SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 12 ASP A  34
VAL A  35
GLY A  20
ILE A  21
PRO A 224
 None
 0.99A 1c6zA-2xioA:
undetectable		 1c6zA-2xioA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 11 ASP A  34
VAL A  35
GLY A  20
ILE A  21
PRO A 224
 None
 0.88A 1hxwB-2xioA:
undetectable		 1hxwB-2xioA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 4 HIS A 174
VAL A 172
THR A  73
LEU A 144
 EDO  A1299 (-4.1A)
None
None
None
 1.27A 1oq5A-2xioA:
undetectable		 1oq5A-2xioA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 175
ASP A 116
 None
None
EDO  A1299 (-3.3A)
None
 1.21A 1p7lC-2xioA:
undetectable		 1p7lC-2xioA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 175
ASP A 116
 None
None
EDO  A1299 (-3.3A)
None
 1.22A 1p7lD-2xioA:
undetectable		 1p7lD-2xioA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 175
ASP A 116
 None
None
EDO  A1299 (-3.3A)
None
 1.21A 1rg9C-2xioA:
undetectable		 1rg9C-2xioA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 11 SER A 214
VAL A 273
ALA A 272
LEU A 281
PHE A 195
 None
 1.12A 1uduA-2xioA:
undetectable		 1uduA-2xioA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 9 PHE A 157
VAL A 173
LEU A 191
PHE A 132
SER A 139
 None
 1.22A 1wrkA-2xioA:
undetectable
1wrkB-2xioA:
undetectable		 1wrkA-2xioA:
16.84
1wrkB-2xioA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.98A 2obvA-2xioA:
undetectable		 2obvA-2xioA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.98A 2p02A-2xioA:
undetectable		 2p02A-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 11 ASP A  34
VAL A  35
GLY A  20
ILE A  21
PRO A 224
 None
 1.03A 2qhcA-2xioA:
undetectable		 2qhcA-2xioA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		6 / 12 ASP A   8
GLY A  10
ASP A 222
ILE A 266
GLY A 194
ILE A 263
 None
None
EDO  A1299 (-2.9A)
None
None
None
 1.18A 2rkfB-2xioA:
undetectable		 2rkfB-2xioA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		6 / 12 ASP A   8
GLY A  10
ASP A 222
ILE A 266
GLY A 194
ILE A 263
 None
None
EDO  A1299 (-2.9A)
None
None
None
 1.22A 2rkgA-2xioA:
undetectable		 2rkgA-2xioA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 10 GLY A  51
ILE A  11
ASN A  12
LEU A  63
PHE A  70
 None
 1.18A 3ay0B-2xioA:
undetectable		 3ay0B-2xioA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 5 LEU A  93
GLN A 141
LEU A 138
GLU A 137
 None
 1.12A 3h5gA-2xioA:
undetectable
3h5gB-2xioA:
undetectable		 3h5gA-2xioA:
7.64
3h5gB-2xioA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 4 PHE A  47
LYS A  46
ILE A  36
THR A 221
 None
 1.28A 3ia4B-2xioA:
undetectable		 3ia4B-2xioA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		3 / 3 ASN A  53
ASN A  87
GLU A  95
 None
 0.71A 3kpdC-2xioA:
undetectable		 3kpdC-2xioA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		3 / 3 ASN A  53
ASN A  87
GLU A  95
 None
 0.72A 3kpdB-2xioA:
undetectable		 3kpdB-2xioA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 SER A 153
ASP A 177
ASP A 116
ASP A 118
 None
 1.21A 3n2oC-2xioA:
7.5
3n2oD-2xioA:
5.2		 3n2oC-2xioA:
20.00
3n2oD-2xioA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 6 GLY A  75
ARG A 167
ILE A 110
LEU A  99
 None
 0.85A 4ac9C-2xioA:
3.2		 4ac9C-2xioA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 6 GLY A  75
ARG A 167
ILE A 110
LEU A  99
 None
 0.83A 4acaC-2xioA:
2.9		 4acaC-2xioA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 6 GLY A  75
ARG A 167
ILE A 110
LEU A  99
 None
 0.83A 4acbC-2xioA:
3.2		 4acbC-2xioA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 10 ASP A  34
VAL A  35
GLY A  20
ILE A  21
PRO A 224
 None
 1.08A 4dqcA-2xioA:
undetectable		 4dqcA-2xioA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.99A 4kttA-2xioA:
undetectable		 4kttA-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.96A 4kttC-2xioA:
undetectable		 4kttC-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.97A 4ndnA-2xioA:
undetectable		 4ndnA-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 7 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.91A 4ndnC-2xioA:
undetectable		 4ndnC-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 11 ASP A  34
VAL A  35
GLY A  20
ILE A  21
PRO A 224
 None
 1.01A 4njvB-2xioA:
undetectable		 4njvB-2xioA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 7 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.92A 4odjA-2xioA:
undetectable		 4odjA-2xioA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 6 CYH A  81
GLU A 112
GLY A 111
GLY A  75
 None
EDO  A1299 (-3.9A)
None
None
 0.97A 5a06D-2xioA:
2.6		 5a06D-2xioA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.96A 5a1iA-2xioA:
undetectable		 5a1iA-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 7 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.96A 5a1iA-2xioA:
undetectable		 5a1iA-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		6 / 12 ASP A   8
GLY A  10
ASP A 222
ILE A 266
GLY A 194
ILE A 263
 None
None
EDO  A1299 (-2.9A)
None
None
None
 1.14A 5e5kA-2xioA:
undetectable		 5e5kA-2xioA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 12 GLY A  82
ASN A  88
LEU A  93
GLU A  95
LEU A  96
 None
 1.23A 5nwwA-2xioA:
undetectable		 5nwwA-2xioA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 5 THR A 289
GLU A 220
THR A 221
HIS A 262
 None
 1.35A 5utuH-2xioA:
undetectable		 5utuH-2xioA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		5 / 12 GLY A  82
GLN A 135
VAL A  74
CYH A  76
ASP A  56
 None
 1.36A 6bxnB-2xioA:
undetectable		 6bxnB-2xioA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 LEU A 209
LEU A 206
LEU A 267
ARG A 239
 None
 0.93A 6ce2A-2xioA:
undetectable		 6ce2A-2xioA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.91A 6fbnB-2xioA:
undetectable		 6fbnB-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.98A 6fboA-2xioA:
undetectable		 6fboA-2xioA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 8 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 1.00A 6fcdA-2xioA:
undetectable		 6fcdA-2xioA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens) 		4 / 7 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.97A 6g6rA-2xioA:
undetectable		 6g6rA-2xioA:
21.38