SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2xko GLOBAL NITROGEN
REGULATOR
(Synechococcus
elongatus) 		5 / 12 VAL A 189
VAL A 211
LEU A 148
LEU A 152
LEU A 217
 None
 1.31A 1mx1E-2xkoA:
undetectable		 1mx1E-2xkoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2xko GLOBAL NITROGEN
REGULATOR
(Synechococcus
elongatus) 		5 / 12 LEU A 148
LEU A 155
CYH A 156
ILE A 209
ILE A 178
 None
 0.76A 4a79A-2xkoA:
undetectable		 4a79A-2xkoA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2xko GLOBAL NITROGEN
REGULATOR
(Synechococcus
elongatus) 		5 / 12 LEU A 148
LEU A 155
CYH A 156
ILE A 209
ILE A 178
 None
 0.75A 4a79B-2xkoA:
undetectable		 4a79B-2xkoA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2xko GLOBAL NITROGEN
REGULATOR
(Synechococcus
elongatus) 		5 / 11 LEU A 148
LEU A 155
CYH A 156
ILE A 209
ILE A 178
 None
 0.80A 4a7aA-2xkoA:
undetectable		 4a7aA-2xkoA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2xko GLOBAL NITROGEN
REGULATOR
(Synechococcus
elongatus) 		5 / 12 LEU A 148
LEU A 155
CYH A 156
ILE A 209
ILE A 178
 None
 0.79A 4a7aB-2xkoA:
undetectable		 4a7aB-2xkoA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2xko PIPX
(Synechococcus
elongatus) 		4 / 7 ALA C  57
PHE C  88
ALA C  29
LEU C  27
 None
 0.79A 4du2B-2xkoC:
undetectable		 4du2B-2xkoC:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2xko GLOBAL NITROGEN
REGULATOR
(Synechococcus
elongatus) 		3 / 3 ARG A 114
LEU A 117
GLU A 116
 None
 0.69A 4l3gF-2xkoA:
undetectable		 4l3gF-2xkoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2xko GLOBAL NITROGEN
REGULATOR
(Synechococcus
elongatus) 		4 / 7 VAL A  51
LEU A  53
SER A  54
GLU A  62
 None
AKG  A1223 (-4.2A)
None
None
 1.10A 4zphA-2xkoA:
undetectable
4zphB-2xkoA:
undetectable		 4zphA-2xkoA:
20.51
4zphB-2xkoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2xko GLOBAL NITROGEN
REGULATOR
PIPX
(Synechococcus
elongatus) 		3 / 3 ARG C  35
PHE C  49
LEU A  80
 None
 0.76A 5veuA-2xkoC:
undetectable		 5veuA-2xkoC:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xko GLOBAL NITROGEN
REGULATOR
(Synechococcus
elongatus) 		3 / 3 ARG A 128
LEU A  68
PHE A  94
 AKG  A1223 (-2.7A)
None
None
 0.79A 6nknP-2xkoA:
undetectable		 6nknP-2xkoA:
22.42