SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 7 LYS A  49
ILE A  93
ARG A 139
LEU A 147
 None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
 0.73A 1iepB-2xikA:
19.0		 1iepB-2xikA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 4 THR A  79
GLY A 101
ASP A 105
ALA A 144
 J60  A1294 ( 4.2A)
J60  A1294 ( 3.8A)
J60  A1294 (-3.2A)
None
 1.24A 1sg9A-2xikA:
undetectable		 1sg9A-2xikA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A  70
LEU A 131
HIS A 138
 J60  A1294 (-3.3A)
None
None
None
None
 0.40A 1uwhA-2xikA:
16.8		 1uwhA-2xikA:
29.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
 0.52A 1uwjA-2xikA:
7.8		 1uwjA-2xikA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
 0.51A 1uwjB-2xikA:
7.8		 1uwjB-2xikA:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 4 LEU A 201
PRO A 242
ILE A 270
LEU A 264
 None
None
EDO  A1293 (-4.7A)
None
 1.07A 1ya4C-2xikA:
undetectable		 1ya4C-2xikA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 11 GLY A  27
VAL A  34
ALA A  47
TYR A  97
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
 0.64A 2evaA-2xikA:
19.6		 2evaA-2xikA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
VAL A  34
ALA A  47
ASP A 140
LYS A 142
ALA A 144
ASN A 145
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 ( 4.6A)
 0.63A 2fumA-2xikA:
22.0		 2fumA-2xikA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
VAL A  34
ALA A  47
MET A  95
TYR A  97
LYS A 142
ASN A 145
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
None
J60  A1294 ( 4.6A)
 0.68A 2fumB-2xikA:
22.0		 2fumB-2xikA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 GLY A  27
VAL A  34
ALA A  47
MET A  95
TYR A  97
ASN A 145
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
 0.69A 2fumC-2xikA:
20.8		 2fumC-2xikA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.63A 2gqgA-2xikA:
21.0		 2gqgA-2xikA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.55A 2gqgB-2xikA:
28.0		 2gqgB-2xikA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 2hyyA-2xikA:
19.1		 2hyyA-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.78A 2hyyB-2xikA:
19.0		 2hyyB-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.92A 2hyyD-2xikA:
18.9		 2hyyD-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 2oiqA-2xikA:
19.6		 2oiqA-2xikA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
ALA A 157
ASP A 158
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.86A 2pl0A-2xikA:
19.9		 2pl0A-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.94A 2pl0A-2xikA:
19.9		 2pl0A-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.73A 2y6oA-2xikA:
20.4		 2y6oA-2xikA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 ALA A  47
GLU A  66
VAL A  69
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.79A 3cs9A-2xikA:
18.8		 3cs9A-2xikA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
VAL A  69
GLY A 101
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.64A 3cs9B-2xikA:
19.7		 3cs9B-2xikA:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
GLY A  32
VAL A  34
ALA A  47
LYS A  49
MET A  95
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
None
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
 0.71A 3eygA-2xikA:
20.9		 3eygA-2xikA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 GLY A  27
GLY A  32
VAL A  34
ALA A  47
MET A  95
SER A 102
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.1A)
None
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.74A 3eygA-2xikA:
20.9		 3eygA-2xikA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 GLY A  27
GLY A  32
VAL A  34
ALA A  47
LYS A  49
MET A  95
TYR A  97
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
None
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
 0.89A 3fupA-2xikA:
27.6		 3fupA-2xikA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 GLY A  27
GLY A  32
VAL A  34
ALA A  47
MET A  95
TYR A  97
SER A 102
LEU A 147
ASP A 158
 J60  A1294 ( 4.1A)
None
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.96A 3fupA-2xikA:
27.6		 3fupA-2xikA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
ILE A  93
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.55A 3g5dA-2xikA:
21.0		 3g5dA-2xikA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
ILE A  93
TYR A  97
GLY A 101
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.50A 3g5dA-2xikA:
21.0		 3g5dA-2xikA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.74A 3g5dB-2xikA:
