SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xiv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 THR A 463
SER A 414
TRP A 267
GLN A 431
 None
 1.41A 1eiiA-2xivA:
undetectable		 1eiiA-2xivA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 SER A 352
GLY A 350
LEU A 386
TYR A 389
 None
 0.92A 1fduD-2xivA:
undetectable		 1fduD-2xivA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 387
ILE A 423
ARG A 340
LEU A 398
 None
 0.67A 1iepB-2xivA:
undetectable		 1iepB-2xivA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 THR A 378
GLY A 380
GLY A 362
GLY A 361
GLY A 449
 None
 0.91A 1n2xB-2xivA:
undetectable		 1n2xB-2xivA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 THR A 434
VAL A 457
VAL A 466
ASP A 421
 None
 1.01A 1p7rA-2xivA:
undetectable		 1p7rA-2xivA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 SER A 384
VAL A 433
VAL A 387
LEU A 398
 None
 0.76A 3o14A-2xivA:
undetectable		 3o14A-2xivA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 447
ASP A 268
ARG A 458
GLU A 444
 None
 1.26A 4eysA-2xivA:
undetectable		 4eysA-2xivA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 380
GLY A 362
GLY A 363
THR A 296
GLY A 371
 None
 0.80A 4o33A-2xivA:
undetectable		 4o33A-2xivA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 380
GLY A 362
GLY A 363
THR A 296
GLY A 371
 None
 0.77A 4o3fA-2xivA:
undetectable		 4o3fA-2xivA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 444
ARG A 453
GLN A 431
 None
 0.79A 4rtbA-2xivA:
undetectable		 4rtbA-2xivA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 286
ALA A 295
GLN A 299
VAL A 300
 None
 0.91A 5i8fA-2xivA:
undetectable		 5i8fA-2xivA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 467
TYR A 406
GLN A 405
 None
 0.73A 5qgrA-2xivA:
undetectable		 5qgrA-2xivA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2xiv HYPOTHETICAL
INVASION PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 467
TYR A 406
GLN A 405
 None
 0.75A 5qgtA-2xivA:
undetectable		 5qgtA-2xivA:
21.49