SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		3 / 3 THR A 970
PRO A 975
THR A 972
 None
 0.83A 1ovfB-2xhsA:
undetectable		 1ovfB-2xhsA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		4 / 5 LEU A 907
ASP A1000
MET A1020
LEU A 841
 None
 1.31A 2jfaA-2xhsA:
18.1		 2jfaA-2xhsA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		4 / 6 SER A 794
ARG A 798
PHE A 800
PHE A 853
 None
 1.25A 2qeiA-2xhsA:
undetectable		 2qeiA-2xhsA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 THR A 851
ALA A 848
LEU A 866
ILE A 949
LEU A 942
 None
 1.12A 2qxsA-2xhsA:
18.2		 2qxsA-2xhsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 THR A 851
ALA A 848
LEU A 866
ILE A 949
LEU A 942
 None
 1.09A 2qxsB-2xhsA:
17.7		 2qxsB-2xhsA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 7 PHE A 800
SER A 794
ILE A 797
THR A 851
GLY A 958
 None
 1.47A 2v0mB-2xhsA:
1.5		 2v0mB-2xhsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		4 / 7 GLY A 783
MET A 936
CYH A 935
PHE A 938
 None
 1.13A 3ko0R-2xhsA:
0.5
3ko0T-2xhsA:
undetectable		 3ko0R-2xhsA:
16.60
3ko0T-2xhsA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 HIS A 884
GLY A 783
ASP A 932
GLY A 931
TYR A 969
 None
 1.14A 4bz6C-2xhsA:
undetectable		 4bz6C-2xhsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		6 / 12 LEU A 841
VAL A 845
GLN A 862
MET A 863
GLN A 867
ALA A1023
 None
 0.63A 4ltwA-2xhsA:
19.9		 4ltwA-2xhsA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 LEU A1016
GLN A 862
MET A 863
GLN A 867
ALA A1023
 None
 0.94A 4ltwA-2xhsA:
19.9		 4ltwA-2xhsA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 HIS A 884
GLY A 783
ASP A 932
GLY A 931
TYR A 969
 None
 1.13A 4lxzA-2xhsA:
undetectable		 4lxzA-2xhsA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 HIS A 884
GLY A 783
ASP A 932
GLY A 931
TYR A 969
 None
 1.13A 4lxzC-2xhsA:
undetectable		 4lxzC-2xhsA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 HIS A 884
GLY A 783
ASP A 932
GLY A 931
TYR A 969
 None
 1.13A 4qa2A-2xhsA:
undetectable		 4qa2A-2xhsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 HIS A 884
GLY A 783
ASP A 932
GLY A 931
TYR A 969
 None
 1.12A 4qa2B-2xhsA:
undetectable		 4qa2B-2xhsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 ASP A 838
TRP A 870
LEU A 874
GLY A 998
LEU A1002
 None
 0.91A 4xi3B-2xhsA:
18.3		 4xi3B-2xhsA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 GLN A1014
ALA A1008
GLY A1009
ALA A1011
CYH A 834
 None
 1.36A 5l5zH-2xhsA:
undetectable
5l5zI-2xhsA:
undetectable		 5l5zH-2xhsA:
22.55
5l5zI-2xhsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		5 / 12 GLN A1014
ALA A1008
GLY A1009
ALA A1011
CYH A 834
 None
 1.34A 5l5zV-2xhsA:
undetectable
5l5zW-2xhsA:
undetectable		 5l5zV-2xhsA:
22.55
5l5zW-2xhsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		4 / 7 GLN A 844
LEU A 841
ASP A 838
LEU A 832
 None
 1.09A 5nwvA-2xhsA:
undetectable		 5nwvA-2xhsA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1
(Drosophila
melanogaster) 		4 / 7 VAL A 962
PRO A 790
LEU A 791
LEU A 787
 None
 0.79A 6aycA-2xhsA:
2.0		 6aycA-2xhsA:
14.52