21.0		 3g5dB-2xikA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 5 LYS A  49
VAL A  69
ILE A  93
TYR A  97
 None
None
None
J60  A1294 (-4.5A)
 1.08A 3gvuA-2xikA:
19.2		 3gvuA-2xikA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.73A 3k5vA-2xikA:
23.7		 3k5vA-2xikA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.73A 3k5vB-2xikA:
18.4		 3k5vB-2xikA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		3 / 3 ALA A 118
ARG A 122
LYS A 126
 None
None
EDO  A1293 (-4.2A)
 0.60A 3kp3B-2xikA:
undetectable		 3kp3B-2xikA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		3 / 3 ALA A 118
ARG A 122
LYS A 126
 None
None
EDO  A1293 (-4.2A)
 0.62A 3kp5B-2xikA:
undetectable		 3kp5B-2xikA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
VAL A  34
ALA A  47
LYS A  49
MET A  95
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.89A 3lxkA-2xikA:
27.4		 3lxkA-2xikA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
VAL A  34
ALA A  47
MET A  95
TYR A  97
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 1.01A 3lxkA-2xikA:
27.4		 3lxkA-2xikA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 GLY A  27
VAL A  34
ALA A  47
LYS A  49
TYR A  97
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
 0.67A 3lxnA-2xikA:
27.8		 3lxnA-2xikA:
29.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
VAL A  69
ILE A  93
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.92A 3oezB-2xikA:
19.7		 3oezB-2xikA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A 157
THR A 204
LEU A 208
ILE A 124
THR A  79
 J60  A1294 ( 4.2A)
None
None
None
J60  A1294 ( 4.2A)
 1.17A 3qfxA-2xikA:
undetectable		 3qfxA-2xikA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A 157
THR A 204
LEU A 208
ILE A 124
THR A  79
 J60  A1294 ( 4.2A)
None
None
None
J60  A1294 ( 4.2A)
 1.16A 3qfxB-2xikA:
undetectable		 3qfxB-2xikA:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.69A 3qlgA-2xikA:
19.9		 3qlgA-2xikA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.60A 3qlgB-2xikA:
20.6		 3qlgB-2xikA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
TYR A  97
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
None
None
J60  A1294 ( 4.2A)
 0.86A 3rgfA-2xikA:
18.4		 3rgfA-2xikA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
 0.50A 3wzdA-2xikA:
18.7		 3wzdA-2xikA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
None
None
 0.51A 3wzeA-2xikA:
18.5		 3wzeA-2xikA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ARG A 139
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.71A 3zosA-2xikA:
17.8		 3zosA-2xikA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ARG A 139
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.76A 3zosB-2xikA:
17.9		 3zosB-2xikA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
LEU A 147
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.55A 4agcA-2xikA:
17.8		 4agcA-2xikA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
None
None
 0.56A 4asdA-2xikA:
23.6		 4asdA-2xikA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A  70
ILE A  93
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.67A 4c8bA-2xikA:
17.9		 4c8bA-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
LEU A  70
ILE A  93
HIS A 138
LEU A 147
 J60  A1294 (-3.3A)
None
None
None
None
None
J60  A1294 (-4.8A)
 0.91A 4c8bA-2xikA:
17.9		 4c8bA-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A  70
ILE A  78
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.60A 4c8bB-2xikA:
17.9		 4c8bB-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
LEU A  70
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.81A 4c8bB-2xikA:
17.9		 4c8bB-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 11 GLY A  27
GLY A  29
VAL A  34
ALA A  47
TYR A  97
GLY A 101
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.5A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
 0.90A 4ckiA-2xikA:
22.9		 4ckiA-2xikA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
ASP A 140
LYS A 142
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.56A 4i41A-2xikA:
29.0		 4i41A-2xikA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 10 ALA A 157
THR A 204
LEU A 208
ILE A 124
THR A  79
 J60  A1294 ( 4.2A)
None
None
None
J60  A1294 ( 4.2A)
 1.05A 4km0A-2xikA:
undetectable		 4km0A-2xikA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A 157
THR A 204
LEU A 208
ILE A 124
THR A  79
