SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xij'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER A 183
VAL A 184
MET A 186
ASN A 257
PHE A 199
 None
 1.43A 1a27A-2xijA:
2.5		 1a27A-2xijA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 137
SER A 183
SER A 185
THR A 187
 5AD  A1746 ( 3.9A)
None
EDO  A1754 (-3.2A)
None
 0.69A 1dvxA-2xijA:
undetectable		 1dvxA-2xijA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 739
PHE A 643
PHE A 638
PHE A 722
 None
None
B12  A 800 ( 4.9A)
B12  A 800 (-4.0A)
 1.21A 1e71M-2xijA:
3.8		 1e71M-2xijA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 739
PHE A 643
PHE A 638
PHE A 722
 None
None
B12  A 800 ( 4.9A)
B12  A 800 (-4.0A)
 1.21A 1e72M-2xijA:
3.6		 1e72M-2xijA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY A 702
LEU A 713
VAL A 718
ASP A 709
ALA A 620
 B12  A 800 (-3.5A)
None
None
None
None
 1.49A 1fpqA-2xijA:
4.4		 1fpqA-2xijA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 MET A 322
ALA A 376
PHE A 315
ILE A 311
 None
 0.95A 1gm7A-2xijA:
undetectable
1gm7B-2xijA:
undetectable		 1gm7A-2xijA:
15.16
1gm7B-2xijA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A  84
THR A  92
TYR A 439
GLY A 325
ALA A 330
 None
 1.26A 1httD-2xijA:
7.2		 1httD-2xijA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 381
GLY A  94
THR A 382
PRO A 424
ALA A 422
 None
 1.10A 1nv8A-2xijA:
undetectable		 1nv8A-2xijA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 139
GLU A 117
TYR A 123
 None
EDO  A1753 (-2.8A)
None
 0.76A 1wsvA-2xijA:
undetectable		 1wsvA-2xijA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 158
GLY A 161
ASP A 139
ALA A 141
THR A 142
 None
 1.03A 2gluA-2xijA:
3.4		 2gluA-2xijA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 323
GLY A  94
PRO A  95
 None
 0.59A 2hreD-2xijA:
2.4		 2hreD-2xijA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 305
GLN A 338
ILE A 298
PHE A 301
 None
 1.07A 2jn3A-2xijA:
undetectable		 2jn3A-2xijA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 728
ALA A 732
ALA A 731
ALA A 600
ILE A 479
 None
None
B12  A 800 ( 4.4A)
None
None
 1.06A 3e00A-2xijA:
undetectable		 3e00A-2xijA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.18A 3eeyA-2xijA:
undetectable		 3eeyA-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.18A 3eeyB-2xijA:
undetectable		 3eeyB-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.18A 3eeyC-2xijA:
undetectable		 3eeyC-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.18A 3eeyD-2xijA:
undetectable		 3eeyD-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.17A 3eeyE-2xijA:
undetectable		 3eeyE-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.22A 3eeyH-2xijA:
undetectable		 3eeyH-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.19A 3eeyI-2xijA:
2.5		 3eeyI-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 435
ASP A 437
GLY A 380
LEU A 328
THR A  92
 None
 1.01A 3eeyJ-2xijA:
3.5		 3eeyJ-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 435
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.16A 3eeyJ-2xijA:
3.5		 3eeyJ-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 215
VAL A 184
LEU A 173
VAL A 136
ILE A 164
 None
 1.06A 3frqB-2xijA:
undetectable		 3frqB-2xijA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 158
GLY A 161
ASP A 139
ALA A 141
THR A 142
 None
 1.03A 3g88A-2xijA:
