SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xj9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 9 PHE A  97
ILE A 109
ASP A  78
LEU A  74
PHE A  93
 None
 1.47A 1i00B-2xj9A:
undetectable		 1i00B-2xj9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 11 PHE A  97
ILE A 109
ASP A  78
PHE A  93
ALA A  49
 None
 1.11A 1ju6A-2xj9A:
undetectable		 1ju6A-2xj9A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 GLY A 144
SER A 160
VAL A 183
SER A 136
LEU A 203
 None
 1.30A 1ya4B-2xj9A:
2.8		 1ya4B-2xj9A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 5 ARG A  55
PHE A  52
THR A  27
LEU A  29
 None
 1.23A 2e1qD-2xj9A:
undetectable		 2e1qD-2xj9A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 210
PHE A 212
VAL A 183
LEU A 143
THR A 131
 None
 1.22A 2jn3A-2xj9A:
undetectable		 2jn3A-2xj9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 4 SER A 157
GLY A 144
HIS A 123
ASP A 110
 None
 1.33A 2oxtC-2xj9A:
2.4		 2oxtC-2xj9A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 6 ARG A 225
ILE A  21
LEU A 184
GLU A 256
 AGS  A1272 (-3.6A)
None
None
None
 1.07A 2ya7A-2xj9A:
undetectable		 2ya7A-2xj9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 6 ARG A 225
ILE A  21
LEU A 184
GLU A 256
 AGS  A1272 (-3.6A)
None
None
None
 1.07A 2ya7B-2xj9A:
undetectable		 2ya7B-2xj9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 6 ARG A 225
ILE A  21
LEU A 184
GLU A 256
 AGS  A1272 (-3.6A)
None
None
None
 1.04A 2ya7D-2xj9A:
undetectable		 2ya7D-2xj9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.98A 3pghA-2xj9A:
undetectable		 3pghA-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.99A 3pghC-2xj9A:
undetectable		 3pghC-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 10 ILE A 234
ALA A 235
THR A  27
VAL A  23
THR A  20
 None
None
None
None
AGS  A1272 (-3.7A)
 1.31A 3r9cA-2xj9A:
undetectable		 3r9cA-2xj9A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.93A 3rr3A-2xj9A:
undetectable		 3rr3A-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.92A 3rr3B-2xj9A:
undetectable		 3rr3B-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.93A 3rr3C-2xj9A:
undetectable		 3rr3C-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.93A 3rr3D-2xj9A:
undetectable		 3rr3D-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 9 PHE A  97
ILE A 109
ASP A  78
LEU A  74
PHE A  93
 None
 1.49A 4eb4C-2xj9A:
undetectable		 4eb4C-2xj9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 7 ARG A 219
GLY A 217
ALA A 253
GLU A 256
 None
 0.88A 4g0uB-2xj9A:
undetectable		 4g0uB-2xj9A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 6 ARG A 219
GLY A 217
ALA A 253
GLU A 256
 None
 0.95A 4g0uA-2xj9A:
undetectable		 4g0uA-2xj9A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 4 ASP A 236
LEU A  66
ARG A  56
THR A 233
 None
 1.20A 4kjjA-2xj9A:
5.0		 4kjjA-2xj9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 4 ASP A 236
LEU A  66
ARG A  56
THR A 233
 None
 1.26A 4kjkA-2xj9A:
5.0		 4kjkA-2xj9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 5 GLY A  10
LEU A 108
ILE A  21
LEU A 264
 None
 0.84A 4o8fA-2xj9A:
undetectable		 4o8fA-2xj9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 10 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 1.09A 4ph9A-2xj9A:
undetectable		 4ph9A-2xj9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 10 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 1.09A 4ph9B-2xj9A:
undetectable		 4ph9B-2xj9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 5 SER A 136
ARG A 219
GLY A 217
GLU A 256
 None
 1.13A 5btiA-2xj9A:
undetectable
5btiB-2xj9A:
2.7		 5btiA-2xj9A:
21.65
5btiB-2xj9A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 12 ASP A 236
PRO A  69
GLU A  53
PHE A  52
ARG A  56
 None
 1.27A 5il1A-2xj9A:
undetectable		 5il1A-2xj9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		3 / 3 PRO A  85
ARG A  84
GLU A  87
 None
 0.73A 5j6hA-2xj9A:
undetectable		 5j6hA-2xj9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		4 / 5 THR A  27
HIS A  24
ALA A 235
ASP A 236
 None
 1.30A 5mfxA-2xj9A:
3.0		 5mfxA-2xj9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		5 / 10 VAL A   8
ILE A 109
LEU A  41
ARG A 125
GLY A 124
 None
 1.16A 5mxbA-2xj9A:
undetectable		 5mxbA-2xj9A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		3 / 3 LEU A 158
LEU A 161
TRP A 164
 None
 0.85A 5nwuA-2xj9A:
undetectable		 5nwuA-2xj9A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2xj9 MIPZ
(Caulobacter
vibrioides) 		3 / 3 GLY A 231
ASP A 236
ILE A  64
 None
 0.62A 6dgxB-2xj9A:
undetectable		 6dgxB-2xj9A:
13.52