 J60  A1294 ( 4.2A)
None
None
None
J60  A1294 ( 4.2A)
 1.03A 4km0B-2xikA:
undetectable		 4km0B-2xikA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 10 ALA A  47
MET A  95
LEU A  98
GLY A 101
LEU A 147
 J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.6A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.40A 4ks8A-2xikA:
38.7		 4ks8A-2xikA:
38.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 7 VAL A  34
ALA A  47
MET A  95
LEU A 147
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.39A 4l9iA-2xikA:
24.9		 4l9iA-2xikA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.6A)
 0.78A 4mxoA-2xikA:
21.0		 4mxoA-2xikA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.80A 4mxoB-2xikA:
21.1		 4mxoB-2xikA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
ILE A  93
TYR A  97
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.76A 4mxoB-2xikA:
21.1		 4mxoB-2xikA:
29.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		10 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
MET A  95
TYR A  97
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.83A 4mxyA-2xikA:
20.3		 4mxyA-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 ALA A  47
LYS A  49
MET A  95
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.64A 4mxyB-2xikA:
20.5		 4mxyB-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.71A 4mxyB-2xikA:
20.5		 4mxyB-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		10 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
MET A  95
TYR A  97
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.83A 4mxzA-2xikA:
20.3		 4mxzA-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 ALA A  47
LYS A  49
MET A  95
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.64A 4mxzB-2xikA:
20.5		 4mxzB-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.71A 4mxzB-2xikA:
20.5		 4mxzB-2xikA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 8 GLY A  29
VAL A  34
ALA A  47
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.5A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.61A 4ogrA-2xikA:
30.8		 4ogrA-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 7 GLY A  27
ALA A  47
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.91A 4ogrE-2xikA:
29.5		 4ogrE-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 9 GLY A  29
VAL A  34
ALA A  47
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.5A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.62A 4ogrI-2xikA:
21.7		 4ogrI-2xikA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 ALA A  47
LYS A  49
GLU A  66
THR A  79
ILE A  93
TYR A  97
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 4.2A)
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.62A 4qmnA-2xikA:
35.8		 4qmnA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
ILE A  93
MET A  95
LEU A 147
ALA A 157
LYS A 288
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
None
 1.40A 4qmnA-2xikA:
35.8		 4qmnA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 ALA A  47
LYS A  49
THR A  79
ILE A  93
MET A  95
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
J60  A1294 ( 4.2A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.65A 4qmnA-2xikA:
35.8		 4qmnA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 11 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
LEU A  98
LEU A 147
ASP A 158
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.6A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.63A 4qmsA-2xikA:
35.8		 4qmsA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 11 ALA A  47
LYS A  49
ILE A  93
MET A  95
TYR A  97
LEU A  98
LEU A 147
ASP A 158
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.6A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.69A 4qmsA-2xikA:
35.8		 4qmsA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		10 / 12 GLY A  27
VAL A  34
ALA A  47
THR A  79
MET A  95
TYR A  97
LEU A  98
GLY A  99
LEU A 147
TYR A 287
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 4.2A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.6A)
J60  A1294 ( 3.7A)
J60  A1294 (-4.8A)
None
 0.55A 4qmzA-2xikA:
35.7		 4qmzA-2xikA:
84.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A 131
ARG A 139
ALA A 157
 J60  A1294 (-3.3A)
None
None
TPO  A 174 ( 2.9A)
J60  A1294 ( 4.2A)
 0.85A 4qrcA-2xikA:
18.7		 4qrcA-2xikA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLY A 101
ASN A 145
