SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2xl4 LMO0438 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 118
LEU A  64
ALA A  65
LYS A  68
LEU A 191
 None
 0.83A 3dauA-2xl4A:
undetectable		 3dauA-2xl4A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 2xl4 LMO0438 PROTEIN
(Listeria
monocytogenes) 		4 / 4 PHE A 137
LYS A 138
ILE A  67
THR A 189
 None
 1.32A 3ia4B-2xl4A:
undetectable		 3ia4B-2xl4A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2xl4 LMO0438 PROTEIN
(Listeria
monocytogenes) 		4 / 5 ASP A 202
THR A 184
LEU A 200
GLU A  75
 None
 1.43A 4a3pA-2xl4A:
undetectable		 4a3pA-2xl4A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2xl4 LMO0438 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 118
LEU A  64
ALA A  65
LYS A  68
LEU A 191
 None
 0.81A 4psyA-2xl4A:
undetectable		 4psyA-2xl4A:
18.08