SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xlr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 5 ARG A 115
LYS A 118
ALA A 119
ASP A  88
 None
 1.07A 1e7bA-2xlrA:
undetectable		 1e7bA-2xlrA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 8 SER A 231
ILE A 273
LEU A 206
ASP A 193
 None
 0.71A 1jg4A-2xlrA:
undetectable		 1jg4A-2xlrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 9 LEU A 286
HIS A 281
LEU A 292
HIS A 169
GLY A 319
 None
None
None
None
FAD  A 500 ( 4.7A)
 1.35A 1mjlA-2xlrA:
undetectable
1mjlB-2xlrA:
undetectable		 1mjlA-2xlrA:
13.11
1mjlB-2xlrA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 LEU A 286
HIS A 281
LEU A 292
HIS A 169
GLY A 319
 None
None
None
None
FAD  A 500 ( 4.7A)
 1.36A 1mjqI-2xlrA:
undetectable
1mjqJ-2xlrA:
undetectable		 1mjqI-2xlrA:
13.11
1mjqJ-2xlrA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 5 LEU A 206
LEU A 229
CYH A 276
THR A 277
 None
None
None
NAP  A 501 (-4.3A)
 1.27A 2oaxD-2xlrA:
undetectable		 2oaxD-2xlrA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 8 ARG A 105
TRP A  52
HIS A  68
GLN A  45
 None
FAD  A 500 (-4.2A)
FAD  A 500 (-3.4A)
FAD  A 500 (-4.2A)
 1.49A 2vxaA-2xlrA:
undetectable
2vxaB-2xlrA:
undetectable
2vxaK-2xlrA:
undetectable		 2vxaA-2xlrA:
8.99
2vxaB-2xlrA:
8.99
2vxaK-2xlrA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 VAL A 121
GLY A  19
TYR A 124
GLN A 323
TRP A  52
 None
None
None
FAD  A 500 ( 3.2A)
FAD  A 500 (-4.2A)
 1.17A 2zthA-2xlrA:
3.0		 2zthA-2xlrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 ARG A 122
ILE A 112
TRP A 109
 None
 1.20A 3e6tB-2xlrA:
undetectable		 3e6tB-2xlrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLY A  49
GLY A  16
VAL A 107
ASP A 110
PRO A 103
 None
FAD  A 500 (-3.5A)
None
None
None
 1.04A 3m6vA-2xlrA:
2.4		 3m6vA-2xlrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLY A  49
GLY A  16
VAL A 107
ASP A 110
PRO A 103
 None
FAD  A 500 (-3.5A)
None
None
None
 1.06A 3m6vB-2xlrA:
undetectable		 3m6vB-2xlrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLY A  49
GLY A  16
VAL A 107
ASP A 110
PRO A 103
 None
FAD  A 500 (-3.5A)
None
None
None
 1.04A 3m6wA-2xlrA:
undetectable		 3m6wA-2xlrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 8 GLU A  82
SER A  77
ALA A 430
ALA A 100
 None
FAD  A 500 (-4.4A)
None
None
 0.99A 3ns1L-2xlrA:
undetectable		 3ns1L-2xlrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 ARG A 122
ILE A 112
TRP A 109
 None
 1.14A 3nw2A-2xlrA:
undetectable		 3nw2A-2xlrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 LEU A 229
TYR A 240
ALA A 214
GLY A 218
SER A 219
 None
 1.19A 3ou6D-2xlrA:
undetectable		 3ou6D-2xlrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 LEU A 229
TYR A 240
ALA A 214
GLY A 218
SER A 219
 None
 1.23A 3ou7A-2xlrA:
2.2		 3ou7A-2xlrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 LEU A 229
TYR A 240
ALA A 214
GLY A 218
SER A 219
 None
 1.22A 3ou7D-2xlrA:
undetectable		 3ou7D-2xlrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLN A 323
HIS A 169
PRO A  17
ALA A  15
GLY A  14
 FAD  A 500 ( 3.2A)
None
FAD  A 500 (-3.7A)
None
FAD  A 500 (-3.5A)
 1.22A 3v3oB-2xlrA:
10.1		 3v3oB-2xlrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 8 VAL A 164
TYR A 162
LEU A 347
TYR A 336
 None
 1.00A 3v81A-2xlrA:
undetectable		 3v81A-2xlrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 7 SER A  70
TRP A  52
HIS A  68
SER A 171
 FAD  A 500 ( 4.3A)
FAD  A 500 (-4.2A)
FAD  A 500 (-3.4A)
None
 1.25A 4k7gB-2xlrA:
undetectable		 4k7gB-2xlrA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA304_1
(CHITOSANASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 4 TYR A 325
ILE A 395
THR A 398
TYR A 390
 None
 1.37A 4oltA-2xlrA:
0.0		 4oltA-2xlrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 5 TYR A 325
ILE A 395
THR A 398
TYR A 390
 None
 1.39A 4oltB-2xlrA:
0.0		 4oltB-2xlrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLY A 319
GLN A 321
MET A 329
LEU A 384
ILE A  12
 FAD  A 500 ( 4.7A)
None
None
None
None
 1.25A 4p6xE-2xlrA:
undetectable		 4p6xE-2xlrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 8 VAL A 164
TYR A 162
LEU A 347
TYR A 336
 None
 0.94A 4puoC-2xlrA:
undetectable		 4puoC-2xlrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 6 TYR A 325
ILE A 395
THR A 398
TYR A 390
 None
 1.38A 4qwpA-2xlrA:
undetectable		 4qwpA-2xlrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 5 TYR A 325
ILE A 395
THR A 398
TYR A 390
 None
 1.33A 4qwpB-2xlrA:
undetectable		 4qwpB-2xlrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 PRO A 348
VAL A 308
ALA A 334
ALA A 337
VAL A 340
 None
 1.47A 5igpA-2xlrA:
undetectable		 5igpA-2xlrA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 6 LEU A 301
TYR A 376
THR A 366
LEU A 365
 None
 1.01A 5x1fA-2xlrA:
undetectable
5x1fJ-2xlrA:
undetectable		 5x1fA-2xlrA:
21.20
5x1fJ-2xlrA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2xlr FLAVIN-CONTAINING
MONOOXYGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 LEU A  75
ASP A 193
ILE A 274
 None
 0.62A 6dh0B-2xlrA:
undetectable		 6dh0B-2xlrA:
11.17