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.71A 4twpA-2xikA:
21.6		 4twpA-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLY A 101
ASN A 145
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.76A 4twpB-2xikA:
21.4		 4twpB-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 6 VAL A  34
LYS A  49
ARG A 139
ILE A  78
 J60  A1294 ( 4.9A)
None
TPO  A 174 ( 2.9A)
None
 0.73A 4tyjA-2xikA:
19.4		 4tyjA-2xikA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 11 VAL A  34
ALA A  47
TYR A  97
GLY A 101
ASN A 145
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.49A 4u5jA-2xikA:
21.1		 4u5jA-2xikA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
LEU A 131
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.56A 4uxqA-2xikA:
19.0		 4uxqA-2xikA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.60A 4v01A-2xikA:
19.3		 4v01A-2xikA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.55A 4v01B-2xikA:
19.5		 4v01B-2xikA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.63A 4v04A-2xikA:
18.5		 4v04A-2xikA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.61A 4v04B-2xikA:
18.6		 4v04B-2xikA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLY A 101
ASN A 145
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.98A 4wa9B-2xikA:
20.5		 4wa9B-2xikA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		3 / 3 ASP A 193
ARG A 258
PRO A 255
 None
 1.00A 4wanC-2xikA:
undetectable		 4wanC-2xikA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 LEU A 201
LEU A 208
THR A 277
VAL A 146
ALA A 103
 None
 1.11A 4x1kD-2xikA:
undetectable		 4x1kD-2xikA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.55A 4xliA-2xikA:
21.3		 4xliA-2xikA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.62A 4xliB-2xikA:
20.9		 4xliB-2xikA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 7 ILE A 117
LEU A 121
TYR A 273
LYS A 244
 None
 0.89A 4z69A-2xikA:
undetectable		 4z69A-2xikA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.77A 5bvwA-2xikA:
17.9		 5bvwA-2xikA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 9 ILE A 206
GLY A 202
LEU A 251
TRP A 199
ASN A 215
 None
 1.42A 5fhzB-2xikA:
undetectable		 5fhzB-2xikA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.73A 5i9xA-2xikA:
24.9		 5i9xA-2xikA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 8 LEU A 121
ILE A 117
ALA A 209
PRO A 259
 None
 1.03A 5m0oC-2xikA:
undetectable		 5m0oC-2xikA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 8 ALA A  47
GLU A  66
LEU A 147
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.51A 5owrA-2xikA:
23.0		 5owrA-2xikA:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 ALA A  47
GLU A  66
TYR A  97
GLY A 101
ASP A 105
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-3.2A)
J60  A1294 ( 4.6A)
 0.63A 5vc3A-2xikA:
20.4		 5vc3A-2xikA:
30.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		3 / 3 THR A 277
THR A 119
ARG A 122
 None
 0.88A 5wm2A-2xikA:
undetectable		 5wm2A-2xikA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.62A 5y80A-2xikA:
25.1		 5y80A-2xikA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 GLY A  27
ALA A  47
GLU A  66
TYR A  97
GLY A 101
ALA A 157
 J60  A1294 ( 4.1A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.77A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
TYR A  97
GLY A 101
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.57A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		3 / 3 LYS A  49
LEU A 147
ASP A 158
 None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.69A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		3 / 3 TYR A  97
LEU A 147
ASP A 158
 J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.70A 5zv2B-2xikA:
19.0		 5zv2B-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 5 VAL A 247
LEU A 121
VAL A 146
LEU A 128
 None
 0.83A 6bqgA-2xikA:
2.4		 6bqgA-2xikA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.69A 6bsdA-2xikA:
17.7		 6bsdA-2xikA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 6hd4A-2xikA:
18.3		 6hd4A-2xikA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.79A 6hd4B-2xikA:
18.3		 6hd4B-2xikA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 6hd6A-2xikA:
23.6		 6hd6A-2xikA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 7 ILE A  93
GLY A 101
ARG A 139
ALA A 157
 None
J60  A1294 ( 3.8A)
TPO  A 174 ( 2.9A)
J60  A1294 ( 4.2A)
 0.64A 6hd6B-2xikA:
18.3		 6hd6B-2xikA:
15.05