetectable
3x2qP-2xhgA:
undetectable		 3x2qA-2xhgA:
20.56
3x2qC-2xhgA:
19.86
3x2qP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.17A 3x2qC-2xhgA:
undetectable
3x2qN-2xhgA:
undetectable
3x2qP-2xhgA:
undetectable		 3x2qC-2xhgA:
19.86
3x2qN-2xhgA:
20.56
3x2qP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		5 / 8 VAL A 365
LEU A 411
TYR A 428
TYR A 433
VAL A 224
 GOL  A1468 (-3.9A)
None
None
None
None
 1.35A 4ma7A-2xhgA:
undetectable		 4ma7A-2xhgA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 GLU A  47
TYR A 165
LEU A 161
PHE A  49
 None
 0.96A 4twdF-2xhgA:
1.1
4twdJ-2xhgA:
undetectable		 4twdF-2xhgA:
19.35
4twdJ-2xhgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		5 / 9 ALA A 266
LEU A 248
LEU A 263
ASN A 260
LEU A 247
 None
 1.48A 4x30A-2xhgA:
undetectable		 4x30A-2xhgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.23A 5b1aA-2xhgA:
undetectable
5b1aC-2xhgA:
undetectable
5b1aP-2xhgA:
undetectable		 5b1aA-2xhgA:
20.56
5b1aC-2xhgA:
19.86
5b1aP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.22A 5b3sA-2xhgA:
undetectable
5b3sC-2xhgA:
undetectable
5b3sP-2xhgA:
undetectable		 5b3sA-2xhgA:
20.56
5b3sC-2xhgA:
19.86
5b3sP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 5 SER A 427
GLY A 390
GLU A 109
ARG A 236
 None
 0.94A 5cdqA-2xhgA:
2.6
5cdqB-2xhgA:
undetectable
5cdqC-2xhgA:
2.6		 5cdqA-2xhgA:
22.06
5cdqB-2xhgA:
21.14
5cdqC-2xhgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 5 SER A 427
GLY A 390
GLU A 109
ARG A 236
 None
 1.01A 5cdqR-2xhgA:
2.6
5cdqS-2xhgA:
undetectable
5cdqT-2xhgA:
2.5		 5cdqR-2xhgA:
22.06
5cdqS-2xhgA:
21.14
5cdqT-2xhgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 6 PHE A 271
SER A 444
HIS A 448
LEU A 315
 None
 1.13A 5dzke-2xhgA:
undetectable
5dzks-2xhgA:
undetectable		 5dzke-2xhgA:
18.04
5dzks-2xhgA:
1.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		5 / 12 ALA A 278
LEU A 264
ILE A 259
PHE A 367
GLY A 415
 None
 1.19A 5fsaA-2xhgA:
undetectable		 5fsaA-2xhgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.17A 5iy5C-2xhgA:
undetectable
5iy5N-2xhgA:
undetectable
5iy5P-2xhgA:
undetectable		 5iy5C-2xhgA:
19.63
5iy5N-2xhgA:
20.56
5iy5P-2xhgA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.19A 5w97A-2xhgA:
undetectable
5w97C-2xhgA:
undetectable
5w97c-2xhgA:
undetectable		 5w97A-2xhgA:
20.56
5w97C-2xhgA:
19.86
5w97c-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.22A 5w97C-2xhgA:
undetectable
5w97a-2xhgA:
undetectable
5w97c-2xhgA:
undetectable		 5w97C-2xhgA:
19.86
5w97a-2xhgA:
20.56
5w97c-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.19A 5wauC-2xhgA:
undetectable
5waua-2xhgA:
undetectable
5wauc-2xhgA:
undetectable		 5wauC-2xhgA:
19.86
5waua-2xhgA:
20.56
5wauc-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.18A 5x1bA-2xhgA:
undetectable
5x1bC-2xhgA:
undetectable
5x1bP-2xhgA:
undetectable		 5x1bA-2xhgA:
20.56
5x1bC-2xhgA:
19.86
5x1bP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.17A 5x1fA-2xhgA:
undetectable
5x1fC-2xhgA:
undetectable
5x1fP-2xhgA:
undetectable		 5x1fA-2xhgA:
20.56
5x1fC-2xhgA:
19.86
5x1fP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 5 HIS A 116
ASP A 396
GLY A 394
ASN A 400
 None
 1.37A 5x7pB-2xhgA:
undetectable		 5x7pB-2xhgA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.20A 5xdqA-2xhgA:
undetectable
5xdqC-2xhgA:
undetectable