undetectable		 3g88A-2xijA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 158
GLY A 161
ASP A 139
ALA A 141
THR A 142
 None
 1.02A 3g88B-2xijA:
undetectable		 3g88B-2xijA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 158
GLY A 161
ASP A 139
ALA A 141
THR A 142
 None
 1.02A 3g89A-2xijA:
undetectable		 3g89A-2xijA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 158
GLY A 161
ASP A 139
ALA A 141
THR A 142
 None
 1.03A 3g89B-2xijA:
undetectable		 3g89B-2xijA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 158
GLY A 161
ASP A 139
ALA A 141
THR A 142
 None
 1.04A 3g8bA-2xijA:
undetectable		 3g8bA-2xijA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 158
GLY A 161
ASP A 139
ALA A 141
THR A 142
 None
 1.01A 3g8bB-2xijA:
undetectable		 3g8bB-2xijA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 717
LEU A 689
ARG A 694
LEU A 698
LEU A 685
 None
EDO  A1755 ( 4.8A)
None
None
None
 1.35A 3ndvA-2xijA:
undetectable
3ndvB-2xijA:
undetectable		 3ndvA-2xijA:
19.58
3ndvB-2xijA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 685
GLY A 717
LEU A 689
ARG A 694
LEU A 698
 None
None
EDO  A1755 ( 4.8A)
None
None
 1.37A 3ndvA-2xijA:
undetectable
3ndvB-2xijA:
undetectable		 3ndvA-2xijA:
19.58
3ndvB-2xijA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 717
LEU A 689
ARG A 694
LEU A 698
LEU A 685
 None
EDO  A1755 ( 4.8A)
None
None
None
 1.35A 3ndvC-2xijA:
undetectable
3ndvD-2xijA:
undetectable		 3ndvC-2xijA:
19.58
3ndvD-2xijA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 394
THR A 499
GLY A 725
PRO A 724
 None
None
B12  A 800 ( 4.4A)
B12  A 800 (-4.0A)
 0.88A 3ny4A-2xijA:
undetectable		 3ny4A-2xijA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ALA A 441
VAL A 438
ASP A 437
LEU A 434
 EDO  A1750 ( 4.6A)
None
None
None
 0.74A 3roxA-2xijA:
4.9		 3roxA-2xijA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 ALA A 441
ASP A 440
ASP A 437
GLY A 325
LEU A 275
ILE A 274
 EDO  A1750 ( 4.6A)
None
None
None
EDO  A1750 ( 4.5A)
EDO  A1750 (-3.9A)
 1.41A 3ttpA-2xijA:
undetectable		 3ttpA-2xijA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 ALA A 441
ASP A 440
ASP A 437
GLY A 325
LEU A 275
ILE A 274
 EDO  A1750 ( 4.6A)
None
None
None
EDO  A1750 ( 4.5A)
EDO  A1750 (-3.9A)
 1.44A 3ttpB-2xijA:
undetectable		 3ttpB-2xijA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 549
ASN A 219
ILE A 217
MET A 186
 None
 0.99A 3u5jA-2xijA:
undetectable		 3u5jA-2xijA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 196
MET A 188
ASP A 220
 None
 0.87A 3v5wA-2xijA:
undetectable		 3v5wA-2xijA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 563
ASP A 147
VAL A 162
ASP A 169
MET A 188
 None
 1.23A 4a81A-2xijA:
undetectable		 4a81A-2xijA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 563
THR A 566
ILE A 565
THR A 170
 None
 0.80A 4acaC-2xijA:
7.7		 4acaC-2xijA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLN A 476
GLU A 484
ILE A 468
VAL A 227
 B12  A 800 (-3.9A)
None
None
B12  A 800 (-4.5A)
 0.95A 4dx7B-2xijA:
undetectable		 4dx7B-2xijA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A 600
LEU A 641
PHE A 638
ILE A 634
ALA A 477
 None
None
B12  A 800 ( 4.9A)
B12  A 800 (-4.0A)
None
 1.06A 4j14A-2xijA:
undetectable		 4j14A-2xijA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 728
ALA A 732
ALA A 731
LEU A 641
ILE A 479
 None
None
B12  A 800 ( 4.4A)
None
None
 0.91A 4nqaH-2xijA:
