SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A  56
PHE A  79
LEU A 115
LEU A 148
LEU A 135
 None
 1.22A 1og5A-2xkaA:
undetectable		 1og5A-2xkaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 PHE A 280
LEU A 281
PHE A 315
PRO A 382
LEU A 183
 None
 1.13A 1og5B-2xkaA:
undetectable		 1og5B-2xkaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 ASP A  97
THR A  93
GLU A 185
 None
 0.56A 1pj7A-2xkaA:
3.3		 1pj7A-2xkaA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 304
ILE A 283
THR A 247
ILE A 343
LEU A 347
 None
 1.19A 1tw4B-2xkaA:
undetectable		 1tw4B-2xkaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A 284
PHE A 308
ASP A 305
TYR A 350
ARG A 302
 None
 1.50A 2avdA-2xkaA:
undetectable		 2avdA-2xkaA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 274
LEU A 270
ILE A  23
ILE A  21
THR A 247
 None
 0.91A 2bdmA-2xkaA:
undetectable		 2bdmA-2xkaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 GLY A 361
TYR A 321
ASP A 362
ASP A 332
 None
 1.01A 2g72B-2xkaA:
2.5		 2g72B-2xkaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 LEU A 132
PRO A 382
VAL A 208
MET A 379
 None
 1.36A 2hrcA-2xkaA:
undetectable		 2hrcA-2xkaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 ILE A 209
LEU A 248
ASN A 252
ASN A 207
ILE A  23
 None
 1.23A 2nnhB-2xkaA:
undetectable		 2nnhB-2xkaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 ILE A 209
LEU A 248
ASN A 252
VAL A  27
ILE A  23
 None
 1.26A 2nnhB-2xkaA:
undetectable		 2nnhB-2xkaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 PHE A 308
ALA A 311
ILE A 219
ILE A 220
THR A 214
 None
 1.16A 2rlcA-2xkaA:
undetectable		 2rlcA-2xkaA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 132
ILE A 153
LEU A 205
VAL A 208
ILE A 166
 None
 1.03A 3adxB-2xkaA:
undetectable		 3adxB-2xkaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 VAL A  18
HIS A 249
LEU A   8
TRP A 365
 None
 1.22A 3arrA-2xkaA:
undetectable		 3arrA-2xkaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 165
VAL A  27
GLY A  26
ILE A  21
LEU A 248
 None
 1.10A 3ijdA-2xkaA:
2.1		 3ijdA-2xkaA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 PRO A  89
GLY A 140
GLY A 139
ASP A  94
LEU A 152
 None
GSP  A 900 (-3.3A)
GSP  A 900 (-3.3A)
None
None
 1.02A 3m6vA-2xkaA:
2.7		 3m6vA-2xkaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 PRO A  89
GLY A 140
GLY A 139
ASP A  94
LEU A 152
 None
GSP  A 900 (-3.3A)
GSP  A 900 (-3.3A)
None
None
 1.02A 3m6vB-2xkaA:
3.0		 3m6vB-2xkaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 PRO A  89
GLY A 140
GLY A 139
ASP A  94
LEU A 152
 None
GSP  A 900 (-3.3A)
GSP  A 900 (-3.3A)
None
None
 1.01A 3m6wA-2xkaA:
undetectable		 3m6wA-2xkaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 VAL A 371
ASN A 367
TYR A 373
GLU A 250
 None
 1.21A 3q5sA-2xkaA:
0.0		 3q5sA-2xkaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 LEU A 293
LEU A 296
GLU A 297
ILE A 343
 None
 0.84A 4ww7A-2xkaA:
undetectable		 4ww7A-2xkaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		4 / 8 GLY A 307
LYS A 285
ALA A 286
PHE A 308
 None
 0.83A 5mvsB-2xkaA:
undetectable		 5mvsB-2xkaA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 PHE A 119
ARG A 117
ILE A  77
LEU A 148
ILE A  28
 None
 1.23A 5y2tB-2xkaA:
undetectable		 5y2tB-2xkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 LYS A 335
ASN A 262
SER A 260
 None
 1.29A 5yw0A-2xkaA:
undetectable		 5yw0A-2xkaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 VAL A 208
PHE A 189
ILE A 186
TRP A 145
VAL A 149
 None
 1.43A 6gsdA-2xkaA:
6.0		 6gsdA-2xkaA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2xka FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 THR A  14
GLU A 250
ASN A 367
 None
 0.91A 6nj9K-2xkaA:
undetectable		 6nj9K-2xkaA:
22.22