SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xhl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2xhl BOTULINUM NEUROTOXIN
B HEAVY CHAIN
(Clostridium
botulinum) 		5 / 12 TYR B 638
ALA B 782
ILE B 783
VAL B 636
LEU B 666
 None
 1.08A 1udtA-2xhlB:
undetectable		 1udtA-2xhlB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2xhl BOTULINUM NEUROTOXIN
B HEAVY CHAIN
(Clostridium
botulinum) 		3 / 3 ILE B 764
ASP B 767
PHE B 768
 None
 0.39A 1uwjB-2xhlB:
undetectable		 1uwjB-2xhlB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2xhl BOTULINUM NEUROTOXIN
B HEAVY CHAIN
(Clostridium
botulinum) 		4 / 5 TYR B 496
SER B 494
THR B 702
ASN B 705
 None
 1.30A 1yvpA-2xhlB:
2.2		 1yvpA-2xhlB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2xhl BOTULINUM NEUROTOXIN
B HEAVY CHAIN
(Clostridium
botulinum) 		5 / 11 TYR B 638
ALA B 782
ILE B 783
VAL B 636
LEU B 666
 None
 1.19A 2h42A-2xhlB:
undetectable		 2h42A-2xhlB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2xhl BOTULINUM NEUROTOXIN
B HEAVY CHAIN
(Clostridium
botulinum) 		5 / 12 TYR B 638
ALA B 782
ILE B 783
VAL B 636
LEU B 666
 None
 1.15A 2h42B-2xhlB:
undetectable		 2h42B-2xhlB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 2xhl BOTULINUM NEUROTOXIN
B HEAVY CHAIN
(Clostridium
botulinum) 		5 / 11 SER B 796
ILE B 665
SER B 664
ALA B 657
ILE B 635
 None
 1.03A 2nnhA-2xhlB:
undetectable		 2nnhA-2xhlB:
21.43