undetectable		 4nqaH-2xijA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 THR A 202
ARG A 559
GLU A 168
VAL A 201
 None
 1.39A 4odoC-2xijA:
undetectable		 4odoC-2xijA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 173
ASN A 120
MET A 186
LEU A 179
 None
 1.16A 4okxA-2xijA:
undetectable		 4okxA-2xijA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASN A 365
MET A 375
ILE A 486
VAL A 485
 None
 0.96A 4olmA-2xijA:
undetectable		 4olmA-2xijA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 435
ASP A 437
ASN A 436
LEU A 328
THR A  92
 None
 1.23A 4pooA-2xijA:
undetectable		 4pooA-2xijA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLY A 648
PRO A 649
ALA A 578
 None
 0.51A 4qn9B-2xijA:
undetectable		 4qn9B-2xijA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 382
GLY A 380
ALA A 377
ILE A 311
 None
 0.87A 4txnA-2xijA:
3.4		 4txnA-2xijA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 382
GLY A 380
ALA A 377
ILE A 311
 None
 0.85A 4txnB-2xijA:
undetectable		 4txnB-2xijA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 382
GLY A 380
ALA A 377
ILE A 311
 None
 0.89A 4txnC-2xijA:
undetectable		 4txnC-2xijA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 382
GLY A 380
ALA A 377
ILE A 311
 None
 0.87A 4txnD-2xijA:
2.9		 4txnD-2xijA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 405
LEU A 385
GLY A 355
LEU A 358
PRO A 397
 None
None
B12  A 800 ( 4.4A)
None
None
 0.98A 4xi3B-2xijA:
undetectable		 4xi3B-2xijA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A 123
VAL A 116
ILE A 164
LEU A 179
 None
EDO  A1753 ( 4.7A)
None
None
 1.08A 4xo7B-2xijA:
6.0		 4xo7B-2xijA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 613
ASP A 665
VAL A 645
ASP A 646
 None
 1.23A 4xqeA-2xijA:
4.5		 4xqeA-2xijA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 613
ASP A 665
VAL A 645
ASP A 646
 None
 1.24A 4xqeB-2xijA:
undetectable		 4xqeB-2xijA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASN A 229
VAL A 227
TYR A 231
ILE A 242
GLN A 293
 None
B12  A 800 (-4.5A)
None
None
None
 1.44A 4xucA-2xijA:
3.9		 4xucA-2xijA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A  75
ARG A  76
HIS A  40
 None
 1.19A 4zbrA-2xijA:
0.7		 4zbrA-2xijA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 468
ILE A 221
ASN A 189
ARG A 228
LEU A 650
 None
None
None
B12  A 800 (-3.8A)
None
 1.08A 5fa8A-2xijA:
2.3		 5fa8A-2xijA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PRO A 339
LEU A 305
SER A 342
 None
 0.84A 5fsaB-2xijA:
undetectable		 5fsaB-2xijA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A  74
TYR A  73
TYR A 429
 None
 0.71A 5lakA-2xijA:
undetectable
5lakI-2xijA:
undetectable		 5lakA-2xijA:
17.52
5lakI-2xijA:
1.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A  74
TYR A  73
TYR A 429
 None
 0.73A 5lakC-2xijA:
undetectable
5lakJ-2xijA:
undetectable		 5lakC-2xijA:
17.52
5lakJ-2xijA:
1.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 221
GLY A 190
HIS A 143
VAL A 195
TYR A 287
 None
None
B12  A 800 (-4.2A)
None
None
 1.27A 5n0xB-2xijA:
2.7		 5n0xB-2xijA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 CYH A 351
ALA A 349
THR A 435
ILE A 311
ALA A 377
 None
 1.06A 5xiwD-2xijA:
4.5		 5xiwD-2xijA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 MET A 266
ILE A 446
ALA A 442
LEU A 277
ALA A 273
 None
 1.40A 5zjiB-2xijA:
undetectable		 5zjiB-2xijA:
8.25