SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xjy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 2xjy LIM DOMAIN-BINDING
PROTEIN 1
RHOMBOTIN-2
(Homo
sapiens) 		4 / 8 GLY B 348
GLY B 347
ILE A 101
THR A 107
 None
 0.49A 3d41A-2xjyB:
undetectable		 3d41A-2xjyB:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2xjy RHOMBOTIN-2
LIM DOMAIN-BINDING
PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		4 / 5 VAL A 110
VAL B 340
GLY B 341
PHE A 120
 None
 0.75A 5d4nA-2xjyA:
undetectable
5d4nC-2xjyA:
undetectable		 5d4nA-2xjyA:
21.32
5d4nC-2xjyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2xjy RHOMBOTIN-2
LIM DOMAIN-BINDING
PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY A  89
LEU A  85
GLY B 351
ASP B 354
GLN A  90
 None
 1.07A 5hg0A-2xjyA:
undetectable		 5hg0A-2xjyA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 2xjy RHOMBOTIN-2
LIM DOMAIN-BINDING
PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY A  89
LEU A  85
GLY B 351
ASP B 354
GLN A  90
 None
 1.09A 5hg0B-2xjyA:
undetectable		 5hg0B-2xjyA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xjy RHOMBOTIN-2
(Homo
sapiens) 		4 / 5 ARG A 109
MET A 108
THR A 107
LEU A 117
 None
 1.36A 5x1bW-2xjyA:
undetectable		 5x1bW-2xjyA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xjy RHOMBOTIN-2
(Homo
sapiens) 		4 / 5 ARG A 109
MET A 108
THR A 107
LEU A 117
 None
 1.37A 6nknJ-2xjyA:
undetectable		 6nknJ-2xjyA:
15.62