SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 ASP A 202
GLY A 208
SER A  95
SER A  93
THR A 295
 None
 1.22A 1m4gB-2xlaA:
undetectable		 1m4gB-2xlaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 ASP A 202
GLY A 208
SER A  95
THR A 295
 None
 0.78A 1m4iA-2xlaA:
undetectable		 1m4iA-2xlaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 4 HIS A 178
GLU A 124
HIS A 119
HIS A 117
 CU  A1298 (-3.4A)
CU  A1298 (-2.6A)
CU  A1298 (-3.2A)
CU  A1298 (-3.3A)
 1.17A 1os2D-2xlaA:
undetectable		 1os2D-2xlaA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 ILE A  91
TYR A 213
PHE A  89
THR A  83
GLU A  87
 None
None
None
URE  A1299 ( 4.8A)
URE  A1299 (-2.6A)
 1.46A 2dttE-2xlaA:
0.0
2dttF-2xlaA:
0.0		 2dttE-2xlaA:
20.17
2dttF-2xlaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 4 HIS A 178
GLU A 124
HIS A 119
HIS A 117
 CU  A1298 (-3.4A)
CU  A1298 (-2.6A)
CU  A1298 (-3.2A)
CU  A1298 (-3.3A)
 1.18A 2hu6A-2xlaA:
undetectable		 2hu6A-2xlaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 4 HIS A 178
GLU A 124
HIS A 119
HIS A 117
 CU  A1298 (-3.4A)
CU  A1298 (-2.6A)
CU  A1298 (-3.2A)
CU  A1298 (-3.3A)
 1.14A 2ozrC-2xlaA:
undetectable		 2ozrC-2xlaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 4 HIS A 178
GLU A 124
HIS A 119
HIS A 117
 CU  A1298 (-3.4A)
CU  A1298 (-2.6A)
CU  A1298 (-3.2A)
CU  A1298 (-3.3A)
 1.13A 2ozrD-2xlaA:
undetectable		 2ozrD-2xlaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLU A 124
GLN A 249
PHE A 238
ILE A 247
 CU  A1298 (-2.6A)
None
URE  A1299 (-4.7A)
None
 1.03A 2qmzA-2xlaA:
undetectable
2qmzB-2xlaA:
undetectable		 2qmzA-2xlaA:
21.21
2qmzB-2xlaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 MET A 195
TRP A 125
GLY A 100
ILE A  99
 None
 0.87A 2zm9A-2xlaA:
undetectable		 2zm9A-2xlaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A 211
ALA A 102
ILE A 103
PRO A  73
 None
 0.88A 3fxrA-2xlaA:
undetectable		 3fxrA-2xlaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  81
ILE A 133
LEU A 135
GLY A 112
ILE A 108
 None
 1.20A 4o1eA-2xlaA:
undetectable		 4o1eA-2xlaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  81
ILE A 133
LEU A 135
GLY A 113
ILE A 108
 None
 1.19A 4o1eA-2xlaA:
undetectable		 4o1eA-2xlaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  91
ILE A 133
LEU A 135
GLY A 113
ILE A 108
 None
 1.12A 4o1eA-2xlaA:
undetectable		 4o1eA-2xlaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  81
ILE A 133
LEU A 135
GLY A 113
ILE A 108
 None
 1.18A 4o1eB-2xlaA:
undetectable		 4o1eB-2xlaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 PRO A 189
GLY A 131
PRO A 166
TRP A 127
 None
 1.15A 5kf8A-2xlaA:
undetectable		 5kf8A-2xlaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 PRO A 189
GLY A 131
PRO A 166
TRP A 127
 None
 1.11A 5kgpA-2xlaA:
undetectable		 5kgpA-2xlaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 4 HIS A 178
GLU A 124
HIS A 119
HIS A 117
 CU  A1298 (-3.4A)
CU  A1298 (-2.6A)
CU  A1298 (-3.2A)
CU  A1298 (-3.3A)
 1.19A 5n5jA-2xlaA:
undetectable		 5n5jA-2xlaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 HIS A 117
HIS A 178
HIS A 119
 CU  A1298 (-3.3A)
CU  A1298 (-3.4A)
CU  A1298 (-3.2A)
 0.40A 5zrdA-2xlaA:
undetectable		 5zrdA-2xlaA:
18.53