SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		4 / 8 HIS A 163
GLY A 166
LEU A 205
ASP A 208
 HEM  A1001 (-3.2A)
HEM  A1001 (-3.2A)
HEM  A1001 ( 4.9A)
None
 0.40A 1aegA-2xj6A:
34.5		 1aegA-2xj6A:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		5 / 6 CYH A  32
PRO A  34
LEU A  35
HIS A 169
ARG A 172
 None
HEM  A1001 (-4.3A)
HEM  A1001 ( 4.3A)
HEM  A1001 (-3.9A)
HEM  A1001 (-4.6A)
 0.12A 1oafA-2xj6A:
46.4		 1oafA-2xj6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		3 / 3 ASP A 155
LEU A 159
HIS A 116
 None
HEM  A1001 (-4.0A)
None
 0.74A 1qknA-2xj6A:
undetectable		 1qknA-2xj6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		3 / 3 TYR A  97
GLY A  58
ASP A 121
 None
 0.71A 3ou6C-2xj6A:
undetectable		 3ou6C-2xj6A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		5 / 12 GLY A 162
SER A 160
LEU A  37
ALA A  44
HIS A  42
 HEM  A1001 ( 3.9A)
HEM  A1001 ( 3.8A)
HEM  A1001 ( 4.3A)
None
None
 1.28A 3ou7C-2xj6A:
undetectable		 3ou7C-2xj6A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		4 / 7 PRO A 127
GLY A 129
ALA A 148
ASP A  48
 SO4  A1002 (-4.1A)
None
None
None
 0.76A 3ur0B-2xj6A:
undetectable		 3ur0B-2xj6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		5 / 12 TYR A 235
GLY A 161
TYR A 224
ALA A 167
PHE A 186
 None
None
None
HEM  A1001 (-4.6A)
None
 1.12A 3vywD-2xj6A:
undetectable		 3vywD-2xj6A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		4 / 5 TYR A   5
GLN A 240
SER A 243
ASP A  95
 None
 1.35A 4qtuB-2xj6A:
undetectable		 4qtuB-2xj6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		4 / 5 ARG A  38
TRP A  41
HIS A  42
ALA A  70
 HEM  A1001 ( 4.2A)
HEM  A1001 (-3.5A)
None
None
 0.42A 5syiA-2xj6A:
10.2		 5syiA-2xj6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB806_1
(CATALASE-PEROXIDASE)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		4 / 5 ARG A  38
TRP A  41
HIS A  42
SER A 173
 HEM  A1001 ( 4.2A)
HEM  A1001 (-3.5A)
None
HEM  A1001 (-2.7A)
 0.36A 5syiB-2xj6A:
28.0		 5syiB-2xj6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		4 / 6 ARG A  38
TRP A  41
HIS A  42
SER A 173
 HEM  A1001 ( 4.2A)
HEM  A1001 (-3.5A)
None
HEM  A1001 (-2.7A)
 0.36A 5syjA-2xj6A:
11.4		 5syjA-2xj6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		4 / 6 ARG A  38
TRP A  41
HIS A  42
SER A 173
 HEM  A1001 ( 4.2A)
HEM  A1001 (-3.5A)
None
HEM  A1001 (-2.7A)
 0.38A 5syjB-2xj6A:
11.5		 5syjB-2xj6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2xj6 ASCORBATE PEROXIDASE
(Glycine
max) 		5 / 12 LEU A  23
VAL A 103
GLY A 101
PHE A 247
PHE A 115
 None
 1.41A 6a94A-2xj6A:
undetectable		 6a94A-2xj6A:
20.87