SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xi7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 THR A  77
LEU A 112
LYS A 108
TYR A 109
 None
 1.06A 1gtiD-2xi7A:
undetectable		 1gtiD-2xi7A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 ILE A  91
ILE A 129
LEU A  45
ASN A  46
VAL A 154
 None
 1.01A 2nnhA-2xi7A:
undetectable		 2nnhA-2xi7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 10 ILE A  91
ILE A 129
LEU A  45
ASN A  46
VAL A 154
 None
 0.97A 2nnhB-2xi7A:
undetectable		 2nnhB-2xi7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 GLY A  38
ARG A  39
TYR A  93
 None
 0.81A 2opxA-2xi7A:
undetectable		 2opxA-2xi7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 6 LEU A  88
TYR A  83
ILE A  59
ILE A 122
 None
 1.00A 2q8hA-2xi7A:
undetectable		 2q8hA-2xi7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 5 GLN A 166
PHE A 162
LEU A  29
PHE A   9
 None
 1.45A 3ablC-2xi7A:
2.2
3ablJ-2xi7A:
undetectable		 3ablC-2xi7A:
20.39
3ablJ-2xi7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 11 LEU A  88
ASP A  79
ILE A  56
ILE A 124
ILE A  90
 None
MN  A1184 (-2.6A)
None
None
None
 1.10A 3s53B-2xi7A:
undetectable		 3s53B-2xi7A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 MET A  31
GLN A 160
TYR A   6
 XI7  A1186 ( 4.3A)
None
None
 1.07A 4udcA-2xi7A:
undetectable		 4udcA-2xi7A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 ASP A  79
TYR A 109
ASP A  92
ILE A  58
 MN  A1184 (-2.6A)
None
MN  A1184 ( 2.7A)
None
 1.04A 5cfsA-2xi7A:
undetectable		 5cfsA-2xi7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2xi7 RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 9 LEU A 120
ILE A  71
ILE A  90
GLU A 125
VAL A  87
 None
 1.40A 5igzA-2xi7A:
undetectable		 5igzA-2xi7A:
20.61