5xdqP-2xhgA:
undetectable		 5xdqA-2xhgA:
20.56
5xdqC-2xhgA:
19.86
5xdqP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.17A 5xdqC-2xhgA:
undetectable
5xdqN-2xhgA:
undetectable
5xdqP-2xhgA:
undetectable		 5xdqC-2xhgA:
19.86
5xdqN-2xhgA:
20.56
5xdqP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.18A 5xdxC-2xhgA:
undetectable
5xdxN-2xhgA:
undetectable
5xdxP-2xhgA:
undetectable		 5xdxC-2xhgA:
19.63
5xdxN-2xhgA:
20.56
5xdxP-2xhgA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.21A 5z84A-2xhgA:
undetectable
5z84C-2xhgA:
undetectable
5z84P-2xhgA:
undetectable		 5z84A-2xhgA:
20.56
5z84C-2xhgA:
19.86
5z84P-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.18A 5z84C-2xhgA:
undetectable
5z84N-2xhgA:
undetectable
5z84P-2xhgA:
undetectable		 5z84C-2xhgA:
19.86
5z84N-2xhgA:
20.56
5z84P-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.22A 5z85A-2xhgA:
undetectable
5z85C-2xhgA:
undetectable
5z85P-2xhgA:
undetectable		 5z85A-2xhgA:
20.56
5z85C-2xhgA:
19.86
5z85P-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.20A 5z85C-2xhgA:
undetectable
5z85N-2xhgA:
undetectable
5z85P-2xhgA:
undetectable		 5z85C-2xhgA:
19.86
5z85N-2xhgA:
20.56
5z85P-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.22A 5z86A-2xhgA:
undetectable
5z86C-2xhgA:
undetectable
5z86P-2xhgA:
undetectable		 5z86A-2xhgA:
20.56
5z86C-2xhgA:
19.86
5z86P-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.18A 5z86C-2xhgA:
undetectable
5z86N-2xhgA:
undetectable
5z86P-2xhgA:
undetectable		 5z86C-2xhgA:
19.86
5z86N-2xhgA:
20.56
5z86P-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.22A 5zcoA-2xhgA:
undetectable
5zcoC-2xhgA:
undetectable
5zcoP-2xhgA:
undetectable		 5zcoA-2xhgA:
20.56
5zcoC-2xhgA:
19.86
5zcoP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.20A 5zcoC-2xhgA:
undetectable
5zcoN-2xhgA:
undetectable
5zcoP-2xhgA:
undetectable		 5zcoC-2xhgA:
19.86
5zcoN-2xhgA:
20.56
5zcoP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.21A 5zcpA-2xhgA:
undetectable
5zcpC-2xhgA:
undetectable
5zcpP-2xhgA:
undetectable		 5zcpA-2xhgA:
20.56
5zcpC-2xhgA:
19.86
5zcpP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.21A 5zcpC-2xhgA:
undetectable
5zcpN-2xhgA:
undetectable
5zcpP-2xhgA:
undetectable		 5zcpC-2xhgA:
19.86
5zcpN-2xhgA:
20.56
5zcpP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.21A 5zcqA-2xhgA:
undetectable
5zcqC-2xhgA:
undetectable
5zcqP-2xhgA:
undetectable		 5zcqA-2xhgA:
20.56
5zcqC-2xhgA:
19.86
5zcqP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 LEU A 321
ALA A 266
ALA A 265
THR A 257
 None
 0.89A 6a7jA-2xhgA:
undetectable		 6a7jA-2xhgA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		5 / 12 GLN A  39
THR A 392
ASN A 412
ASN A 368
LEU A 370
 None
None
None
NA  A1469 ( 4.9A)
None
 1.49A 6exiC-2xhgA:
undetectable		 6exiC-2xhgA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 8 LEU A 370
HIS A 116
THR A 392
HIS A  36
 None
 1.16A 6nknC-2xhgA:
undetectable
6nknN-2xhgA:
undetectable
6nknP-2xhgA:
undetectable		 6nknC-2xhgA:
19.86
6nknN-2xhgA:
20.56
6nknP-2xhgA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xhg TYROCIDINE
SYNTHETASE A
(Brevibacillus
brevis) 		4 / 7 HIS A 116
THR A 392
HIS A  36
LEU A 370
 None
 1.14A 6nmfA-2xhgA:
undetectable
6nmfC-2xhgA:
undetectable
6nmfP-2xhgA:
undetectable		 6nmfA-2xhgA:
20.56
6nmfC-2xhgA:
19.86
6nmfP-2xhgA:
19.86